Coexposed nanoparticulate Ag alleviates the acute toxicity induced by ionic Ag+ in vivo

Lai, Yujian; Dong, Lijie; Zhou, Hongyu; Yan, Bing; Chen, Yongsheng; Cai, Yunqi; Liu, Jingfu

doi:10.1016/j.scitotenv.2020.138050

Cited by 34 publications

(18 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The reported results display the hepato-and genotoxic properties of AgNPs [27]. A single intravenous exposure of rats to 20.1 ± 2.8 nm AgNPs (5 mg/kg) produced no toxic effects on the liver cells despite considerable AgNPs accumulation in the liver (60% of the introduced NPs within the first 24 h) according to the histopathological and biochemical studies [25]. Park et al [28] studied the effects of the exposure of mice 42 nm AgNPs at a dose of 0.25 mg/kg, 0.5 mg/kg and 1 mg/kg for 28 days.…”

Section: Introductionmentioning

confidence: 66%

See 1 more Smart Citation

In Vivo Study of Entero- and Hepatotoxicity of Silver Nanoparticles Stabilized with Benzyldimethyl-[3-myristoylamine)-propyl]ammonium Chloride (Miramistin) to CBF1 Mice upon Enteral Administration

et al. 2021

View full text Add to dashboard Cite

Silver nanoparticles (AgNPs) are the most widely studied antimicrobial nanomaterials. However, their use in biomedicine is currently limited due to the availability of data that prove the nanosilver toxicity associated primarily with oxidative stress development in mammalian cells. The surface modification of AgNPs is a potent technique of improvement of their biocompatibility. The synthetic or natural compounds that combine zero or low toxicity towards human and animal organisms with inherent antimicrobial properties are the most promising stabilizing agents, their use would also minimize the risks of microorganisms developing resistance to silver-based materials. We used a simple technique to obtain 30–60 nm AgNPs stabilized with benzyldimethyl[3-myristoylamine)-propyl]ammonium chloride monohydrate (BAC)—a well-known active ingredient of many antibacterial drugs. The objective of the study was to assess the AgNPs-BAC entero- and hepatotoxicity to CBF1 mice upon enteral administration. The animals were exposed to 0.8–7.5 mg/kg doses of AgNPs-BAC in the acute and to 0.05–2.25 mg/kg doses of AgNPs-BAC in the subacute experiments. No significant entero- and hepatotoxic effects following a single exposure to doses smaller than 4 mg/kg were detected. Repeated exposure to the doses of AgNPs-BAC below 0.45 mg/kg and to the doses of BAC below 0.5 mg/kg upon enteral administration also led to no adverse effects. During the acute experiment, the higher AgNPs-BAC dose resulted in increased quantities of aminotransferases and urea, as well as the albumin-globulin ratio shift, which are indicative of inflammatory processes. Besides, the relative mass of the liver of mice was smaller compared to the control. During the subacute experiment, the groups treated with the 0.25–2.25 mg/kg dose of AgNPs-BAC had a lower weight gain rate compared to the control, while the groups treated with the 2.25 mg/kg dose of AgNPs-BAC showed statistically significant variations in the blood serum transaminases activity, which indicated hepatosis. It should be noted that the spleen and liver of the animals from the groups treated with the 0.45 and 2.25 mg/kg dose of AgNPs-BAC were more than two times smaller compared to the control. In the intestines of some animals from the group treated with the 2.25 mg/kg dose of AgNPs-BAC small areas of hyperemia and enlarged Peyer’s patches were observed. Histological examination confirmed the initial stages of the liver and intestinal wall inflammation.

show abstract

Section: Introductionmentioning

confidence: 66%

“…After entering blood vessels, AgNPs are mostly accumulated in the liver [25,26], often leading to pathological changes in its tissues and cells. In order to study the pathological potential of 8.7 nm AgNPs, the NPs were administered abdominally to female rats for 28 days at a dose of 1 mg/kg, 2 mg/kg and 4 mg/kg.…”

Section: Introductionmentioning

confidence: 99%

In Vivo Study of Entero- and Hepatotoxicity of Silver Nanoparticles Stabilized with Benzyldimethyl-[3-myristoylamine)-propyl]ammonium Chloride (Miramistin) to CBF1 Mice upon Enteral Administration

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Silver NPs have a good killing effect on Gram-positive cocci represented by Staphylococcus aureus and Gram-negative bacilli represented by Escherichia coli ( Deshmukh et al, 2018 ; Subramaniyan et al, 2019 ). Currently, the biggest challenge is to enable the stable release of silver at a suitable concentration on the surface of metal implants ( Yang Z. et al, 2019 ; Zhu Y. et al, 2019 ; Lai et al, 2020 ). The nanotube structure, which is prepared on the surface of the titanium substrate and loaded with silver or Ag 2 O NPs, is one of the solutions.…”

Section: Nanomaterials Loadingmentioning

confidence: 99%

Nano-Modified Titanium Implant Materials: A Way Toward Improved Antibacterial Properties

Liu

Attarilar

et al. 2020

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

show abstract

“…Still because of their small size, nanoparticles can translocate and reach the systemic circulation to be potentially distributed to other organs. This explains why some studies investigated the damages to the cardio-vascular system (Asweto et al, 2017;Feng et al, 2018Feng et al, , 2017 and to other organs (Cotena et al, 2021;Courter et al, 2007;Deville et al, 2016;Ku et al, 2017;Lai et al, 2020;Roje et al, 2019;Schirinzi et al, 2017;Teng et al, 2020;Xia et al, 2011). Among the different organs, the digestive system is quite well studied (Ahamed et al, 2020a(Ahamed et al, , 2019bCao et al, 2021Cao et al, , 2019Dussert et al, 2020;Shi et al, 2010;Zheng et al, 2012).…”

Section: A Literature Review On the Joint Toxicity Of Nanoparticles And Co-contaminantsmentioning

confidence: 99%

“…In Table 2, the category other/ various includes studies on the nervous system (Ku et al, 2017;Schirinzi et al, 2017), immune system (Deville et al, 2016), kidney cells (Xia et al, 2011), breast cells (Roje et al, 2019), on carcinogenesis (Courter et al, 2007), reproductive organs (Cotena et al, 2021), fetus (Teng et al, 2020) or deal with global effects, affecting several organs (Courter et al, 2007;Lai et al, 2020;Teng et al, 2020).…”

Section: A Literature Review On the Joint Toxicity Of Nanoparticles And Co-contaminantsmentioning

confidence: 99%

Combined effects of nanoparticles and other environmental contaminants on human health - an issue often overlooked

Forest

2021

NanoImpact

View full text Add to dashboard Cite

Air pollution is considered as a major public health issue worldwide. It consists of a complex mixture of pollutants including nanoparticles to which we are increasingly exposed to due to the dramatic development of the nanotechnologies and their incidental or intentional release in the environment. Consequently, some concerns have raised about the combined toxicity of air particulates and other air pollutants on human health. However, the interactions between the contaminants and their resulting combined toxicity are often overlooked. Indeed, the biological effects triggered by nanoparticles are usually assessed focusing on individual nanoparticles, while their interaction with co-contaminants can deeply impact, either positively or negatively, their biodistribution, fate in the organism and toxicological profile (additive, synergistic or antagonistic responses). This paper presents a bibliographic review on the combined toxicity of nanoparticles and co-pollutants and discusses the underlying mechanisms. It also highlights the scarcity of data in the current literature, arguing for an urgent need to take into account the mixture effects to be more representative of real-life conditions for a better and accurate human health risk assessment and management.

show abstract

Coexposed nanoparticulate Ag alleviates the acute toxicity induced by ionic Ag+ in vivo

Cited by 34 publications

References 48 publications

In Vivo Study of Entero- and Hepatotoxicity of Silver Nanoparticles Stabilized with Benzyldimethyl-[3-myristoylamine)-propyl]ammonium Chloride (Miramistin) to CBF1 Mice upon Enteral Administration

In Vivo Study of Entero- and Hepatotoxicity of Silver Nanoparticles Stabilized with Benzyldimethyl-[3-myristoylamine)-propyl]ammonium Chloride (Miramistin) to CBF1 Mice upon Enteral Administration

Nano-Modified Titanium Implant Materials: A Way Toward Improved Antibacterial Properties

Combined effects of nanoparticles and other environmental contaminants on human health - an issue often overlooked

Contact Info

Product

Resources

About