Coffee and tea consumption and the risk of Parkinson's disease

Abstract

Several prospective studies have assessed the association between coffee consumption and Parkinson's disease (PD) risk, but the results are inconsistent. We examined the association of coffee and tea consumption with the risk of incident PD among 29,335 Finnish subjects aged 25 to 74 years without a history of PD at baseline. During a mean follow-up of 12.9 years, 102 men and 98 women developed an incident PD. The multivariate-adjusted (age, body mass index, systolic blood pressure, total cholesterol, education, leisure-time physical activity, smoking, alcohol and tea consumption, and history of diabetes) hazard ratios (HRs) of PD associated with the amount of coffee consumed daily (0, 1-4, and > or = 5 cups) were 1.00, 0.55, and 0.41 (P for trend = 0.063) in men, 1.00, 0.50, and 0.39 (P for trend = 0.073) in women, and 1.00, 0.53, and 0.40 (P for trend = 0.005) in men and women combined (adjusted also for sex), respectively. In both sexes combined, the multivariate-adjusted HRs of PD for subjects drinking > or = 3 cups of tea daily compared with tea nondrinkers was 0.41 (95% CI 0.20-0.83). These results suggest that coffee drinking is associated with a lower risk of PD. More tea drinking is associated with a lower risk of PD.

Epidemiology and etiology of Parkinson’s disease: a review of the evidence

“…The Leisure World cohort study and a Finnish cohort study reported no associations [434,481]. In the Health Professionals Follow-up Study [478], there was an inverse association between tea intake and PD in men who did not drink coffee (RR 0.4, 95% CI 0.2-1.2 for more than one cup per day versus none, p for trend 0.02), but no association in women.…”

“…One study based on residents in five geographic areas of Finland reported a hazard ratio (HR) of 0.40 (95% CI 0.23-0.71) for five cups of coffee per day or more versus none (p for trend 0.005) [481]. The Finnish Mobile…”

Genetic Mechanisms of Coffee Extract Protection in aCaenorhabditis elegansModel of β-Amyloid Peptide Toxicity

“…PIDEMIOLOGICAL studies have indicated that coffee consumption may be protective in Alzheimer's (AD) (Barranco Quintana et al 2007) and Parkinson's diseases (PD) (Hu et al 2007). Although a universal consensus on the cause(s) of Alzheimer's disease has not been reached, the best-supported hypotheses posit that accumulation of the b-amyloid peptide (Ab) is central to the induction of Alzheimer's disease pathology.…”

Tea and human health: biomedical functions of tea active components and current issues

“…The same risk for the population who drank 4-6 cups of green tea per week (or 1 cup green tea daily) was 38% lower than that in the population who did not drink tea (Kuriyama et al, 2006). A survey conducted in USA indicated that the risk of PD in the population who drank 2 cups or more of tea per day was decreased (Hu et al, 2007).…”