Coffee Consumption and the Risk of Cancer of the Exocrine Pancreas: A CaseʼControl Study in a Low-Risk Population

Lyon, Joseph L.; Mahoney, Arthur W.; French, Thomas K.; Moser, Royce

doi:10.1097/00001648-199203000-00015

Cited by 51 publications

(32 citation statements)

References 15 publications

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“…The lower rate of pancreatic cancer among the LDS women also may be explained by lower consumption of cigarettes and coffee among the LDS. 21 The lower than expected rate of cancer of the uterine cervix may be explained also by lower cigarette consumption and less sexual promiscuity among the LDS. 22 LDS women experienced a breast cancer rate well below that of the US (71.9 compared with 89.9) and of NLDS women (71.9 compared with 105.3).…”

Section: Discussionmentioning

confidence: 99%

Cancer incidence among Mormons and non-Mormons in Utah (United States) 1971–85

Lyon

Gardner

Gress

1994

Cancer Causes Control

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We calculated age-adjusted incidence rates per 100,000 by religion (Mormon, non-Mormon) for Utah (United States) using the 49,182 cancer cases occurring between 1971-85. For all causes of cancer, the rate in Utah for male members of the Church of Jesus Christ of Latter-day Saints (LDS or Mormons) was about 24 percent less than the comparable US rate. There was a 50-percent lower rate of cancers associated with cigarette smoking among LDS men. Non-LDS (NLDS) men in Utah experienced an incidence of smoking-associated cancers slightly higher than other US men. LDS men had an incidence of those cancers not associated with smoking slightly lower than US men, and NLDS men had a 40-percent higher rate than US men because of higher rates of melanoma and cancers of the lip and prostate gland. LDS women had an all-sites cancer rate 24 percent below the comparable US rate, and a 60-percent lower rate of smoking-associated cancers. The incidence of cancer not associated with smoking was 20 percent lower for LDS women compared with US women and was the result of lower rates of cancers of the colon, breast, and uterine cervix. NLDS women had a 13-percent higher incidence of cancers not associated with smoking because of higher rates of cancers of the lip and breast.

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Section: Discussionmentioning

confidence: 99%

Cancer incidence among Mormons and non-Mormons in Utah (United States) 1971–85

Lyon

Gardner

Gress

1994

Cancer Causes Control

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“…Silverman et a1 (58) found an increased risk among heavy alcohol drinkers in the United States, particularly among black nonsmokers. Twentytwo studies with a reasonable power to detect a positive association between alcohol consumption and the risk of pancreatic cancer failed to do so (15,16,18,19,26,30,34,35,37,39,40,41,43,46,48,(59)(60)(61)(62)(63)(64)(65). On occasion the excess may have been a result of confounding by tobacco smoking (34).…”

Section: Alcoholic Beveragesmentioning

confidence: 99%

“…Twentytwo studies with a reasonable power to detect a positive association between alcohol consumption and the risk of pancreatic cancer failed to do so (15,16,18,19,26,30,34,35,37,39,40,41,43,46,48,(59)(60)(61)(62)(63)(64)(65). On occasion the excess may have been a result of confounding by tobacco smoking (34). It has been suggested that beer (25,27,47,63,66) or whisky (56), both of which contain higher nitrosamine levels than other alcoholic beverages (67), increase the risk of pancreatic cancer.…”

Section: Alcoholic Beveragesmentioning

confidence: 99%

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Occurrence, trends and environmental etiology of pancreatic cancer

Weiderpass¹,

Partanen²,

Kaaks³

et al. 1998

Scand J Work Environ Health

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This review summarizes data on the occurrence, the trends, and the life-style, environmental, occupational and genetic determinants of pancreatic cancer. Epidemiologic evidence implicates tobacco smoking as one cause. The evidence regarding alcohol consumption is inconsistent. Although both positive and inconclusive findings are encountered, the bulk of the evidence on coffee consumption is negative. Fat intake is linked with obesity and diabetes mellitus, which are risk factors for pancreatic cancer. Fruit and vegetable consumption appears to be protective. No occupational or environmental agent has been confirmed to increase the risk, but epidemiologic evidence is inconsistent. Little is known about the role of genetic polymorphisms of metabolic enzymes in pancreas carcinogenesis. Pancreatic cancer shows high rates of mutations of Ki-ras and losses or mutations of tumor suppressor genes (p53, p16'NK4A, and SMAD4PDPC-4). Ki-ras mutations have been associated with life-style factors in relation to pancreatic cancer, but the evidence is still scant and inconsistent.Key terms environmental exposure, epidemiology, occupational exposure, pancreatic neoplasms, rewiew, risk factors.A total of 181 000 new cases of pancreatic cancer (International Classification of Diseases: code 157 in 9th revision and code C25 in 10th revision) are annually diagnosed worldwide (1). Owing to its high fatality, pancreatic cancer is the 5th leading cause of cancer deaths in industrialized nations. Most pancreatic cancers derive from the exocrine component. Endocrine tumors arising in islet cells constitute about 5% of all pancreatic cancers (2).The causes of pancreatic cancer are obscure for the most part. This review summarizes data on the occurrence, the trends, and the life-style, environmental, occupational and genetic determinants of exocrine pancreatic cancer. Descriptive epidemiologyBecause of the rapid fatality from pancreatic cancer, its incidence and mortality rates follow each other closely ' and increase steeply among people 40-70 years of age.

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“…Tobacco use and coffee consumption are recognized to increase the relative risk of pancreatic cancer, but the relationship between alcohol consumption and pancreatic cancer is less clear. [3][4][5][6][7] However, the contribution of dietary factors is well-recognized, and numerous epidemiological case-control studies have been performed to explore the dietary factors influencing the risk of pancreatic cancer in Western countries. 6,[8][9][10][11][12][13][14] Reprint requests to: Y. Takeyama make a difference between the highest quartile and the lowest one in these populations.…”

mentioning

confidence: 99%

Dietary intake as a risk factor for pancreatic cancer in Japan: high cholesterol and low vitamin C diet

Takeyama

2005

J Gastroenterol

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Coffee Consumption and the Risk of Cancer of the Exocrine Pancreas: A CaseʼControl Study in a Low-Risk Population

Cited by 51 publications

References 15 publications

Cancer incidence among Mormons and non-Mormons in Utah (United States) 1971–85

Cancer incidence among Mormons and non-Mormons in Utah (United States) 1971–85

Occurrence, trends and environmental etiology of pancreatic cancer

Dietary intake as a risk factor for pancreatic cancer in Japan: high cholesterol and low vitamin C diet

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