Cognition and behavior at school entry in children with congenital hypothyroidism treated early with high-dose levothyroxine

Simoneau-Roy, J.; Marti, Sebastien; Deal, Cheri; Huot, Céline; Robaey, Philippe; Vliet, Guy Van

doi:10.1016/j.jpeds.2004.02.021

Cited by 77 publications

(32 citation statements)

References 27 publications

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“…Moreover, we have to point out that, according to the inclusion criteria, our CH patients were enrolled in the study only if their IQ was above the normal range limit to stress the influence of psychological adjustment and behaviour parameters also in CH patients with normal intellectual outcome. This selection may partly explain our results in disagreement with Simoneau-Roy et al (11), who found subtle but relevant differences in intellectual performances between CH patients and controls and between severe and moderate/mild forms of CH. However, at least in our cohort of selected CH patients, the age at the beginning of treatment and the initial T 4 dose did not seem to be the critical factors for the later intellectual outcome (Tables 1 and 2).…”

Section: Discussioncontrasting

confidence: 99%

“…This indicator of prenatal CH severity was preferred to neonatal FT 4 cutoff level according to pre-therapy serum FT 4 concentration (21), because it was considered a more reliable indicator of foetal thyroid hormone supply during the pregnancy (10,11,20). However, Table 1 shows that bone maturation at birth was related to FT 4 serum levels at confirmation; therefore, they were both good parameters for the estimation of prenatal CH severity.…”

Section: Subjectsmentioning

confidence: 99%

“…However, previous studies have indicated that children who receive early treatment for CH have a normal intelligence quotient combined with attention problems (2,3), motor deficits and defects in visuospatial skills, language and memory (4,5). Several studies have correlated these problems with the severity of CH and others with the timing in starting treatment (6)(7)(8)(9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

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Psychological and behavioural aspects in children and adolescents with congenital hypothyroidism diagnosed by neonatal screening: comparison between parents' and children's perceptions

Bisacchi¹,

Bal²,

Nardi³

et al. 2011

European Journal of Endocrinology

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Objective: To compare the psychological adjustment and behaviour of congenital hypothyroidism (CH) children and their parents with a control group. Study design: A cross-sectional study was carried out with 84 CH subjects diagnosed by neonatal screening (range 2.7-18.6 years), subdivided into four age groups: group 1 (2-5 years); group 2 (6-10 years); group 3 (11-13 years); and group 4 (14-18 years) and was compared with an age-matched control group. Patients were assessed using two questionnaires: Child Behaviour Checklist for parents and Youth Self-Report for children over 11 years of age. Results: In groups 1, 3 and 4, total score (TS), internalising score (ISZproblems within the self) and externalising score (ESZconflicts with other people) as reported by parents were not significantly different in CH patients and in controls. In group 2, parents of CH children showed values of TS (P!0.05), IS (P!0.05), ES (P!0.05) and scores on other scales significantly higher than controls. In self-reports of groups 3 and 4, the behavioural scales were not significantly different in CH patients and in controls. Conclusions: Paediatricians should be informed about the increased risk of the development of behavioural problems at primary school age in CH patients. At this age special attention should be paid to parental worries and anxiety. However, it can be reassuring for the patients and parents to know that the problems may be related to CH, and that they may spontaneously disappear.

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Section: Discussioncontrasting

confidence: 99%

Section: Subjectsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Psychological and behavioural aspects in children and adolescents with congenital hypothyroidism diagnosed by neonatal screening: comparison between parents' and children's perceptions

Bisacchi¹,

Bal²,

Nardi³

et al. 2011

European Journal of Endocrinology

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“…At delivery, cord blood was retrieved for thyroid function tests (TSH, FT 4 , free triiodothyronine (FT 3 ), and TRAb) and the neonates were examined by a pediatric endocrinologist who recorded predefined criteria (heart rate, congestive heart failure, goiter, hyperexcitability, fever, sweating, voracity, vomiting, weight gain, diarrhea, orbitopathy, hepatosplenomegaly, and jaundice 3 , and TSH were assayed at the same time points. TRAb was assayed on days 7, 15, and 30 in babies with positive TRAb on cord blood and weekly in those requiring ATD therapy.…”

Section: Methodsmentioning

confidence: 99%

“…Cardiac insufficiency is one of the major risks in these infants. Liver dysfunction (hepatitis and cholestatic jaundice), coagulopathy, pulmonary arterial hypertension, craniostenosis, microcephaly, and psychomotor disabilities may occur in severely affected infants (4,5,6,7). Fetal thyroid dysfunction precedes neonatal hyperthyroidism.…”

Section: Introductionmentioning

confidence: 99%

Management of neonates born to women with Graves' disease: a cohort study

Besançon

Beltrand

Gac

et al. 2014

European Journal of Endocrinology

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Objective: Hyperthyroidism in neonates born to mothers with Graves' disease (GD) can be associated with significant morbidity and mortality, but is still overlooked by clinicians. Management of neonatal hyperthyroidism would be improved by a better understanding of the predictive factors involved. The aim of this study was to evaluate the course of thyroid function and clinical outcomes during the first postnatal month in babies born to mothers with GD. Design: Prospective observational study. Methods: Sixty-eight neonates born to mothers with GD were managed from birth and divided into three groups based on thyrotropin receptor antibody (TRAb) and anti-thyroid drug (ATD) status in the mother: TRAb /ATDCve neonates, 24 (72.7%) had positive TRAb on cord blood assays, and seven of these developed neonatal hyperthyroidism. FT 4 elevation between days 3 and 7 but not at birth was predictive of the development of hyperthyroidism. Conclusions: TRAb status should be checked in the third trimester in mothers with GD and on cord blood in their neonates; if positive, it indicates a high risk of neonatal hyperthyroidism. FT 4 measurement at birth should be repeated between days 3 and 5 (and by day 7 at the latest); rapid FT 4 elevation during the first postnatal week is predictive of hyperthyroidism and warrants ATD therapy.

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High versus low dose of initial thyroid hormone replacement for congenital hypothyroidism

Anand

Weindling

2009

Cochrane Database of Systematic Reviews

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Cognition and behavior at school entry in children with congenital hypothyroidism treated early with high-dose levothyroxine

Cited by 77 publications

References 27 publications

Psychological and behavioural aspects in children and adolescents with congenital hypothyroidism diagnosed by neonatal screening: comparison between parents' and children's perceptions

Psychological and behavioural aspects in children and adolescents with congenital hypothyroidism diagnosed by neonatal screening: comparison between parents' and children's perceptions

Management of neonates born to women with Graves' disease: a cohort study

High versus low dose of initial thyroid hormone replacement for congenital hypothyroidism

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