2023
DOI: 10.1101/2023.11.02.23297924
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Cognitive and inflammatory heterogeneity in severe mental illness: Translating findings from blood to brain

Linn Sofie Sæther,
Attila Szabo,
Ibrahim A. Akkouh
et al.

Abstract: Recent findings link cognitive impairment and inflammatory-immune dysregulation in schizophrenia (SZ) and bipolar (BD) spectrum disorders. However, heterogeneity and translation between the periphery and central (blood-to-brain) mechanisms remains a challenge. Starting with a large SZ, BD and healthy control cohort (n=1235), we aimed to i) identify candidate peripheral markers (n=25) associated with cognitive domains (n=9) and elucidate heterogenous immune-cognitive patterns, ii) evaluate the regulation of can… Show more

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