Cognitive and psychomotor effects in males after smoking a combination of tobacco and cannabis containing up to 69 mg delta-9-tetrahydrocannabinol (THC)

Hunault, Claudine C.; Mensinga, Tjeert T.; Böcker, K.B.E.; Schipper, C. Maarten A.; Kruidenier, Maaike; Leenders, Marianne E. C.; Vries, Irma de; Meulenbelt, Jan

doi:10.1007/s00213-008-1440-0

Cited by 109 publications

(81 citation statements)

References 28 publications

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“…This might lead to non-compliance to the treatment. Studies which reported irreversible cognitive loss 17 and significant relationship between cognitive and psychomotor performance deficits and daily amount of consumption 18 support this finding. In our study, significant improvements in information processing, reaction time, and motor functions only one-month after quitting cannabis use may suggest negative impacts of cannabis on these cognitive functions and abilities.…”

Section: Discussionmentioning

confidence: 76%

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The Changes of the Cognitive and Psychomotor Functions in the Chronic Cannabis Users after a Month of Remission

Umut

Atagün

Evren

et al. 2016

Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychophar

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ABS TRACT:The changes of the cognitive and psychomotor functions in the chronic cannabis users after a month of remission Objective: In our study, it is aimed to investigate impacts of cannabis use on information processing and psychomotor functions and to examine changes in the cognitive functions at the end of abstinence over a month. Method:The study was initiated with 34 volunteer participants using cannabis at least over two years, directed by a forensic unit. 34 persons were assessed at admission and were planned to assess after a month of remission. As 14 participants discontinued the study 20 participants only were assessed again at the end Results: There was no statistically significant difference between participants continue to the treatment and those discontinue in terms of sociodemographic and clinical characteristics. The participants discontinue were using more daily cannabis dose. The auditory reaction time of the group continue to the treatment decreased statistically significantly after a month whereas there was no statistically significant difference in the visual reaction time. The scores of the AMIPB-A and AMIPB-B were detected statistically higher after a month compared to admission. The score of the dominant hand FTT after a month was detected statistically higher than that in admission whereas there was no statistically significant difference in the non-dominant hand score. Conclusion:Improvements in scores of AMIP-A, AMIP-B, FTT and auditory reaction time after one month of quitting cannabis suggest that cannabis use may impair cognitive functions such as information processing, reaction time and motor functions. We suggest that future studies to assess cognitive functions after either a shorter (i.e. 1 week) or a longer (i.e. 2 months) period of cannabis abstinence in larger samples may provide further useful data about the relationship between cannabis use and cognitive functions.

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Section: Discussionmentioning

confidence: 76%

“…For instance, deficits may be irreversible in heavy users 17 . In another study, it has been reported that cognitive and psychomotor performance involvements were proportional to daily amount of consumption 18 . In this study, reaction time and motor control worsened with increasing doses of THC.…”

Section: Introductionmentioning

confidence: 90%

The Changes of the Cognitive and Psychomotor Functions in the Chronic Cannabis Users after a Month of Remission

Umut

Atagün

Evren

et al. 2016

Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychophar

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“…Whether working memory is impaired by cannabis is less clear, possibly because of the wide range of different working memory tasks employed. Acute administration of THC, dronabinol, or nabilone affected working memory inconsistently across Sternberg, delayed matching to sample, spatial or numeric working memory, n-back, digit recall, and digit span tasks (36)(37)(38)(39)(40)42,43,(68)(69)(70)(71)(72)(73)(74)(75)(76)(77)(78). Similarly, chronic cannabis use was shown to impair working memory in young adults on immediate recall (79), verbal reasoning (80), and verbal n-back (81) working memory tasks, but not on spatial working memory (48,82) or digit span (52,53), whereas spatial working memory was impaired in adolescent users (46), suggestive of differential effects in the developing brain.…”

Section: Acute and Chronic Effects Of Cannabinoids On Cognitionmentioning

confidence: 99%

Acute and Chronic Effects of Cannabinoids on Human Cognition—A Systematic Review

Broyd

Hell

Beale

et al. 2016

Biological Psychiatry

546

395

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Cannabis use has been associated with impaired cognition during acute intoxication as well as in the unintoxicated state in long-term users. However, the evidence has been mixed and contested, and no systematic reviews of the literature on neuropsychological task-based measures of cognition have been conducted in an attempt to synthesize the findings. We systematically review the empirical research published in the past decade (from January 2004 to February 2015) on acute and chronic effects of cannabis and cannabinoids and on persistence or recovery after abstinence. We summarize the findings into the major categories of the cognitive domains investigated, considering sample characteristics and associations with various cannabis use parameters. Verbal learning and memory and attention are most consistently impaired by acute and chronic exposure to cannabis. Psychomotor function is most affected during acute intoxication, with some evidence for persistence in chronic users and after cessation of use. Impaired verbal memory, attention, and some executive functions may persist after prolonged abstinence, but persistence or recovery across all cognitive domains remains underresearched. Associations between poorer performance and a range of cannabis use parameters, including a younger age of onset, are frequently reported. Little further evidence has emerged for the development of tolerance to the acutely impairing effects of cannabis. Evidence for potential protection from harmful effects by cannabidiol continues to increase but is not definitive. In light of increasing trends toward legalization of cannabis, the knowledge gained from this body of research needs to be incorporated into strategies to minimize harm. Review Acute and Chronic Effects of Cannabinoids on Human Cognition-A Systematic ReviewSamantha J. Broyd, Hendrika H. van Hell, Camilla Beale, Murat Yücel, and Nadia Solowij ABSTRACT Cannabis use has been associated with impaired cognition during acute intoxication as well as in the unintoxicated state in long-term users. However, the evidence has been mixed and contested, and no systematic reviews of the literature on neuropsychological task-based measures of cognition have been conducted in an attempt to synthesize the findings. We systematically review the empirical research published in the past decade (from January 2004 to February 2015) on acute and chronic effects of cannabis and cannabinoids and on persistence or recovery after abstinence. We summarize the findings into the major categories of the cognitive domains investigated, considering sample characteristics and associations with various cannabis use parameters. Verbal learning and memory and attention are most consistently impaired by acute and chronic exposure to cannabis. Psychomotor function is most affected during acute intoxication, with some evidence for persistence in chronic users and after cessation of use. Impaired verbal memory, attention, and some executive functions may persist after prolonged abstinence, but persistenc...

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“…One of the study strengths is that approximately half of the study participants in this study were female. Many previous studies on the effect of MJ on cognition have either not included women 23,24 or included fewer women than men [25][26][27][28][29][30] .…”

Section: Discussionmentioning

confidence: 99%

Impact of marijuana use on self-rated cognition in young adult men and women

et al. 2014

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Background and Objectives-Marijuana (MJ) is a widely used substance that has been shown to impair cognition in laboratory settings. There is a growing number of medical marijuana dispensaries and state policies permitting the use of MJ in the United States. This study is a naturalistic study that explores the association of same day marijuana use on self-rated cognition in young adult men and women.

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Cognitive and psychomotor effects in males after smoking a combination of tobacco and cannabis containing up to 69 mg delta-9-tetrahydrocannabinol (THC)

Cited by 109 publications

References 28 publications

The Changes of the Cognitive and Psychomotor Functions in the Chronic Cannabis Users after a Month of Remission

The Changes of the Cognitive and Psychomotor Functions in the Chronic Cannabis Users after a Month of Remission

Acute and Chronic Effects of Cannabinoids on Human Cognition—A Systematic Review

Impact of marijuana use on self-rated cognition in young adult men and women

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