Cognitive deterioration and changes of P300 during total sleep deprivation

Abstract

The study was conducted to evaluate the cognitive deteriorations induced by sleep deprivation with the computerized neurocognitive tests and the P300 event-related potential. Thirty healthy college students (22 men, eight women) participated in the present study. Subjects remained awake for 38 h under continuous surveillance. In the morning and the evening of the two study days, the computerized neurocognitive tests and the P300 were performed. In vigilance test and reaction unit test, there were significant cognitive impairments during sleep deprivation. However, in the cognitrone test there was significant functional improvement, which might be due to the practice effect. The P300 latency was significantly prolonged and the amplitudes decreased during sleep deprivation. The cognitive impairment during 38 h of sleep deprivation was mainly in terms of vigilance and reaction time. In contrast, higher complex cognitive function such as fine perceptual analyses, visual discrimination and working memory might be not affected by 38 h of total sleep deprivation. The changes of P300 were significantly correlated with the results of vigilance and reaction unit tests but not with the cognitrone test. Taken together, these results suggest that the P300 changes that occur during sleep deprivation are a reflection of the decrement in vigilance, which prolongs reaction time.

Association of Sleep Difficulty with Kidney Disease Quality of Life Cognitive Function Score Reported by Patients Who Recently Started Dialysis

“…There is increasing evidence from experimental and epidemiologic studies in the general population that sleep quality is associated with cognitive function (5)(6)(7)(8)(9). Although pervasive sleep difficulty has been documented widely among dialysis patients (10 -14), we identified only one study that considered the potential association of sleep difficulty with cognitive function.…”

Evaluation of Cognitive Function Using Objective and Subjective Tests in the Obstructive Sleep Apnea Syndrome

“…In these patients, one or both of hypoxia and sleep deprivation seem to alter memory process, leading to increase in delay and decrease amplitude of P300 wave in the ERP recordings. Accordingly, it causes reduced vigilance and increased time to react (35)(36)(37). It was observed that latency decreased and amplitude increased.…”

Síndrome da apneia obstrutiva do sono e o potencial auditivo P300

“…Latency is associated to the interstimuli frequency to the individual's attention and concentration 15,25 . The studies which showed a significant delay in P300 latency had individuals with severe OSAS 13 , of sleep deprivation associated with forced awakeness 6 and because of their circadian cycle phase 17 . On the other hand, a study involving individuals with OSAS showed that the attention deficit is more severe in young people, when compared to elderly (threshold age: 50 years), and that age it does not interact with OSAS in worsening the cognitive deficit 26 .…”

“…Case-control clinical studies carried out with individuals subjected to a forced sleep deprivation showed latency extension and reduction in the auditory P300 amplitude in the study group. These results have suggested that the P300 changes in the study group were reflexes from lowering the state of awareness, which extends the reaction time [4][5][6] . The cognitive deterioration induced by sleep deprivation is a consequence of neurophysiological changes, demonstrated by reduction in amplitude and increase in P300 latency.…”