Cognitive development in children with chronic protein energy malnutrition

Kar, Bhoomika R.; Rao, Shobini L.; Chandramouli, Balasubramanian

doi:10.1186/1744-9081-4-31

Cited by 303 publications

(261 citation statements)

References 30 publications

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“…Recent studies show that children who failed to thrive in infancy are lighter and shorter at school age with adverse intellectual outcomes (Corbett and Drewett, 2004;Black et al, 2007;Emond et al, 2007;Kar et al, 2008). Weight faltering in the first few months of life is particularly associated with these adverse effects.…”

mentioning

confidence: 99%

Growth faltering: how to catch up?

Sullivan

Goulet²

2010

Eur J Clin Nutr

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mentioning

confidence: 99%

Growth faltering: how to catch up?

Sullivan

Goulet²

2010

Eur J Clin Nutr

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“…Early-onset FTT has been found to increase children's vulnerability to short stature, poor arithmetic performance and poor work habits (Black et al, 2007;Kar et al, 2008). Although the concept of FTT is widely used, no consensus exists regarding its specific definition.…”

Section: Monitoring Growthmentioning

confidence: 99%

“…Any imbalance can have both short-and long-term consequences. For example, Kar et al (2008) showed cognitive impairment in children with chronic protein energy malnutrition (Kar et al, 2008). In addition, protein depletion may affect prognosis with regard to liver transplants and tolerance to chemotherapy, and thus also the clinical outcomes.…”

Section: Main Cause Of Growth Falteringmentioning

confidence: 99%

Growth faltering: setting the scene

Goulet

2010

Eur J Clin Nutr

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“…Severe acute malnutrition (SAM) is a leading cause of global child mortality, is associated with growth faltering, and results in impaired cognitive development (Kar et al 2008). A significant proportion of deaths due to numerous illnesses including malaria, measles and diarrheal diseases have also been attributed to malnutrition (Caulfield et al 2004).…”

Section: Introductionmentioning

confidence: 99%

Metabolic derangements identified through untargeted metabolomics in a cross-sectional study of Nigerian children with severe acute malnutrition

et al. 2016

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Introduction: Severe acute malnutrition (SAM) is a major cause of child mortality worldwide, however the pathogenesis of SAM remains poorly understood. Recent studies have uncovered an altered gut microbiota composition in children with SAM, suggesting a role for microbes in the pathogenesis of malnutrition. Objectives: To elucidate the metabolic consequences of SAM and whether these changes are associated with changes in gut microbiota composition. Methods: We applied an untargeted multi-platform metabolomics approach (gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS)) to stool and plasma samples from 47 Nigerian children with SAM and 11 control children. The composition of the stool microbiota was assessed by 16S rRNA gene sequencing. Results: The plasma metabolome discriminated children with SAM from controls, while no significant differences were observed in the microbial or small molecule composition of stool. The abundance of 585 features in plasma were significantly altered in malnourished children (Wilcoxon test, FDR corrected P < 0.1), representing approximately 15% of the metabolome. Consistent with previous studies, children with SAM exhibited a marked reduction in amino acids/dipeptides and phospholipids, and an increase in acylcarnitines. We also identified numerous metabolic perturbations Powered by Editorial Manager® and ProduXion Manager® from Aries Systems Corporationwhich have not been reported previously, including increased disaccharides, truncated fibrinopeptides, angiotensin I, dihydroxybutyrate, lactate, and heme, and decreased bioactive lipids belonging to the eicosanoid and docosanoid family. Conclusion: Our findings provide a deeper understanding of the metabolic consequences of malnutrition. Further research is required to determine if specific metabolites may guide improved management, and/or act as novel biomarkers for assessing response to treatment. Powered by Editorial Manager® and ProduXion Manager® from Aries Systems CorporationDear Royston Goodacre, Editor-in-Chief MetabolomicsWe are very grateful for the valuable comments raised by the reviewers. Please see our responses below; we trust that these are appropriate. I have also attached a revised version of the manuscript with the changes highlighted.Please note that, in response to comments by reviewer 3, we have moved details of methodology to the main manuscript. This has increased the length of the manuscript but we trust that this is acceptable.Please do let me know if there are any remaining issues. Sincerely, Stephen AllenReviewer #1: This study is about metabolic derangements identified through untargeted metabolomics in a cross-sectional study of Nigerian children with severe acute malnutrition. It is an interesting and relevant study because studies investigating the pathogenesis of SAM are lacking. To this respect the study presented in the manuscript has some qualities, however as the authors point it out it has several limitations. Only the plasma samples gave some resu...

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Cognitive development in children with chronic protein energy malnutrition

Cited by 303 publications

References 30 publications

Growth faltering: how to catch up?

Growth faltering: how to catch up?

Growth faltering: setting the scene

Metabolic derangements identified through untargeted metabolomics in a cross-sectional study of Nigerian children with severe acute malnutrition

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