Cognitive Dysfunction in Patients with Systemic Lupus Erythematosus: A Controlled Study

Antonchak, Marc; Saoudian, Mahnaz; Khan, Amber; Brunner, Hermine I.; Luggen, Michael E.

doi:10.3899/jrheum.100560

Cited by 18 publications

(11 citation statements)

References 38 publications

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“…It has also contributed to different estimations of treatment success, debate over mechanisms, and controversy about whether neuropsychiatric illness is due to the chronic disease state itself, other end-organ dysfunction, treatments for SLE, or if it is a primary outcome. 2 …”

Section: Diagnostic Criteriamentioning

confidence: 99%

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Neuropsychiatric Symptoms in Lupus

Gulinello¹,

Wen²,

Putterman³

2012

Psychiatric Annals

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CME Educational Objectives 1. Learn the symptoms, diagnostic procedures, and prevalence of neuropsychiatric lupus (NPSLE). 2. Understand the current hypotheses regarding the putative mechanisms underlying NPSLE. 3. Become familiar with some of the current strategies for treatment of NPSLE and understand their limitations. The neuropsychiatric aspects of systemic lupus erythematosus have been less studied than the peripheral aspects of the disease, and the importance of neuropsychiatric symptoms has been underestimated. Furthermore, until recently, the diagnostic criteria were not standardized and were not sufficiently based on systematic evidence from preclinical and clinical data.

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Section: Diagnostic Criteriamentioning

confidence: 99%

“…Furthermore, several lines of evidence indicate that NPSLE symptoms can be primary manifestations of central inflammatory disease rather than simply outcomes of end-organ dysfunction and/or treatment. 2,15 …”

Section: Symptoms Of Npslementioning

confidence: 99%

Neuropsychiatric Symptoms in Lupus

Gulinello¹,

Wen²,

Putterman³

2012

Psychiatric Annals

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“…Furthermore, no population-based normative data matched to the HF patients’ demographics—especially with regards to age—currently exist for the ANAM, which evaluates CI based on the number of standard deviations that an individual's scores fall below the mean ANAM efficiency scores of an appropriate control population. 63 Until adequate norms are established or further studies are conducted with appropriate age-matched control groups in comparison to HF patients, the present study may need to be replicated in a larger sample to determine whether age significantly impacts the utility of the ANAM. In addition, although patients were informally monitored for fatigue, anxiety, and any difficulty with computer usage, these factors were not formally controlled for or assessed as covariates in the analyses and may impact performance.…”

Section: Discussionmentioning

confidence: 94%

Performance of the Automated Neuropsychological Assessment Metrics (ANAM) in detecting cognitive impairment in heart failure patients

et al. 2015

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Objective Evaluate capacity of the Automated Neuropsychological Assessment Metrics (ANAM) to detect cognitive impairment (CI) in heart failure (HF) patients. Background CI is a key prognostic marker in HF. Though the most widely used cognitive screen in HF, the Mini-Mental State Examination (MMSE) is insufficiently sensitive. The ANAM has demonstrated sensitivity to cognitive domains affected by HF, but has not been assessed in this population. Methods Investigators administered the ANAM and MMSE to 57 HF patients, compared against a composite model of cognitive function. Results ANAM efficiency (p < .05) and accuracy scores (p < .001) successfully differentiated CI and non-CI. ANAM efficiency and accuracy scores classified 97.7% and 93.0% of non-CI patients, and 14.3% and 21.4% with CI, respectively. Conclusions The ANAM is more effective than the MMSE for detecting CI, but further research is needed to develop a more optimal cognitive screen for routine use in HF patients.

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“…ANAM categorizes an individual"s results as equal to, above, or below average performance, and this outcome can be assessed further to help determine whether the individual has suffered a brain or other injury or illness (C-SHOP, 2008;Antonchak, Saoudian, Khan, Brunner, & Luggen, 2011;Kane, Roebuck-Spencer, Short, Kabat, & Wilken, 2007;Levinson, Reeves, Watson, & Harrison, 2005). As is the case with other neuropsychological test batteries, ANAM is used to collect pre-injury baseline data at the beginning of a sport season.…”

Section: Automated Neuropsychological Assessment Metricsmentioning

confidence: 99%

“…ANAM results for learning and memory were related to decreases in perfusion, a potential marker for mild brain injury (Liu, Li, Quartermain, Boutajangout, & Ji, 2013). ANAM has been used for assessing other neurological conditions, such as systemic lupus erythematosus, multiple sclerosis, and degenerative diseases (Antonchak et al, 2011;Kane et al, 2007;Levinson et al, 2005).…”

Section: Automated Neuropsychological Assessment Metricsmentioning

confidence: 99%

Pre-injury variables and risk of sport concussion

Mylabathula

2017

Br J Sports Med

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ObjectiveThe study examined whether cognitive functioning, history of concussion (HOC), and sex predicted risk of sport concussion.DesignRetrospective study design. Predictive models were used to determine the predictive ability of each variable.SettingCanadian University.Participants708 data observations from 701 varsity athletes (41.2% female), representing 14 sports.Assessment of risk factorsTwo measures of cognitive functioning (mean reaction time and throughput [speed and accuracy]) were assessed using the Automated Neuropsychological Assessment Metrics testing battery. Categorical and continuous measures of HOC, and sex, were examined.Outcome measuresOccurrence of concussion after baseline testing.Main resultsHOC was a significant predictor for both sexes. For every previous concussion, the odds of sustaining another concussion increased by 1.5 (95% Confidence Interval [CI]: 1.1, 2.1 [females]; 1.2, 1.9 [males]). Females with a HOC had twice the odds of sustaining another concussion than those without a HOC (CI: 1.1, 4.0). For males, the odds were three times (CI: 1.7, 5.6). Cognitive functioning and sex were not meaningful predictors.ConclusionsThis study supports previous findings that HOC is a risk factor and suggests that pre-injury cognitive functioning is not a risk factor for sport concussion. Assessing HOC in all athletes prior to their competitive season provides information regarding their risk of future sport concussion. Thus, it is important for clinicians to record HOC, and to encourage athletes to report concussions to ensure an accurate HOC record. Pre-injury cognitive screening of athletes is not recommended for assessing risk of future concussion.Competing interests Sandhya Mylabathula, Lynda Mainwaring, and Michael Hutchison None. Doug Richards is the Medical Director at the MacIntosh Sports Medicine Clinic at the University of TorontoPaul Comper is a clinical neuropsychologist consultant with the NHLPA and a member of the Concussion Working Group, but neither were related to the current research

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Cognitive Dysfunction in Patients with Systemic Lupus Erythematosus: A Controlled Study

Abstract: We found no differences in cognitive function between patients with SLE and RA, suggesting that the CD found in some patients with SLE may represent the consequences of a chronic and/or inflammatory disease rather than SLE-related central nervous system damage.

Cited by 18 publications

References 38 publications

Neuropsychiatric Symptoms in Lupus

Neuropsychiatric Symptoms in Lupus

Performance of the Automated Neuropsychological Assessment Metrics (ANAM) in detecting cognitive impairment in heart failure patients

Pre-injury variables and risk of sport concussion

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