Cognitive Dysfunction in the Overexcitation of Brain Structures

Волобуев, А. Н.; Pyatin, V. F.; Romanchuk, N.; Bulgakova, S.; Давыдкин, И. Л.

doi:10.29296/25877305-2018-09-04

Cited by 22 publications

(7 citation statements)

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“…Нейроваскулярные связи нарушаются в определенных неврологических условиях. Необходимо, установить как сердечно-сосудистые заболевания могут повлиять на регуляцию CBF и нейроваскулярные связи [1][2][3][4][5][6][7].…”

Section: биофизика и нейрофизиология сосудистой деменции и болезни алunclassified

“…Нами, экспериментально и 25-летними наблюдениями было показано, что длительно существующее состояние гипоперфузии приводит к гиппокампальным нарушениям. Этот процесс сопровождается нарушениями памяти, структурным изменением капилляров в области гиппокампа, нарушением обмена глюкозы и белков, отложением βамилоида, активацией глиальной ткани, гибелью нейронов гиппокампа [1][2][3][4][5][6][7][14][15][16].…”

Section: клинико-биофизические принципы лечения сосудистой деменции иunclassified

“…Развивается сенильная сосудистая деменция. При раннем обнаружении начавшихся патологических процессов, необходимо проведение лечебных мероприятий, направленных на восстановление церебрального кровотока или, по крайней мере, замедление патологических процессов [1][2][3][4][5][6][7].…”

Section: клинико-биофизические принципы лечения сосудистой деменции иunclassified

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Clinical and Biophysical Principles of Vascular Dementia and Alzheimer’s Disease Treatment

Bulgakova

Romanchuk

Волобуев

2019

BSP

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Biophysics of blood circulation in Alzheimer’s disease is characterized by disorders of laminar blood flow and cerebral hypoperfusion. As a result, failure intracellular metabolism, there is a cascade of changes in neurons associated with the processes of excitotoxicity and oxidant stress, which in turn stimulates amyloidogenesis. Experimental and 25-year observations have shown that the long-existing state of hypoperfusion leads to hippocampal disorders. This process is accompanied by memory impairment, structural changes in the capillaries in the hippocampus, impaired glucose and protein metabolism, β–amyloid deposition, activation of glial tissue, death of hippocampal neurons. Neuroreflex disruption in the ‘cerebral heart’ and a violation of cerebrovascular homeostasis contributes to the development of vascular dementia through the following mechanisms, including cerebral microangiopathy, endothelial dysfunction, oxidative stress, neuronal damage, the increase in β–amyloid neurotoxicity, apoptosis, etc. The duration of therapy with antiglutamatergic and multimodal drugs in Alzheimer’s disease requires constant multidisciplinary monitoring of targets and medical and social control in the system of long-term care. Lifelong acquisition of knowledge, information positive Nano communication enable the preservation of mental health and active longevity. Innovative methods of P4-medicine of neuroplasticity management allow to carry out timely prevention of the factors reducing neuroplasticity, to keep factors of positive influence on visceral and cognitive brain, and the main thing — in due time to apply in practical health care the combined methods of preservation and development of the human cognitive brain.

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Section: биофизика и нейрофизиология сосудистой деменции и болезни алunclassified

Section: клинико-биофизические принципы лечения сосудистой деменции иunclassified

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Clinical and Biophysical Principles of Vascular Dementia and Alzheimer’s Disease Treatment

Bulgakova

Romanchuk

Волобуев

2019

BSP

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“…Прежде всего, мозг использует детерминированные связи, возникающие в виде облегченных путей проведения возбуждения между нейронами, вследствие наличия предыдущего опыта (обучения). Схема перцептрона, на которой в основном базируются современные искусственные нейронные сети, представляет собой полностью детерминированную систему [35][36][37].…”

Section: болезнь альцгеймера и искусственный интеллектunclassified

“…Предполагаем, что в каждом узле двумерной сетки находится ЦНЦ. Все ЦНЦ связаны между собой, что отражается сплошными линиями [35][36][37]. Остальные сопротивления можно найти, используя формулу [7]: e R d e R R im im im mm 0 2 1 2 1 2 2 2 1 sin 1 2 2 1 sin 1 2 cos 1 2 2 1 Полученные результаты вряд ли можно считать полностью адекватными, т.к.…”

Section:  unclassified

Alzheimer’s Disease and Artificial Intelligence: Long-term Personalized Rehabilitation and Medical and Social Support

Bulgakova

Romanchuk

et al. 2019

BSP

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Modern technologies and tools for the rehabilitation of patients with Alzheimer’s disease have many potential applications for the treatment of dementia from diagnosis and evaluation to medical care, medical, social and economic support: from healthy aging, to accelerated and pathological aging of Homo sapiens. Doctor and neuroscientist: a modern solution to problems of rehabilitation ‘cognitive brain’ of Homo sapiens using on the one hand, tools and technologies of artificial intelligence, and with another — a multidisciplinary collaboration with clinical neurophysiologist ‘universal’ specialist in the field of neurology, psychiatry, psychotherapy, psychoanalysis and geriatrics. Systems biology, Biophysics, physiology, neurophysiology and highlight the multidimensional and combinatorial profiles of genetic, biological, pathophysiological and clinical biomarkers that reflects the heterogeneity of neurodegeneration, by means of modern efficient analysis tools to register and create comprehensive maps of the brain and recording of dynamic models in different systems: from molecules to neurons to brain regions. Bioinformatics, neuroimaging and neurophysiology of systems are aimed at calculating neural network models of the relationship between structure and dynamic function in brain networks. Structural and functional markers of the brain establish a link between clinical phenotypes and molecular pathophysiological mechanisms. Phenotypic variability is now considered one of the biggest problems in gerontology and geriatrics. MRI imaging to detect subtle changes in brain tissue and structure, fMRI imaging to measure changes in brain activity, and EEG to measure electrical activity have given clinicians many new insights into what happens in the brain in healthy and pathological aging. The paradigm of system neurophysiology is aimed at studying the fundamental principles of functioning of integrated neural systems through the integration and analysis of neural information recorded in a multimodal way (for example, fMRI and EEG), through computational modeling and combining data mining methods. The ultimate goal of systemic neurophysiology is to find out how signals are represented in neocortical networks and what role many different neural components play. Modern artificial intelligence technologies are capable of many things, including predicting Alzheimer's disease with the help of combined and hybrid neuroimaging, sequencing of a new generation, etc., in order to start timely and effective rehabilitation brain Homo sapiens.

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Science of Cognitive Brain and Quantum Biophysics Homo sapiens 21st Century: hybrid Neuroimaging and Nuclear medicine, 5P Medicine and 5G Technology, Neurobiology and Neurophysiology of Quantum Brains, Psychoanalysis, Art-Medicine, Bioelementology and Nutriciology

Volobuev,

Romanchuk,

Romanchuk

et al. 2024

Bulletin of Science and Practice

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New discoveries in the field of genetics and epigenetics, the scientific union of neurobiology and neurophysiology of the quantum brain Homo sapiens of the 21st century, the achievements of biophysics, hybrid neuroimaging and nuclear medicine, the introduction of nutritionology and bioelementology technologies, the 5P of Medicine and 5G Technology, the replication of compliance of art medicine and modern psychoanalysis made it possible to manage 21st century Human cognitive brain. Scientific progress and 33 years of experimental experience of biophysics in the field of neurogeriatrics and neurocardiology, neuroendocrinology and psychoneuroimmunology made it possible to argue that “nerve cells are restored”, the quantum human brain is Controlled, high-quality and healthy longevity Homo sapiens of the 21st century is achievable. Humankind needs to know (discover, prove) in the near future the existence of more than 450 trillion neurosynaptic and neurocosmic interactions between the cognitive mind and the universe.

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Cognitive Dysfunction in the Overexcitation of Brain Structures

Cited by 22 publications

References 0 publications

Clinical and Biophysical Principles of Vascular Dementia and Alzheimer’s Disease Treatment

Clinical and Biophysical Principles of Vascular Dementia and Alzheimer’s Disease Treatment

Alzheimer’s Disease and Artificial Intelligence: Long-term Personalized Rehabilitation and Medical and Social Support

Science of Cognitive Brain and Quantum Biophysics Homo sapiens 21st Century: hybrid Neuroimaging and Nuclear medicine, 5P Medicine and 5G Technology, Neurobiology and Neurophysiology of Quantum Brains, Psychoanalysis, Art-Medicine, Bioelementology and Nutriciology

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