Cognitive efficiency is associated with endogenous cytokine levels in patients with chronic hepatitis C

Hilsabeck, Robin C.; Anstead, Gregory M.; Webb, Amy; Hoyumpa, Anastasio; Ingmundson, Paul; Holliday, Steve; Zhang, Qiong; Casas, Ángela; Jovel, Marci; Stern, Stephen L.

doi:10.1016/j.jneuroim.2010.01.017

Cited by 30 publications

(21 citation statements)

References 82 publications

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“…This finding suggests that severity of infection may contribute to impulsivity and decision-making; however, more research is needed to disentangle possible confounding variables such as drug use and exposure. Although the present study did not analyze inflammatory markers in relation to imaging findings and cannot confirm causative mechanisms, results are generally consistent with other studies demonstrating that viral load and peripheral inflammatory factors (e.g., cytokines, chemokines) are related to HCV-associated neuropsychiatric symptoms (Loftis, Huckans et al 2008, Hilsabeck, Anstead et al 2010, de Almeida, de Lima et al 2011, Huckans, Fuller et al 2014). …”

Section: Discussionsupporting

confidence: 91%

Functional MRI and delay discounting in patients infected with hepatitis C

McCready

Kohno

Kolessar³

et al. 2018

J. Neurovirol.

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Background: Hepatitis C virus infected (HCV+) adults evidence increased rates of psychiatric and cognitive difficulties. This is the first study to use functional magnetic resonance imaging (fMRI) to examine brain activation in untreated HCV+ adults. Objective: To determine whether, relative to non-infected controls (CTLs), HCV+ adults exhibit differences in brain activation during a delay discounting task (DDT), a measure of one’s tendency to choose smaller immediate rewards over larger delayed rewards - one aspect of impulsivity. Methods: 20 adults with HCV and 26 CTLs completed an fMRI protocol during the DDT. Results: Mixed effects regression analyses of Hard versus Easy trials of the DDT showed that, compared with CTLs, the HCV+ group exhibited less activation in the left lateral occipital gyrus, precuneus and superior frontal gyrus. There were also significant interactive effects for Hard – Easy contrasts in the bilateral medial frontal gyrus, left insula, left precuneus, left inferior parietal lobule, and right temporal occipital gyrus; the CTL group evidenced a positive relationship between impulsivity and activation, while the HCV+ group exhibited a negative relationship. Within the HCV+ group, those with high viral load chose immediate rewards more often than those with low viral load, regardless of choice difficulty; those with low viral load chose immediate rewards more often on hard choices relative to easy choices. Conclusions: Results show that HCV+ patients exhibit greater impulsive behavior when presented with difficult choices, and impulsivity is negatively related to activation in regions important for cognitive control. Thus, interventions that decrease impulsive choice may be warranted with some HCV+ patients.

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Section: Discussionsupporting

confidence: 91%

Functional MRI and delay discounting in patients infected with hepatitis C

McCready

Kohno

Kolessar³

et al. 2018

J. Neurovirol.

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“…There is substantial evidence that aging is associated with increases in peripheral immune gene upregulation and that this is, in turn, associated with cognitive dysfunction (Gimeno and others 2008; Hilsabeck and others 2010; Rafnsson and others 2007; Reichenberg and others 2001; Rothenburg and others 2010; Tonelli and Postolache 2005). To address this possibility in the current experiment, we examined levels of pro-inflammatory cytokines in the serum of mice from Cohorts 1 and 3.…”

Section: Resultsmentioning

confidence: 99%

Parallel declines in cognition, motivation, and locomotion in aging mice: Association with immune gene upregulation in the medial prefrontal cortex

Bordner

Kitchen

Carlyle

et al. 2011

Experimental Gerontology

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Aging in humans is associated with parallel changes in cognition, motivation, and motoric performance. Based on the human aging literature, we hypothesized that this constellation of age-related changes is mediated by the medial prefrontal cortex and that it would be observed in aging mice. Toward this end, we performed detailed assessments of cognition, motivation, and motoric behavior in aging mice. We assessed behavioral and cognitive performance in C57Bl/6 mice aged 6, 18, and 24 months, and followed this with microarray analysis of tissue from the medial prefrontal cortex and analysis of serum cytokine levels. Multivariate modeling of these data suggested that the age-related changes in cognition, motivation, motor performance, and prefrontal immune gene expression were highly correlated. Peripheral cytokine levels were also correlated with these variables, but less strongly than measures of prefrontal immune gene upregulation. To determine whether the observed immune gene expression changes were due to prefrontal microglial cells, we isolated CD11b-positive cells from the prefrontal cortex and subject them to next-generation RNA sequencing. Many of the immune changes present in whole medial prefrontal cortex were enriched in this cell population. These data suggest that, as in humans, cognition, motivation, and motoric performance in the mouse change together with age and are strongly associated with CNS immune gene upregulation.

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“…These include obesity (Miller and Spencer, 2014), HIV infections (Correia et al, 2013;Hilsabeck et al, 2010), healthy older adults (Elderkin-Thompson et al, 2012;Noble et al, 2010;Simpson et al, 2013), chemotherapy (Cheung et al, 2013;Ganz et al, 2013;Kesler et al, 2013), heart failure (Athilingam et al, 2013), RA (Hamed et al, 2012), hepatitis C virus infection (Farag et al, 2011) and bipolar disorder (Bauer et al, 2014;Lotrich et al, 2014).…”

Section: Cognitive and Memory Difficulties And Inflammationmentioning

confidence: 99%