Cognitive Enhancing Effects of Alpha Asarone in Amnesic Mice by Influencing Cholinergic and Antioxidant Defense Mechanisms

N-palmitoyl serotonin alleviates scopolamine-induced memory impairment via regulation of cholinergic and antioxidant systems, and expression of BDNF and p-CREB in mice

“…Meanwhile, the administration of Pal-5HT significantly enhanced antioxidant defense by suppressing the increase of lipid peroxidation and the decrease of GSH level in the brain of mice treated with scopolamine. Furthermore, the treatment with Pal-5HT significantly reversed the scopolamine-mediated decrease in activities of antioxidant enzymes such as GPx and GR, consistent with the previous studies[25,46]. In addition, in the analysis about the expression of antioxidant enzymes mediated via Nrf2 activation, the decreased expression of NQO1 in the hippocampus of mice treated with scopolamine was…”

Traditional Korean East Asian Medicines and Herbal Formulations for Cognitive Impairment

“…Several studies have shown the cognitive enhancing effects of this plant. In our lab, α-asarone showed a reversal of scopolamine-induced amnesia, and inhibited AChE activity in vivo [70]. Chong-Myung-Tang (CMT) which consists of A. gramineus, Polygala tenuifolia, and Poria cocos, is one of the TKMs used for the therapy of learning and memory improvement.…”

<i>Indigofera tinctoria</i> Linn (Fabaceae) attenuates cognitive and behavioral deficits in scopolamine-induced amnesic mice

“…Experimental sessions were conducted using GEMINI active and passive avoidance system (San Diego Instruments, San Diego, CA, USA) connected to a computer as described earlier [13]. The instrument has a bright and a dark compartment with a computer-controlled guillotine door between them.…”

“…Each arm was 40 cm long, 12 cm wide and 30 cm high. The procedure was similar as described previously [13]. Each mouse, naïve to the maze, was placed at the end of one arm and allowed to move freely through the maze during an 8 m session, and arm entries were counted.…”