Cognitive Impairment in Multiple Sclerosis

Trenova, Anastasiya G.; Slavov, G; Manova, Maria G.; Aksentieva, Jana B.; Miteva, Lyuba; Stanilova, Spaska

doi:10.1515/folmed-2016-0029

Cited by 35 publications

(26 citation statements)

References 43 publications

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“…Although clinical phenotypes may differ in the prevalence or severity of cognitive impairment, main determinants are physical disability as measured by EDSS, and patients’ age [35]. Other individual characteristics such as gender, genetic factors, and cognitive reserve may also play a relevant role [36]. For a summary of the most frequent cognitive domains affected in MS see Table 1.…”

Section: Cognitive Domainsmentioning

confidence: 99%

“…It is the most consistently affected cognitive domain in MS patients. Impaired learning of new information seems to be the primary problem [36], but the encoding, storing, and retrieval from long-term storage processes of memory seems to be affected in MS patients, so there is still controversy about which of these components of memory is the most influential factor for explaining memory deficits [40]. Other factors, such as slow processing speed, susceptibility to interference, executive disfunction, and perceptual deficits can also determine poor learning abilities [41].…”

Section: Cognitive Domainsmentioning

confidence: 99%

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Assessment and Impact of Cognitive Impairment in Multiple Sclerosis: An Overview

2019

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Cognitive impairment affects 40–60% of patients with multiple sclerosis. It may be present early in the course of the disease and has an impact on a patient’s employability, social interactions, and quality of life. In the last three decades, an increasing interest in diagnosis and management of cognitive impairment has arisen. Neuropsychological assessment and neuroimaging studies focusing on cognitive impairment are now being incorporated as primary outcomes in clinical trials. However, there are still key uncertainties concerning the underlying mechanisms of damage, neural basis, sensitivity and validity of neuropsychological tests, and efficacy of pharmacological and non-pharmacological interventions. The present article aimed to present an overview of the assessment, neural correlates, and impact of cognitive impairment in multiple sclerosis.

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Section: Cognitive Domainsmentioning

confidence: 99%

Section: Cognitive Domainsmentioning

confidence: 99%

Assessment and Impact of Cognitive Impairment in Multiple Sclerosis: An Overview

2019

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“…We are, however, confident in the observed results because our sample size matches previous studies on dual-task walking reliability in persons with MS 21,22 and recommendations on reliability in neurological patients made by Hobart et al 27 Importantly, current results are comparable to those of previous studies in neurological populations. The 3 cognitive tasks used in the current study were based on the cognitive domains involved-namely, information processing speed, working memory, and attention because these are frequently impaired in pwMS 40 -and on previous studies. Tasks of executive functioning such as the Stroop color word task and verbal fluency tasks have, however, also been shown to be promising concurrent cognitive tasks in pwMS 13,56 and showed excellent test-retest reliability in a dual balancing task.…”

Section: Limitationsmentioning

confidence: 99%

Test-Retest Reliability of Cognitive-Motor Interference Assessments in Walking With Various Task Complexities in Persons With Multiple Sclerosis

Veldkamp

Romberg²,

Hämäläinen³

et al. 2019

Neurorehabil Neural Repair

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Background: Simultaneous execution of motor and cognitive tasks can result in worsened performance on one or both tasks, indicating cognitive motor interference (CMI). A growing amount of research on CMI in persons with Multiple Sclerosis (pwMS) is observed. However, psychometric properties of dual-task outcomes have been scarcely reported.Objective: To investigate the between-day test-retest reliability of the motor and cognitive dual-task costs (DTC) during multiple CMI test conditions with various task complexity in pwMS and matched healthy controls (HC).Methods: 34 pwMS (Expanded Disability Status Scale score 3.0±0.8) and 31 HCs were tested and retested on three single cognitive, four single motor and twelve cognitivemotor dual-tasks. Cognitive tasks included serial subtraction by seven, titrated digit span backwards and auditory vigilance. Motor tasks were walking: at self-selected speed, over obstacles, crisscross and while carrying a water-filled cup. Outcome measures were cognitive and motor DTC, calculated as percentage change of dualtask performance compared to single-task performance. Intraclass correlations (ICCs) and Spearman correlation coefficients were calculated as appropriate.Results: For DTCmotor of gait speed, ICCs ranged from 0.45 to 0.81 and Spearman correlations from 0.74 to 0.82. For DTCcognitive, ICCs ranged from -0.18 to 0.49 and Spearman correlations from -0.28 to 0.26. Reliability depended on the type of motor and cognitive task.Conclusion: Reliability of the DTCmotor was, overall, good, while that of the DTCcognitive was poor. The 'walking' and 'cup' dual-task conditions were the most reliable regardless of the integrated cognitive task.3

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“…Of particular significance is the high prevalence of cognitive symptoms in patients diagnosed with MS, which impacts overall quality of life [4]. Cognitive symptoms can be one of the earliest symptoms and are present in up to 70% of patients [5, 6]. In fact, cognitive impairments in particular as well as depression, fatigue, and motor function resulting from MS have been shown to contribute to lowered work performance [7] and increased unemployment rates [8–11], reduced social activities [12], long-term disability [10], mental health [13], and overall quality of life [14].…”

Section: Introductionmentioning

confidence: 99%

The Relationship between Psychosocial Factors and Cognition in Multiple Sclerosis

Alosaimi

AlMulhem

Moscovici

et al. 2017

Behavioural Neurology

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Introduction Multiple sclerosis (MS) is a common disorder in some regions of the world, with over 2.3 million people diagnosed worldwide. Cognitive impairment is one of the earliest symptoms to present in the course of the disease and can cause significant morbidity. We proposed a study to explore the psychosocial predictors of cognitive impairment in MS patients in Saudi Arabia, a previously unexplored patient population. Methods Demographic data, depression scale (PHQ9), symptom burden (PHQ15), anxiety (GAD7), disease duration, and Montreal Cognitive Assessment (MOCA) scores were collected from 195 patients in a neurology clinic in Ryiadh, Saudi Arabia. Univariate and multiple regression analyses were conducted to identify variables that are significantly associated with cognitive impairment. Results Variables that were identified to be significantly associated with cognition, p < 0.05, were education level, disease duration, and family history. Discussion Both education level and disease duration were variables identified in previous studies. We showed family history to be a significant variable, and no association was found with depression or anxiety, which is unique to our study population. Conclusions We identified several psychosocial predictors that are associated with cognition in our patient population. It was also noted that a difference exists between patient populations, highlighting the need for further studies in specific geographical regions.

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Cognitive Impairment in Multiple Sclerosis

Cited by 35 publications

References 43 publications

Assessment and Impact of Cognitive Impairment in Multiple Sclerosis: An Overview

Assessment and Impact of Cognitive Impairment in Multiple Sclerosis: An Overview

Test-Retest Reliability of Cognitive-Motor Interference Assessments in Walking With Various Task Complexities in Persons With Multiple Sclerosis

The Relationship between Psychosocial Factors and Cognition in Multiple Sclerosis

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