Coherence between the sympathetic drives to relaxed and contracting muscles of different limbs of human subjects.

Wallin, B. Gunnar; Burke, David; Gandevia, Simon C.

doi:10.1113/jphysiol.1992.sp019298

Cited by 38 publications

(34 citation statements)

References 24 publications

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“…This is true at rest and during apnea (20,21). Thus microneurographic measurements reliably indicate the central drive to post-ganglionic sympathetic neurons to the vascular bed of skeletal muscle, which constitutes 45% of body mass and thus plays a key role in regulating arterial pressure (38).…”

Section: Resultsmentioning

confidence: 99%

Sympathetic neural mechanisms in obstructive sleep apnea.

Somers¹,

Dyken²,

Clary³

et al. 1995

J. Clin. Invest.

2,164

983

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Blood pressure, heart rate, sympathetic nerve activity, and polysomnography were recorded during wakefulness and sleep in 10 patients with obstructive sleep apnea. Measurements were also obtained after treatment with continuous positive airway pressure (CPAP) in four patients. Awake sympathetic activity was also measured in 10 age-and sexmatched control subjects and in 5 obese subjects without a history of sleep apnea.Patients with sleep apnea had high levels of nerve activity even when awake (P < 0.001). Blood pressure and sympathetic nerve activity did not fall during any stage of sleep. Mean blood pressure was 92±4.5 mmHg when awake and reached peak levels of 116±5 and 127±7 mmHg during stage II sleep (n = 10) and rapid eye movement (REM) sleep (n = 5), respectively (P < 0.001). Sympathetic activity increased during sleep (P = 0.01) especially during stage II (133+9% above wakefulness; P = 0.006) and REM (141±13%; P = 0.007). Peak sympathetic activity (measured over the last 10 s of each apneic event) increased to 299+96% during stage H sleep and to 246±36% during REM sleep (both P < 0.001). CPAP decreased sympathetic activity and blood pressure during sleep (P < 0.03).We conclude that patients with obstructive sleep apnea have high sympathetic activity when awake, with further increases in blood pressure and sympathetic activity during sleep. These increases are attenuated by treatment with CPAP. (J. Clin. Invest. 1995. 96:1897-1904 Key words: sympathetic nerve activity * blood pressure -hypertension hypoxia

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Section: Resultsmentioning

confidence: 99%

Sympathetic neural mechanisms in obstructive sleep apnea.

Somers¹,

Dyken²,

Clary³

et al. 1995

J. Clin. Invest.

2,164

983

View full text Add to dashboard Cite

show abstract

“…in human subjects. Wallin, Burke & Gandevia (1992) have recently shown that homologous muscles in humans are subject to a common sympathetic drive, resulting in high coherence values between simultaneous nerve recordings. There was also a significant difference between the ordinary coherence measured at the cardiac period and the correlation between the amplitudes of equivalent sympathetic bursts.…”

Section: Discussionmentioning

confidence: 99%

Baroreceptor influence on the relationships between discharges of different sympathetic nerves of the cat.

Kocsis¹

1995

The Journal of Physiology

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1. The sympathetic nerve discharge (SND) of three different nerves and the arterial blood pressure (BP) were recorded simultaneously in baroreceptor-intact cats. The linear correlation between different nerve pairs was characterized by the coherence spectrum and its baroreceptor-related component was estimated by partialization of the coherence on the basis of the blood pressure signal. 2. The SND-SND coherence values were higher than those found earlier in baroreceptordenervated cats. As shown by partial coherence analysis, in about 50 % of the experiments with high SND-BP coherence (25 nerve pair recordings), this could be explained by superposition of the effects of common central sources of activity and of the additional common rhythmic input from the baroreceptors. Partialization was ineffective in 50 % of the experiments with high SND-BP coherence (22 nerve pairs) and also when the SND-BP coherence was relatively low (17 nerve pairs). On the group average, after elimination of the components explained by baroreceptor influence, the peak SND-SND coherence no longer correlated with the SND-BP coherence and both the numerical values and the relative pattern of coherences between different nerves became similar to those characteristic for baroreceptor-denervated cats. 3. It is suggested that the method used in this study represents a 'theoretical barodenervation' and may be of great value in experiments, when surgical or chemical denervation of the baroreceptors does not represent a real option, e.g. in human subjects.

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“…Subjects attended three morning sessions, during which one of red wine, ethanol, or water was administered at random. To rest the fibular nerve between microneurographic recordings these sessions were scheduled at least 2 wk apart, and since muscle sympathetic nerve activity (MSNA) demonstrates between-leg congruence (33), alternate legs were studied on each session to minimize the potential for nerve trauma. Subjects were seated in a reclined chair, and an antecubital vein was canulated for blood sampling.…”

Section: Subjectsmentioning

confidence: 99%

Dose-related effects of red wine and alcohol on hemodynamics, sympathetic nerve activity, and arterial diameter

Spaak

Merlocco²,

Soleas³

et al. 2008

American Journal of Physiology-Heart and Circulatory Physiology

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The cardiovascular benefits of light to moderate red wine consumption often have been attributed to its polyphenol constituents. However, the acute dose-related hemodynamic, vasodilator, and sympathetic neural effects of ethanol and red wine have not been characterized and compared in the same individual. We sought to test the hypotheses that responses to one and two alcoholic drinks differ and that red wine with high polyphenol content elicits a greater effect than ethanol alone. Thirteen volunteers (24-47 yr; 7 men, 6 women) drank wine, ethanol, and water in a randomized, single-blind trial on three occasions 2 wk apart. One drink of wine and ethanol increased blood alcohol to 38 +/- 2 and 39 +/- 2 mg/dl, respectively, and two drinks to 72 +/- 4 and 83 +/- 3 mg/dl, respectively. Wine quadrupled plasma resveratrol (P < 0.001) and increased catechin (P < 0.03). No intervention affected blood pressure. One drink had no heart rate effect, but two drinks of wine increased heart rate by 5.7 +/- 1.6 beats/min; P < 0.001). Cardiac output fell 0.8 +/- 0.3 l/min after one drink of ethanol and wine (both P < 0.02) but increased after two drinks of ethanol (+0.8 +/- 0.3 l/min) and wine (+1.2 +/- 0.3 l/min) (P < 0.01). One alcoholic drink did not alter muscle sympathetic nerve activity (MSNA), while two drinks increased MSNA by 9-10 bursts/min (P < 0.001). Brachial artery diameter increased after both one and two alcoholic drinks (P < 0.001). No beverage augmented, and the second wine dose attenuated (P = 0.02), flow-mediated vasodilation. One drink of ethanol dilates the brachial artery without activating sympathetic outflow, whereas two drinks increase MSNA, heart rate, and cardiac output. These acute effects, which exhibit a narrow dose response, are not modified by red wine polyphenols.

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Coherence between the sympathetic drives to relaxed and contracting muscles of different limbs of human subjects.

Cited by 38 publications

References 24 publications

Sympathetic neural mechanisms in obstructive sleep apnea.

Sympathetic neural mechanisms in obstructive sleep apnea.

Baroreceptor influence on the relationships between discharges of different sympathetic nerves of the cat.

Dose-related effects of red wine and alcohol on hemodynamics, sympathetic nerve activity, and arterial diameter

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