2023
DOI: 10.1155/2023/3944457
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Cohort Profile: A Prospective Study of Gut Microbiota in Patients with Acute Ischemic Stroke

Abstract: Emerging evidence highlights the role in the gut microbiota (GM), integral parts of the gut-brain axis, and plays in developing various complications in patients with acute ischemic stroke (AIS). The link between the GM and disease can be actively utilized in the diagnosis of poststroke complications. AIS-GM cohort is a prospective study focusing on the link between gut microbial signature and adverse outcomes in patients with AIS. From September 2020 to July 2021, a total of 507 AIS patients were enrolled, th… Show more

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Cited by 6 publications
(6 citation statements)
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“…Accumulating evidence has increasingly recognized the gut microbiota as a crucial link between the gut and brain. Disturbances in the microbiota-gut-brain axis have been implicated in the pathophysiology of several psychiatric disorders, including SZ, with microbiota signatures being proposed as potential biomarkers [ 34 36 ]. Over the past decade, significant progress has been made in understanding the roles and mechanisms of the gut microbiota in psychiatric disorders.…”
Section: Discussionmentioning
confidence: 99%
“…Accumulating evidence has increasingly recognized the gut microbiota as a crucial link between the gut and brain. Disturbances in the microbiota-gut-brain axis have been implicated in the pathophysiology of several psychiatric disorders, including SZ, with microbiota signatures being proposed as potential biomarkers [ 34 36 ]. Over the past decade, significant progress has been made in understanding the roles and mechanisms of the gut microbiota in psychiatric disorders.…”
Section: Discussionmentioning
confidence: 99%
“…Strict regulatory approval and compliance are essential to ensure patient safety and treatment reliability. Formulating clear clinical trial protocols and regulatory policies will be a crucial task moving forward ( 103 , 104 ).…”
Section: Perspectives and Challengesmentioning
confidence: 99%
“…After the brain integrates the relevant external information and the body, it can act directly on the smooth muscle cells of the gastrointestinal tract, or transmit regulatory information to the neural plexus of the gastrointestinal tract along the autonomic nerve and neuroendocrine system, so as to perform the operation of the gut-brain axis ( Agirman et al., 2021 ; Mayer et al., 2022 ). Intestinal microbial flora imbalance has been implicated to the onset and progression of several neurological diseases, including PD, AD, multiple sclerosis, depression, and so on, according to an increasing number of studies ( Sun and Shen, 2018 ; Simpson et al., 2021 ; Chen et al., 2022 ; Xie et al., 2023 ). More research is also pointing to the pivotal function gut microbiota plays in CI.…”
Section: Gut Microbiome and Cerebral Infarctionmentioning
confidence: 99%