Cohort profile – MSK radiation workers: a feasibility study to establish a deceased worker sub-cohort as part of a multicenter medical radiation worker component in the million person study of low-dose radiation health effects

Dauer, Lawrence T.; Woods, Meghan; Miodownik, Daniel; Serencsits, Brian; Quinn, Brian; Bellamy, Michael; Yoder, Craig; Liang, Xiaolin; Boice, John D.; Bernstein, Jonine L.

doi:10.1080/09553002.2019.1587194

Cited by 7 publications

(4 citation statements)

References 28 publications

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“…Ongoing studies involving large pooled cohorts hold promise for improved information on lymphoma risks following radiation exposure. The Million Worker Study (MWS), coordinated by the National Council on Radiation Protection and Measurements, includes atomic weapons test veterans, US Department of Energy workers, nuclear power plant workers, industrial radiographers and medical radiation workers [169,170]. The MWS will provide unprecedented information on risks from protracted exposures, based on analysis of over 300 000 deaths.…”

Section: Discussionmentioning

confidence: 99%

Ionising radiation as a risk factor for lymphoma: a review

Harbron

Pasqual

2020

J. Radiol. Prot.

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The ability of ionising radiation to induce lymphoma is unclear. Here, we present a narrative review of epidemiological evidence of the risk of lymphoma, including chronic lymphocytic leukaemia (CLL) and multiple myeloma (MM), among various exposed populations including atomic bombing survivors, industrial and medical radiation workers, and individuals exposed for medical purposes. Overall, there is a suggestion of a positive dose-dependent association between radiation exposure and lymphoma. The magnitude of this association is highly imprecise, however, with wide confidence intervals frequently including zero risk. External comparisons tend to show similar incidence and mortality rates to the general population. Currently, there is insufficient information on the impact of age at exposure, high versus low linear energy transfer radiation, external versus internal or acute versus chronic exposures. Associations are stronger for males than females, and stronger for non-Hodgkin lymphoma and MM than for Hodgkin lymphoma, while the risk of radiation-induced CLL may be non-existent. This broad grouping of diverse diseases could potentially obscure stronger associations for certain subtypes, each with a different cell of origin. Additionally, the classification of malignancies as leukaemia or lymphoma may result in similar diseases being analysed separately, while distinct diseases are analysed in the same category. Uncertainty in cell of origin means the appropriate organ for dose response analysis is unclear. Further uncertainties arise from potential confounding or bias due to infectious causes and immunosuppression. The potential interaction between radiation and other risk factors is unknown. Combined, these uncertainties make lymphoma perhaps the most challenging malignancy to study in radiation epidemiology.

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Section: Discussionmentioning

confidence: 99%

Ionising radiation as a risk factor for lymphoma: a review

Harbron

Pasqual

2020

J. Radiol. Prot.

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“…As doses approach the levels typical of diagnostic x-ray examinations or occupational exposures (< ≈10 mGy), the required sample sizes become so large that national and multinational pooled cohorts are generally required (e.g. [28,58,59]). The HARMONIC project is the latest of such efforts, potentially involving a combined cohort size ten times larger than any previous epidemiological analysis of radiation risks in this patient group.…”

Section: Discussionmentioning

confidence: 99%

The HARMONIC project: Study design for assessment of cancer risks following cardiac fluoroscopy in childhood

et al. 2020

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The HARMONIC project (Health Effects of Cardiac Fluoroscopy and Modern Radiotherapy in Paediatrics) is a European study aiming to improve our understanding of the long-term health risks from radiation exposures in childhood and early adulthood. Here, we present the study design for the cardiac fluoroscopy component of HARMONIC. A pooled cohort of approximately 100 000 patients who underwent cardiac fluoroscopy procedures in Belgium,

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“…Quimby and Failla were among the first to demonstrate the direct relationship between the darkening of dental films and the degree of skin erythema in radiation workers and the importance for establishing full-scale wearable film badge programs in radiation treatment departments of hospitals to monitor occupational radiation exposure using dental X-ray films with filters distinguishing between gamma and beta radiation. 1,[25][26][27][28][29][30][31]…”

Section: Early Career: a Pioneer In Radiation Dosimetrymentioning

confidence: 99%