Cohort Profile: The Cebu Longitudinal Health and Nutrition Survey

Adair, Linda S.; Popkin, Barry M.; Akin, John S.; Guilkey, David K.; Gultiano, Socorro; Borja, Judith B.; Perez, Lorna; Kuzawa, Christopher W.; McDade, Thomas W.; Hindin, Michelle J.

doi:10.1093/ije/dyq085

Cited by 210 publications

(263 citation statements)

References 45 publications

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“…During the 2005 survey, 1,008 (62%) of the original cohort of 1,633 liveborn males were located and were willing to be interviewed, and 908 (56% of original cohort) men were located and enrolled in 2009. Subjects lost to attrition have generally been from higher socioeconomic status households (61), which is also true of the present sample (see below). Participants were compensated 100 pesos (w$2 US) for their time.…”

Section: Methodsmentioning

confidence: 77%

“…. Socioeconomic, demographic, and behavioral data were collected during in-home interviews administered by Cebuano-speaking interviewers (61). Men were classified as "partnered" if they identified themselves as married or in a cohabitating relationship (22).…”

Section: Discussionmentioning

confidence: 99%

“…Thus, the original sample was representative of births during that year. Subsequent attrition has largely been attributable to out-migration, and the refusal rate for the subjects in adult surveys has typically been w5% (61). During the 2005 survey, 1,008 (62%) of the original cohort of 1,633 liveborn males were located and were willing to be interviewed, and 908 (56% of original cohort) men were located and enrolled in 2009.…”

Section: Methodsmentioning

confidence: 99%

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Longitudinal evidence that fatherhood decreases testosterone in human males

Gettler

McDade

Feranil

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

435

381

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In species in which males care for young, testosterone (T) is often high during mating periods but then declines to allow for caregiving of resulting offspring. This model may apply to human males, but past human studies of T and fatherhood have been cross-sectional, making it unclear whether fatherhood suppresses T or if men with lower T are more likely to become fathers. Here, we use a large representative study in the Philippines (n = 624) to show that among single nonfathers at baseline (2005) (21.5 ± 0.3 y), men with high waking T were more likely to become partnered fathers by the time of follow-up 4.5 y later (P < 0.05). Men who became partnered fathers then experienced large declines in waking (median: −26%) and evening (median: −34%) T, which were significantly greater than declines in single nonfathers (P < 0.001). Consistent with the hypothesis that child interaction suppresses T, fathers reporting 3 h or more of daily childcare had lower T at follow-up compared with fathers not involved in care (P < 0.05). Using longitudinal data, these findings show that T and reproductive strategy have bidirectional relationships in human males, with high T predicting subsequent mating success but then declining rapidly after men become fathers. Our findings suggest that T mediates tradeoffs between mating and parenting in humans, as seen in other species in which fathers care for young. They also highlight one likely explanation for previously observed health disparities between partnered fathers and single men.challenge hypothesis | human evolution | hormones and behavior | paternal care | reproductive ecology I n male mammals, testosterone (T) stimulates the development and maintenance of traits and behaviors that contribute to male mating effort, including musculature, libido, conspecific aggressivity, and courtship (1-4). Although these T-driven traits factor into mating success, male reproductive fitness in some avian and mammalian species also depends on contributions to offspring care (5, 6). Because time and energy are finite (7), males in these species often face tradeoffs between conflicting behaviors related to mating and parenting. Adjustment of T production has been proposed as a physiological mechanism underlying this tradeoff, with males who focus on mating effort predicted to maintain elevated T, whereas males who cooperate with a female partner and invest in parental care should reduce T production (6,8). This model is well supported by data from a variety of avian species (6, 8), but evidence for its applicability to mammalian species in which males provide direct care is mixed (9). It is presently unclear whether T mediates the tradeoff between mating and parenting effort in human males, who often express paternal care facultatively.Humans have been described as serial monogamists who frequently engage in one or more long-lasting partnerships with females during reproductive life spans that last several decades (10-12). Humans are one of the few mammalian species in which paternal care is relati...

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Section: Methodsmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Longitudinal evidence that fatherhood decreases testosterone in human males

Gettler

McDade

Feranil

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

435

381

View full text Add to dashboard Cite

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“…The original study population, study design and recruitment protocols of the CLHNS have been described in detail previously (35). The CLHNS is a community-based birth cohort study which originally enrolled 3327 pregnant women in [1983][1984], and the women and their offspring have since been followed.…”

Section: Methodsmentioning

confidence: 99%

Genome-wide association study for adiponectin levels in Filipino women identifies CDH13 and a novel uncommon haplotype at KNG1–ADIPOQ

Wu¹,

Lange

et al. 2010

Human Molecular Genetics

116

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Adiponectin is an adipocyte-secreted protein involved in a variety of metabolic processes, including glucose regulation and fatty acid catabolism. We conducted a genome-wide association study to investigate the genetic loci associated with plasma adiponectin in 1776 unrelated Filipino women from the Cebu Longitudinal Health and Nutrition Survey (CLHNS). Our strongest signal for adiponectin mapped to the gene CDH13 (rs3865188, P ≤ 7.2 × 10−16), which encodes a receptor for high-molecular-weight forms of adiponectin. Strong association was also detected near the ADIPOQ gene (rs864265, P = 3.8 × 10−9) and at a novel signal 100 kb upstream near KNG1 (rs11924390, P = 7.6 × 10−7). All three signals were also observed in 1774 young adult CLHNS offspring and in combined analysis including all 3550 mothers and offspring samples (all P ≤ 1.6 × 10−9). An uncommon haplotype of rs11924390 and rs864265 (haplotype frequency = 0.050) was strongly associated with lower adiponectin compared with the most common C–G haplotype in both CLHNS mothers (P = 1.8 × 10−25) and offspring (P = 8.7 × 10−32). Comprehensive imputation of 2653 SNPs in a 2 Mb region using as reference combined CHB, JPT and CEU haplotypes from the 1000 Genomes Project revealed no variants that perfectly tagged this haplotype. Our findings provide the first genome-wide significant evidence of association with plasma adiponectin at the CDH13 locus and identify a novel uncommon KNG1–ADIPOQ haplotype strongly associated with adiponectin levels in Filipinos.

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“…When the CLHNS began collecting data in the early 1980s, Filipino families in Cebu lived in a wide range of settlements, including rural towns and remote outlying areas as well as dense urban areas with affluent neighborhoods and poorly constructed squatter camps (61). Approximately one-half of the homes in the study had electricity, more than three-quarters of families collected water from an open source, less than one-half of families used a flush toilet, and more than one-half of families had animals (e.g., dogs, chickens, goats, or pigs) roaming under, around, or in the house.…”

Section: Early Environments and The Eco-logics Of Inflammationmentioning

confidence: 99%

Early environments and the ecology of inflammation

McDade

2012

Proc. Natl. Acad. Sci. U.S.A.

185

154

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Recent research has implicated inflammatory processes in the pathophysiology of a wide range of chronic degenerative diseases, although inflammation has long been recognized as a critical line of defense against infectious disease. However, current scientific understandings of the links between chronic low-grade inflammation and diseases of aging are based primarily on research in high-income nations with low levels of infectious disease and high levels of overweight/obesity. From a comparative and historical point of view, this epidemiological situation is relatively unique, and it may not capture the full range of ecological variation necessary to understand the processes that shape the development of inflammatory phenotypes. The human immune system is characterized by substantial developmental plasticity, and a comparative, developmental, ecological framework is proposed to cast light on the complex associations among early environments, regulation of inflammation, and disease. Recent studies in the Philippines and lowland Ecuador reveal low levels of chronic inflammation, despite higher burdens of infectious disease, and point to nutritional and microbial exposures in infancy as important determinants of inflammation in adulthood. By shaping the regulation of inflammation, early environments moderate responses to inflammatory stimuli later in life, with implications for the association between inflammation and chronic diseases. Attention to the eco-logics of inflammation may point to promising directions for future research, enriching our understanding of this important physiological system and informing approaches to the prevention and treatment of disease.

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Cohort Profile: The Cebu Longitudinal Health and Nutrition Survey

Cited by 210 publications

References 45 publications

Longitudinal evidence that fatherhood decreases testosterone in human males

Longitudinal evidence that fatherhood decreases testosterone in human males

Genome-wide association study for adiponectin levels in Filipino women identifies CDH13 and a novel uncommon haplotype at KNG1–ADIPOQ

Early environments and the ecology of inflammation

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