Cohort Profile Update: The Isle of Wight Whole Population Birth Cohort (IOWBC)

Arshad, Syed Hasan; Patil, Veeresh; Mitchell, Frances; Potter, Stephen; Zhang, Hongmei; Ewart, Susan; Mansfield, Linda S.; Venter, Carina; Holloway, John W.; Karmaus, Wilfried

doi:10.1093/ije/dyaa068

Cited by 12 publications

(16 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The three generation Isle of Wight cohort study is the oldest prospective multi‐generation birth cohort with a focus on asthma, allergies and lung function. 45 It has confirmed previous reports of the effect of grand maternal smoking during pregnancy on grandchildren's risk of wheezing. 2 However, genome‐wide epigenotyping in parents and children did not confirm direct transfer of epigenetic markers.…”

Section: Transgenerational Inheritance Of Disease Susceptibilitysupporting

confidence: 87%

The role of epigenetics in multi‐generational transmission of asthma: An NIAID workshop report‐based narrative review

Wheatley

Holloway

Svanes

et al. 2022

Clin Experimental Allergy

Self Cite

View full text Add to dashboard Cite

There is mounting evidence that environmental exposures can result in effects on health that can be transmitted across generations, without the need for a direct exposure to the original factor, for example, the effect of grandparental smoking on grandchildren. Hence, an individual's health should be investigated with the knowledge of cross‐generational influences. Epigenetic factors are molecular factors or processes that regulate genome activity and may impact cross‐generational effects. Epigenetic transgenerational inheritance has been demonstrated in plants and animals, but the presence and extent of this process in humans are currently being investigated. Experimental data in animals support transmission of asthma risk across generations from a single exposure to the deleterious factor and suggest that the nature of this transmission is in part due to changes in DNA methylation, the most studied epigenetic process. The association of father's prepuberty exposure with offspring risk of asthma and lung function deficit may also be mediated by epigenetic processes. Multi‐generational birth cohorts are ideal to investigate the presence and impact of transfer of disease susceptibility across generations and underlying mechanisms. However, multi‐generational studies require recruitment and assessment of participants over several decades. Investigation of adult multi‐generation cohorts is less resource intensive but run the risk of recall bias. Statistical analysis is challenging given varying degrees of longitudinal and hierarchical data but path analyses, structural equation modelling and multilevel modelling can be employed, and directed networks addressing longitudinal effects deserve exploration as an effort to study causal pathways.

show abstract

Section: Transgenerational Inheritance Of Disease Susceptibilitysupporting

confidence: 87%

The role of epigenetics in multi‐generational transmission of asthma: An NIAID workshop report‐based narrative review

Wheatley

Holloway

Svanes

et al. 2022

Clin Experimental Allergy

Self Cite

View full text Add to dashboard Cite

show abstract

“…The IOWBC is a whole population‐based prospective study that recruited all children ( n = 1536, ~98% Caucasian) born between 1 January 1989 and 28 February 1990 on the Isle of Wight, UK, to study the natural history and aetiology of allergic and respiratory conditions 29,33 29,34 .…”

Section: Methodsmentioning

confidence: 99%

“…study the natural history and aetiology of allergic and respiratory conditions. 29,33 Parental informed consent was obtained to enrol 1456 newborns to participate in the ensuing follow-ups that occurred at the ages of 1, 2, 4, 10, 18 and 26 years, with >80% retention at all assessments up to 18 years and 71% retention at age 26 years. 29,34 In the current analysis, participants who had three or more valid eczema status information (i.e.…”

Section: Key Messagesmentioning

confidence: 99%

Sex‐specific developmental trajectories of eczema from infancy to age 26 years: A birth cohort study

Ziyab

Mukherjee

Zhang

et al. 2021

Clin Experimental Allergy

Self Cite

View full text Add to dashboard Cite

Background: Eczema is a common inflammatory skin disease with varying developmental trajectories/patterns that are influenced by different risk factors. The aim of this study was to investigate eczema development from infancy to early adulthood by identifying distinct developmental trajectories that describe disease patterns over time and evaluate the role of prenatal and early-life risk factors. Methods:The Isle of Wight Birth Cohort (n = 1456) was prospectively assessed at birth, 1, 2, 4, 10, 18 and 26 years. In all assessments, eczema was defined as chronic or chronically relapsing itchy dermatitis lasting >6 weeks with characteristic morphology and distribution in the past 12 months. Developmental trajectories of eczema between 1 or 2 and 26 years were identified separately for males and females by applying semiparametric mixture models. Associations were assessed by applying a modified Poisson regression to estimate adjusted risk ratios (aRR) and 95% confidence intervals (CI). Results:In both males and females, the following eczema developmental trajectories were identified: unaffected/transient (males: 77.7% vs. females: 73.0%), mid-onset late-resolving (males: 7.8% vs. females: 4.4%), late-onset (males: 5.2% vs. females: 9.5%) and early-onset persistent (males: 9.3% vs. females: 5.4%). In females, an additional trajectory was identified as follows: early-onset early-resolving (7.7%). Among males, filaggrin gene (FLG) variants (aRR = 2.45, 95% CI: 1.34-4.46) and paternal eczema (2.66, 1.39-5.08) were associated with the early-onset persistent trajectory.Among females, maternal eczema (2.84, 1.42-5.70) and high birthweight (2.25, 1.08-4.69) were associated with the early-onset persistent trajectory. Conclusions: Four and five trajectories represented eczema development among males and females, respectively, with different predisposing risk factors. Our results indicate that males and females may experience a different course of eczema.

show abstract

“…The F1 generation includes 1456 subjects from which 583 newborns remained for analysis after excluding those with missing values for maternal serum nicotine and its metabolites during pregnancy [ 17 ]. The F2 generation consists of 543 newborns from 331 mothers [ 18 ] of which 234 had biochemical data on nicotine metabolites in cord sera. Among these, data on DNAm at birth were available for 173 newborns.…”

Section: Methodsmentioning

confidence: 99%

“…Finally, we aimed to evaluate associations of maternal and cord sera nicotine, cotinine, norcotinine, and 3-hydroxycotinine with DNAm of the newborn (as early markers and potential mediators of health outcomes), focusing on 568 CpGs known to be associated with maternal smoking [ 16 ]. We used data from three generations of the Isle of Wight cohort: grandmothers (F0), mothers (F1), and F2-offspring [ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Nicotine and Its Downstream Metabolites in Maternal and Cord Sera: Biomarkers of Prenatal Smoking Exposure Associated with Offspring DNA Methylation

Rahimabad

Anthony

Jones

et al. 2020

IJERPH

Self Cite

View full text Add to dashboard Cite

Nicotine is a major constituent of cigarette smoke. Its primary metabolite in maternal and cord sera, cotinine, is considered a biomarker of prenatal smoking. Nicotine and cotinine half-lives are decreased in pregnancy due to their increased rate of metabolism and conversion to downstream metabolites such as norcotinine and 3-hydroxycotinine. Hence, downstream metabolites of nicotine may provide informative biomarkers of prenatal smoking. In this study of three generations (F0-mothers, F1-offspring who became mothers, and F2-offspring), we present a biochemical assessment of prenatal smoking exposure based on maternal and cord sera levels of nicotine, cotinine, norcotinine, and 3-hydroxycotinine. As potential markers of early effects of prenatal smoking, associations with differential DNA methylation (DNAm) in the F1- and F2-offspring were assessed. All metabolites in maternal and cord sera were associated with self-reported prenatal smoking, except for nicotine. We compared maternal self-report of smoking in pregnancy to biochemical evidence of prenatal smoking exposure. Self-report of F0-mothers of F1 in 1989–1990 had more accuracy identifying prenatal smoking related to maternal metabolites in maternal serum (sensitivity = 94.6%, specificity = 86.9%) compared to self-reports of F1-mothers of F2 (2010–2016) associated with cord serum markers (sensitivity = 66.7%, specificity = 78.8%). Nicotine levels in sera showed no significant association with any DNAm site previously linked to maternal smoking. Its downstream metabolites, however, were associated with DNAm sites located on the MYO1G, AHRR, and GFI1 genes. In conclusion, cotinine, norcotinine, and 3-hydroxycotinine in maternal and cord sera provide informative biomarkers and should be considered when assessing prenatal smoking. The observed association of offspring DNAm with metabolites, except for nicotine, may imply that the toxic effects of prenatal nicotine exposure are exerted by downstream metabolites, rather than nicotine. If differential DNA methylation on the MYO1G, AHRR, and GFI1 genes transmit adverse effects of prenatal nicotine exposure to the child, there is a need to investigate whether preventing changes in DNA methylation by reducing the metabolic rate of nicotine and conversion to harmful metabolites may protect exposed children.

show abstract

Cohort Profile Update: The Isle of Wight Whole Population Birth Cohort (IOWBC)

Cited by 12 publications

References 26 publications

The role of epigenetics in multi‐generational transmission of asthma: An NIAID workshop report‐based narrative review

The role of epigenetics in multi‐generational transmission of asthma: An NIAID workshop report‐based narrative review

Sex‐specific developmental trajectories of eczema from infancy to age 26 years: A birth cohort study

Nicotine and Its Downstream Metabolites in Maternal and Cord Sera: Biomarkers of Prenatal Smoking Exposure Associated with Offspring DNA Methylation

Contact Info

Product

Resources

About