Coital Urinary Incontinence Induced by Impairment of the Dorsal Nerve of the Clitoris in Rats

Cruz, Yolanda; Juárez, Raúl; Medel, Alfonso; Corona-Quintanilla, Dora Luz; Pacheco, Pablo; Juárez, Margarita

doi:10.1016/j.juro.2015.06.105

Cited by 12 publications

(7 citation statements)

References 30 publications

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“…Stretching nerve injury may also decrease microtubules and tau protein, important elements in axonal function (51). DNC and MBSP stretching due to VD may induce sexual and urinary dysfunction, since denervation of the clitoris induces signs of coital urinary incontinence (5) and damage of the EUS innervation induced signs of urinary incontinence in rats (6,29,42).…”

Section: 56)mentioning

confidence: 99%

Neuroanatomic and behavioral correlates of urinary dysfunction induced by vaginal distension in rats

Palacios-Galicia

Juárez

Morán

et al. 2016

American Journal of Physiology-Renal Physiology

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-The aim of the present study was to use a model of simulated human childbirth in rats to determine the damage to genitourinary structures and behavioral signs of urinary dysfunction induced by vaginal distension (VD) in female rats. In experiment 1, the length of the genitourinary tract and the nerves associated with it were measured immediately after simulated human delivery induced by VD or sham (SH) procedures. Electroneurograms of the dorsal nerve of the clitoris (DNC) were also recorded. In experiment 2, histological characteristics of the bladder and major pelvic ganglion of VD and SH rats were evaluated. In experiment 3, urinary parameters were determined in conscious animals during 6 h of dark and 6 h of light before and 3 days after VD or SH procedures. VD significantly increased distal vagina width (P Ͻ 0.001) and the length of the motor branch of the sacral plexus (P Ͻ 0.05), DNC (P Ͻ 0.05), and vesical nerves (P Ͻ 0.01) and decreased DNC frequency and amplitude of firing. VD occluded the pelvic urethra, inducing urinary retention, hematomas in the bladder, and thinness of the epithelial (P Ͻ 0.05) and detrusor (P Ͻ 0.01) layers of the bladder. Major pelvic ganglion parameters were not modified after VD. Rats dripped urine in unusual places to void, without the stereotyped behavior of micturition after VD. The neuroanatomic injuries after VD occur alongside behavioral signs of urinary incontinence as determined by a new behavioral tool for assessing micturition in conscious animals. external urethral sphincter; dorsal nerve of the clitoris; major pelvic ganglion; micturition MICTURITION consists of two phases: storage and urine expulsion. During storage, the detrusor is relaxed while the bladder neck and urethra are activated, preventing involuntary bladder emptying (11). Extrinsic elements such as the levator ani muscle also contribute to the maintenance of continence (3). When the bladder reaches its threshold volume, spinal and supraspinal reflexes are triggered to induce bladder contraction and urethral relaxation, and urine flows through the urethra (11). Damage to the lower urinary tract and/or its innervation can induce urinary dysfunction (3,29,41).Urinary dysfunction affects the health of many women (60). Stress urinary incontinence has been described as involuntary loss of urine during effort and is the most prevalent urinary disorder related to vaginal childbirth, which is known to injure the pudendal nerve and denervate the external urethral sphincter (EUS) (3, 15, 57).Maternal pelvic viscera and nerve damage results from the difficulty of human childbirth due the large fetal head and brain relative to the maternal pelvis size. Neonates at birth have heads that are close to the size of the maternal birth canal through which they must pass during the second stage of parturition (48). Births of fetuses over 4 kg or fetal malposition often prolong parturition (30), retaining the fetus in the pelvic cavity, the main anatomic resistance to fetal expulsion. Prolonged second stage of parturition...

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Section: 56)mentioning

confidence: 99%

Neuroanatomic and behavioral correlates of urinary dysfunction induced by vaginal distension in rats

Palacios-Galicia

Juárez

Morán

et al. 2016

American Journal of Physiology-Renal Physiology

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“…Mechanostimulation of the vagina, rectum, and perigenital skin induces contraction of the pubococcygeus, bulbospongiosus, ischiocavernosus, rhabdobsphincter, and external anal sphincter (EAS) . These viscero‐ and somato‐motor reflexes may be activated during normal pelvic functions such as micturition, defecation, copulation and parturition, and damage to the afferent or efferent reflex pathways are factors associated with urinary, fecal, or sexual dysfunctions …”

Section: Introductionmentioning

confidence: 99%

“…3 These viscero-and somato-motor reflexes may be activated during normal pelvic functions such as micturition, defecation, copulation and parturition, and damage to the afferent or efferent reflex pathways are factors associated with urinary, fecal, or sexual dysfunctions. 4,5 Innervation of pelvic and perineal regions arises from the lumbosacral spinal cord, and the nerve fibers reach their target travelling in the pelvic and pudendal (PDN) nerves. 3 These nerves may be damaged during pelvic surgeries and parturition, compromising pelvic functions.…”

Section: Introductionmentioning

confidence: 99%

Anatomical organization and somatic axonal components of the lumbosacral nerves in female rabbits

Cruz

Hernández-Plata

Lucio

et al. 2017

Neurourology and Urodynamics

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Most of the sacral spinal nerves of rabbit are mixed, carrying sensory, and motor information. Sacral nerves innervate the hind limbs, pelvic viscera, clitoris, perineal muscles, inguinal and anal glands and perineal, perigenital, and rump skin. The detailed description of the sacral nerves organization, topography, and axonal components further the knowledge of the innervation in pelvic and perinal structures of the female rabbit. This information will be useful in future studies about the physiology and physiopathology of urinary, fecal, reproductive, and sexual functions.

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“…En effet, en causant une faiblesse du plancher pelvien associée à une atteinte du nerf pudendal, ces neuropathies entrainaient une diminution de la pression de clôture urétrale, une hyperactivité détrusorienne et une altération du sphincter externe. Cruz et al (37) ont montré sur des rats ayant eu une dénervation bilatérale du nerf pudendal, que 67% des femelles expulsaient des urines après l'éjaculation du mâle.…”

Section: Discussionunclassified

L’incontinence coïtale

Moutounaïck

Miget

Teng

et al. 2018

Progrès en Urologie

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Coital Urinary Incontinence Induced by Impairment of the Dorsal Nerve of the Clitoris in Rats

Cited by 12 publications

References 30 publications

Neuroanatomic and behavioral correlates of urinary dysfunction induced by vaginal distension in rats

Neuroanatomic and behavioral correlates of urinary dysfunction induced by vaginal distension in rats

Anatomical organization and somatic axonal components of the lumbosacral nerves in female rabbits

L’incontinence coïtale

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