Coix lacryma-jobi chymotrypsin inhibitor displays antifungal activity

Ruan, Jingjun; Weng, Wenfeng; Yan, Jun; Zhou, Yuexia; Chen, Hui; Ren, Mingjian; Cheng, Jianping

doi:10.1016/j.pestbp.2019.06.016

Cited by 8 publications

(6 citation statements)

References 44 publications

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“…A novel chymotrypsin inhibitor (12.5 mg) from adlay seeds inhibited 89% of the proteases causing spore germination in six plant-pathogenic fungi, showing a typical sequence motif of seed-stored protehistinase inhibitors [ 118 ]. Adlay seed oil exhibited anti-bacterial activity against E. coli , S. aureus , and B. subtilis , with a minimum inhibitory concentration of 0.031 g/L and an MBC of 0.125 g/L of oil, which was effective for all tested bacteria [ 119 ].…”

Section: Action Pathway Against Disease Of Adlaymentioning

confidence: 99%

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Actional Mechanisms of Active Ingredients in Functional Food Adlay for Human Health

Zeng

Yang²,

Chen

et al. 2022

Molecules

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Medicinal and food homologous adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) plays an important role in natural products promoting human health. We demonstrated the systematic actional mechanism of functional ingredients in adlay to promote human health, based on the PubMed, CNKI, Google, and ISI Web of Science databases from 1988 to 2022. Adlay and its extracts are rich in 30 ingredients with more than 20 health effects based on human and animal or cell cultures: they are anti-cancer, anti-inflammation, anti-obesity, liver protective, anti-virus, gastroprotective, cardiovascular protective, anti-hypertension, heart disease preventive, melanogenesis inhibiting, anti-allergy, endocrine regulating, anti-diabetes, anti-cachexia, osteoporosis preventive, analgesic, neuroprotecting, suitable for the treatment of gout arthritis, life extending, anti-fungi, and detoxifying effects. Function components with anti-oxidants are rich in adlay. These results support the notion that adlay seeds may be one of the best functional foods and further reveal the action mechanism of six major functional ingredients (oils, polysaccharides, phenols, phytosterols, coixol, and resistant starch) for combating diseases. This review paper not only reveals the action mechanisms of adding adlay to the diet to overcome 17 human diseases, but also provides a scientific basis for the development of functional foods and drugs for the treatment of human diseases.

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Section: Action Pathway Against Disease Of Adlaymentioning

confidence: 99%

“…Anti-cancer [6,40,85,92], anti-inflammation [62], liver protection [101], preventive heart disease [69], melanogenesis inhibition [73], anti-cachexia [81], analgesic [6], extended life [118], anti-fungi [119] 9…”

Section: Oils and Triglyceridesmentioning

confidence: 99%

Actional Mechanisms of Active Ingredients in Functional Food Adlay for Human Health

Zeng

Yang²,

Chen

et al. 2022

Molecules

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“…Some naturally existing compounds in plants can inhibit proteolytic and amylolytic enzymes including trypsin, amylase, and chymotrypsin. Trypsin inhibitors can suppress growth by interfering with the digestion of protein, excessive production of pancreatic enzymes, pancreatic hypertrophy, and metabolic disruption in the use of sulfur amino acids in animals fed with plant products containing high concentrations of trypsin inhibitors 56 . In fermented plant foods, alpha-amylase inhibitor activity has scarcely been reported.…”

Section: Contamination Sources In Fermented Foodsmentioning

confidence: 99%

The importance and mitigation of mycotoxins and plant toxins in Southeast Asian fermented foods

et al. 2022

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Fermented foods (ffs) and beverages are widely consumed in Southeast Asia (SEA) for their nutritional balance, flavor, and food security. They serve as vehicles for beneficial microorganisms performing a significant role in human health. However, there are still major challenges concerning the safety of ffs and beverages due to the presence of natural toxins. In this review, the common toxins found in traditional ffs in SEA are discussed with special reference to mycotoxins and plant toxins. Also, mitigation measures for preventing risks associated with their consumption are outlined. Ochratoxin, citrinin, aflatoxins were reported to be major mycotoxins present in SEA ffs. In addition, soybean-based ff food products were more vulnerable to mycotoxin contaminations. Common plant toxins recorded in ffs include cyanogenic glycosides, oxalates, phytates and saponins. Combined management strategies such as pre-harvest, harvest and post-harvest control and decontamination, through the integration of different control methods such as the use of clean seeds, biological control methods, fermentation, appropriate packaging systems, and controlled processing conditions are needed for the safe consumption of indigenous ffs in SEA.

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“…Wild coix is a cross-pollinated perennial short-day plant. Under natural conditions, after inter-plant or intra-plant pollination in the wild population, the seeds mature, fall to the ground in autumn, and germinate into new plants in the following spring ( 22 ). Simultaneously, new tillers grow at the base of old stems and develop into fertile branches.…”

Section: The Origin and Germplasm Resources Of Adlaymentioning

confidence: 99%

“…Two of the proteins strongly inhibit the growth of T. viride , Poplar canker , and Fusarium graminearum , and they are chitosanases with a high degree of homology. Ruan et al ( 22 ) isolated an antifungal protein with significant activity against Mycosphaerella melonis , Helminthosporium turcicum , Alternaria solani , Phytophthora capsici , Isariopsis griseola , and Colletotrichum gloeosporioides from the coixs seeds by combining aqueous two-phase aqueous extraction, affinity chromatography, and centrifugal ultrafiltration.…”

Section: Bioactive Compounds and Health Benefits Of Adlaymentioning

confidence: 99%

Adlay, an ancient functional plant with nutritional quality, improves human health

Weng

Yan²,

Pan³

et al. 2022

Front. Nutr.

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Adlay (Coix lacryma-jobi L.), a crop closed related to maize (Zea mays L.) and sorghum (Sorghum bicolor L.), originated in tropical/subtropical regions of Asia and Africa; southwest China primary center of this plant’s origin, evolution and migration. Adlay is a traditional high-value minor crop used for both medicinal and dietary purposes. Adlay has anti-tumor, anti-bacterial, anti-inflammatory, analgesic, blood sugar-lowering, and blood lipid-lowering effects. To clarify the main bioactive components and phytochemical compounds and to fully explore their utility, this review summarizes the research done on the main functional ingredients of adlay, including amino acids and proteins, oils, vitamins and minerals, polysaccharides, and polyphenols. This study also highlighted the application of genome sequencing to tailor nutrient-rich adlay cultivars and nutraceutical product development. Additionally, the acquisition of high-density genomic data combined with next-generation phenotypic analysis will undoubtedly improve our understanding of the potential genetic regulation of adlay nutraceutical traits. This review provides new insights and ideas for the research of adlay in comparison and evolutionary genomics, and a useful reference for molecular breeding and genetic improvement of this important minor crop.

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Coix lacryma-jobi chymotrypsin inhibitor displays antifungal activity

Cited by 8 publications

References 44 publications

Actional Mechanisms of Active Ingredients in Functional Food Adlay for Human Health

Actional Mechanisms of Active Ingredients in Functional Food Adlay for Human Health

The importance and mitigation of mycotoxins and plant toxins in Southeast Asian fermented foods

Adlay, an ancient functional plant with nutritional quality, improves human health

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