COKE LIVe: recurrent vasculitis secondary to cocaine contaminated with levamisole

Abstract

Levamisole-induced vasculitis (LIV) is becoming an increasingly common entity secondary to both rising cocaine use in the UK and high levels of adulteration of cocaine with various contaminants. We report the first documented case of LIV secondary to adulterated cocaine in Ireland, which presented as a 6-year history of recurrent vasculitis of unknown aetiology. Classically, LIV is diagnosed by a combination of positive ANCA serology and agranulocytosis however, given the frequency of cocaine use, we urge acute physicians to consider the diagnosis in cases of typical retiform (angulated) purpura in association with a history of cocaine use.

Selective [3 + 2] cycloaddition reaction of isothiazol‐3(2h)‐ones with in situ formed azomethine ylide to thiazolidines and oxazolidines

“…Thiazolidine derivatives are extraordinarily important compounds found in natural products as bioactive molecules with promising antiproliferative, anthelmintic, and antimicrobial activities, such as Levamisole [36–43], Teneligliptin [44–46], RP66681 [47], and YM461 [48–50]. (Figure 1) These compounds have received increasing attention all over the world due to their medicinal value.…”

“…Thiazolidine derivatives are extraordinarily important compounds found in natural products as bioactive molecules with promising antiproliferative, anthelmintic, and antimicrobial activities, such as Levamisole [36][37][38][39][40][41][42][43], Teneligliptin [44][45][46], RP66681 [47], and YM461 [48][49][50].…”