COL1A1 (collagen, type I, alpha 1)

Mp, Simon; Maire, Georges; Pédeutour, Florence

doi:10.4267/2042/37719

Cited by 6 publications

(4 citation statements)

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“…COL1A1, located in chromosome 17, region 17q21–22, and presenting 51 exons, encodes the pro-α1 chain of type I collagen, which is consisting of a triple helix composed of one α2 chain and two α1 chains [ 36 ]. A fibrillar collagen C‑terminal domain (COLF) a collagen triple‑helix repeat and A von Willebrand factor type C (vWFC) domain are three conservative domains of COL1A1 [ 37 ]. Previous studies have shown that the expression of COL1A1 is correlated to a variety of tumor types, and COL1A1 is highly expressed in tumor tissues and cells [ 38 – 43 ].…”

Section: Discussionmentioning

confidence: 99%

Identification of COL1A1 associated with immune infiltration in brain lower grade glioma

Ren

2022

PLoS ONE

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Brain low grade gliomas (LGG) often give serious clinical symptoms due to the invasion towards nervous system, affecting the life quality of patients. Collagen type I alpha 1(COL1A1) is the main component of type I collagen. Although there are many reports about abnormal expression of COL1A1 in various tumors, specific role and clinical significance of COL1A1 in LGG have not yet been elucidated. In this work, Tumor Immune Estimation Resource database was used for detecting the expression level of COL1A1 in cancer and normal tissues, and aimed to explore the relationship between COL1A1 and tumor immune infiltration. We applied Kaplan-Meier to analyze the role of COL1A1 in clinical prognosis. Univariate survival rate and multivariate Cox analysis were used to compare clinical characteristics and survival rate. The relativity between the expression of COL1A1 and the tumor microenvironment was evaluated using ESTIMATE algorithm. Finally, the relationship between expression level of COL1A1 and gene marker sets of immune cell infiltration was investigated via TIMER. According to TCGA, COL1A1 overexpression was correlated with overall survival (OS), progression free interval (PFI) and disease specific survival (DSS) of multiple tumors, especially in LGG. Multivariate analysis showed that COL1A1 expression was an independent prognostic factor for LGG. The expression of COL1A1 was positively correlated with the infiltration of CD4 + T and CD8 + T cells, neutrophils, macrophages and dendritic cells in LGG. In addition, there was a strong correlation between expression of COL1A1 and different immune marker sets in LGG. The results suggest that COL1A1 is related with tumor immune infiltration of LGG.

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Section: Discussionmentioning

confidence: 99%

Identification of COL1A1 associated with immune infiltration in brain lower grade glioma

Ren

2022

PLoS ONE

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“…Collagen type I α 1 (COL1A1) encodes the pro-α 1 chains of type I collagen, which has a triple helix composed of two α 1 chains and one α 2 chain ( 2 ). COL1A1 contains three conservative domains, namely a von Willebrand factor type C (vWFC) domain, a collagen triple-helix repeat and a fibrillar collagen C-terminal domain (COLF) ( 3 ). It was recently found that COL1A1 is associated with a variety of tumor types, and that the expression of COL1A1 was high in tumor tissues and cells ( 4 – 14 ).…”

Section: Introductionmentioning

confidence: 99%

COL1A1 promotes metastasis in colorectal cancer by regulating the WNT/PCP pathway

et al. 2018

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Colorectal cancer (CRC) is the third leading cause of cancer-associated mortality, and is a major health problem. Collagen type I α 1 (COL1A1) is a major component of collagen type I. Recently, it was reported to be overexpressed in a variety of tumor tissues and cells. However, the function of COL1A1 in CRC remains unclear. Herein, the present study demonstrated that COL1A1 was upregulated in CRC tissues and the paired lymph node tissues. Transwell assays showed that COL1A1 promoted CRC cell migration in vitro. Moreover, it was revealed that COL1A1 levels were correlated with those of WNT/planar cell polarity (PCP) signaling pathway genes; inhibition of COL1A1 decreased the expression levels of Ras-related C3 botulinum toxin substrate 1-GTP, phosphorylated-c-Jun N-terminal kinase, and RhoA-GTP, all of which are key genes in the WNT/PCP signaling pathway. These results may indicate the mechanisms underlying the oncogenic role of COL1A1 in CRC. In summary, the present data indicated that COL1A1 may serve as an oncoprotein, and that it may be used as a potential therapeutic target in CRC.

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“…Type I collagen is a product of two genes. COL1A1, 1 which is located in chromosome 17, encodes pro α 1 (I) protein chain and COL1A2, 2 located in chromosome 7, encodes pro α 2 (I) chain. Its precursor form, type I procollagen, is synthesized by fibroblasts in soft tissues and by osteoblasts in bone tissue, and it contains aminoterminal and carboxyterminal propeptides.…”

Section: Introductionmentioning

confidence: 99%

Comparison of total and intact aminoterminal propeptide of type I procollagen assays in patients with breast cancer with or without bone metastases

et al. 2011

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COL1A1 (collagen, type I, alpha 1)

Abstract: This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 2.0 France Licence.

Cited by 6 publications

References 0 publications

Identification of COL1A1 associated with immune infiltration in brain lower grade glioma

Identification of COL1A1 associated with immune infiltration in brain lower grade glioma

COL1A1 promotes metastasis in colorectal cancer by regulating the WNT/PCP pathway

Comparison of total and intact aminoterminal propeptide of type I procollagen assays in patients with breast cancer with or without bone metastases

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