Colchicine for acute gout

McKenzie, Bayden J; Wechalekar, Mihir D.; Johnston, Renea V; Schlesinger, Naomi; Buchbinder, Rachelle

doi:10.1002/14651858.cd006190.pub3

Cited by 30 publications

(33 citation statements)

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“…Colchicine is a botanical alkaloid originally extracted from the seeds and bulbs of Colchicum autumnale L [ Colchicaceae ] ( McKenzie et al, 2021 ). The therapeutic effect of high-dose and low-dose oral colchicine on early acute gout attacks was reported by Robert A et al ( Terkeltaub et al, 2010 ) in a multicentre RCTs.…”

Section: Introductionmentioning

confidence: 99%

Safety Evaluation of Natural Drugs in Chronic Skeletal Disorders: A Literature Review of Clinical Trials in the Past 20 years

et al. 2022

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Chronic skeletal disorders (CSDs), including degenerative diseases such as osteoporosis (OP) and autoimmune disorders, have become a leading cause of disability in an ageing society, with natural drugs being indispensable therapeutic options. The clinical safety evaluation (CSE) of natural drugs in CSDs has been given priority and has been intensively studied. To provide fundamental evidence for the clinical application of natural drugs in the elderly population, clinical studies of natural drugs in CSDs included in this review were selected from CNKI, Web of Science, PubMed, Science Direct and Google Scholar since 2001. Seventeen randomized controlled trials (RCTs) met our inclusion criteria: four articles were on OP, seven on osteoarthritis (OA), four on rheumatoid arthritis (RA) and two on gout. Common natural drugs used for the treatment of OP include Epimedium brevicornu Maxim [Berberidaceae], Dipsacus asper Wall ex DC [Caprifoliaceae] root, and Phalaenopsis cornu-cervi (Breda) Blume & Rchb. f[ Orchidaceae], which have been linked to several mild adverse reactions, such as skin rash, gastric dysfunction, abnormal urine, constipation and irritability. The safety of Hedera helix L [Araliaceae] extract, Boswellia serrata Roxb [Burseraceae] extract and extract from perna canaliculus was evaluated in OA and upper abdominal pain, and unstable movements were obsrerved as major side effects. Adverse events, including pneumonia, vomiting, diarrhoea and upper respiratory tract infection, were reported when RA was treated with Tripterygium wilfordii, Hook. F [Celastraceae][TwHF] polyglycosides and quercetin (Capsella bursa-pastoris (L.) Medik [Brassicaceae]). The present review aimed to summarize the CSE results of natural drugs in CSDs and could provide evidence-based information for clinicians.

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Section: Introductionmentioning

confidence: 99%

Safety Evaluation of Natural Drugs in Chronic Skeletal Disorders: A Literature Review of Clinical Trials in the Past 20 years

et al. 2022

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“…3 The systematic review and meta-analysis summarized here identified four trials [4][5][6][7] (n = 803 participants) comparing colchicine with placebo, NSAIDs, or higher doses of colchicine. 8 The authors included randomized and quasi-randomized controlled trials of adults (age ≥ 18 years) with a diagnosis of acute gout. The primary outcome for the review was pain control (defined as the proportion of patients reporting ≥ 50% decrease in pain within the first 32-36 h of presentation).…”

Section: Narr Ativementioning

confidence: 99%

“…The primary outcome for the review was pain control (defined as the proportion of patients reporting ≥ 50% decrease in pain within the first 32-36 h of presentation). 8 Total adverse events and serious adverse events were also reported.…”

Section: Narr Ativementioning

confidence: 99%

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Colchicine for acute gout

Gottlieb

Rabah

Long

2021

Academic Emergency Medicine

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“…Colchicine is a classical anti-inflammation drug extracted from the autumn crocus and has been widely used in the treatment of gout [ 12 ]. Clinical trials have demonstrated that colchicine can inhibit atherosclerotic plaque rupture by reducing neutrophil aggregation [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Combination of Colchicine and Ticagrelor Inhibits Carrageenan-Induced Thrombi in Mice

Zhang

Huang

Yang

et al. 2022

Oxidative Medicine and Cellular Longevity

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The formation of a thrombus is closely related to oxidative stress and inflammation. Colchicine is one of the most commonly prescribed medication for gout treatment, with anti-inflammation and antioxidative stress properties. Therefore, we speculated that it is possible for colchicine to treat thrombosis. In this study, we used carrageenan to induce thrombosis in BALB/c mice and fed mice with colchicine, ticagrelor, and their combination, respectively. We found colchicine inhibited carrageenan-induced thrombi in mouse tail, and the inhibition was enhanced by ticagrelor. In vitro, colchicine inhibited thrombin-induced retraction of human platelet clots. Mechanically, colchicine inhibited platelet activation by reducing the expression of platelet receptors, protease-activated receptor 4 (PAR4) and CD36, and inactivating of AKT and ERK1/2 pathways. Furthermore, in human umbilical vein endothelial cells (HUVECs), colchicine showed antioxidative stress effects through increasing protein expression of glutathione peroxidase-1 (GPx-1), and mRNA levels of forkhead box O3 (FOXO3a) and superoxide dismutase 2 (SOD2). In RAW264.7 cells, colchicine reduced LPS-enhanced inflammatory response through attenuating toll-like receptor 4 (TLR4) activation. In addition, colchicine reduced LPS or ox-LDL-induced monocyte adhesion to HUVECs by inhibiting intercellular adhesion molecule-1 (ICAM-1) and vascular adhesion molecule-1 (VCAM-1) levels. Taken together, our study demonstrates that colchicine exerts antithrombotic function by attenuating platelet activation and inhibiting oxidative stress and inflammation. We also provide a potential new strategy for clinical treatment.

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Colchicine for acute gout

Cited by 30 publications

References 50 publications

Safety Evaluation of Natural Drugs in Chronic Skeletal Disorders: A Literature Review of Clinical Trials in the Past 20 years

Safety Evaluation of Natural Drugs in Chronic Skeletal Disorders: A Literature Review of Clinical Trials in the Past 20 years

Colchicine for acute gout

Combination of Colchicine and Ticagrelor Inhibits Carrageenan-Induced Thrombi in Mice

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