Cold Atmospheric Plasma (CAP) In Dentistry

Arora, Vipin

doi:10.4172/2161-1122.1000189

Cited by 58 publications

(58 citation statements)

References 50 publications

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“…CAP is an emerging technology that uses ionized gas to produce a plasma beam which has numerous applications in various fields, including dentistry, wound healing, surface decontamination, viral inhibition, and cancer treatment [11][12][13][14][15][16]. CAP can be used to treat the margins following tumor removal, and in doing so has the potential to remove residual cancer cells and prevent recurrence.…”

Section: Introductionmentioning

confidence: 99%

The Canady Helios Cold Plasma Scalpel Significantly Decreases Viability in Malignant Solid Tumor Cells in a Dose-Dependent Manner

Rowe¹,

Cheng²,

Ly³

et al. 2018

Plasma

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Abstract:To determine appropriate treatment doses of cold atmospheric plasma (CAP), the Canady Helios Cold Plasma Scalpel was tested across numerous cancer cell types including renal adenocarcinoma, colorectal carcinoma, pancreatic adenocarcinoma, ovarian adenocarcinoma, and esophageal adenocarcinoma. Various CAP doses were tested consisting of both high (3 L/min) and low (1 L/min) helium flow rates, several power settings, and a range of treatment times up to 5 min. The impact of cold plasma on the reduction of viability was consistently dose-dependent; however, the anti-cancer capability varied significantly between cell lines. While the lowest effective dose varied from cell line to cell line, in each case an 80-99% reduction in viability was achievable 48 h after CAP treatment. Therefore, it is critical to select the appropriate CAP dose necessary for treating a specific cancer cell type.

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Section: Introductionmentioning

confidence: 99%

The Canady Helios Cold Plasma Scalpel Significantly Decreases Viability in Malignant Solid Tumor Cells in a Dose-Dependent Manner

Rowe¹,

Cheng²,

Ly³

et al. 2018

Plasma

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“…Although heat treatments and antibiotics can also be used to eradicate the bacteria, they cause pain and increase risk of antibiotic resistance, respectively, and thus CAP represents a promising alternative. While CAP is used in treatment of root canals and dental caries, it has been noticed that plasma failed to completely eradicate bacterial cells hidden in the deeper layers of the biofilm [9]. Extracellular polymeric substances (EPS) produced by bacterial cell constitute the matrix of the bacterial biofilm, which holds bacterial communities together.…”

mentioning

confidence: 99%

Combination of Cold Atmospheric Plasma and Vitamin C Effectively Disrupts Bacterial Biofilms

Pandit¹,

Mokkapati²,

Helgadottir³

et al. 2017

Clin Microbiol

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Cold atmospheric plasma (CAP) is increasingly used in medical applications for eradication of bacterial and tumor cells. CAP treatment devices, known as plasma jet pens, produce reactive oxygen and nitrogen species at atmospheric pressure and room temperature. The produced reactive species are concentrated in a small and precisely defined area, allowing for high precision medical treatments. CAP has been demonstrated as very effective against planktonic bacterial cells. Unfortunately, bacterial cells in biofilms are typically aggregated and protected by dense exopolymeric matrix, synthesized and secreted by the bacterial community. The main limitation in using CAP against bacterial biofilms is the thick protective matrix of extracellular polymers that shields bacterial cells within this complex architecture. CAP has also been shown to effectively eradicate tumor cells, but the main current limitation is the susceptibility of the surrounding healthy tissues to higher doses. We have recently demonstrated that vitamin C, a natural food supplement, can be used to destabilize bacterial biofilms and render them more susceptible to the CAP killing treatment. Here we discuss the possible impact that a pre-treatment with vitamin C could have on CAP applications in medicine. Specifically, we argue that vitamin C could enhance the effectiveness of CAP treatments against both the bacterial biofilms and some selected tumors.

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“…Conservative dental treatment can sometimes be painful due to heat generation with drilling. In contrast, the temperature increase in the pulp of a tooth was found to be only ~2.3 o C during cold plasma treatment of the enamel surface, that does not cause discomfort to patients, because it does not induce thermal damage 17,18) . Given the aforementioned potential benefits of cold plasmas in oral application, it was thought that they might have a synergistic effect with bioglass paste on tooth remineralization.…”

Section: Introductionmentioning

confidence: 92%

Remineralizing effect of cold plasma and/or bioglass on demineralized enamel

El-Wassefy

2017

Dental Materials Journal

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This study investigated the combining effect of cold plasma and bioglass-phosphoric acid paste on demineralized enamel. Fifty bovine incisors' enamel specimens were challenged by a demineralization solution of pH 4.47 for 72 h. Specimens were divided into five groups: (I) Control, demineralized enamel (C); (II) Demineralized enamel treated with fluoride varnish (F); (III) Cold plasma application to demineralized enamel (P); (IV) Demineralized enamel treated with bioglass paste (B); (V) Application of bioglass paste to cold plasma-treated demineralized enamel (PB). Specimens were then immersed in remineralizing solution for 24 h, before being examined with micro-computed tomography (micro-CT), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS) and cross-sectional micro-hardness measurement. The results showed that; treating demineralized enamel with cold plasmas before bioglass application ensued a significant high mineral volume recovery and micro-hardness of demineralized region. It can be concluded that cold plasmas may improve the remineralization of bioglass on demineralized enamel.

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Cold Atmospheric Plasma (CAP) In Dentistry

Cited by 58 publications

References 50 publications

The Canady Helios Cold Plasma Scalpel Significantly Decreases Viability in Malignant Solid Tumor Cells in a Dose-Dependent Manner

The Canady Helios Cold Plasma Scalpel Significantly Decreases Viability in Malignant Solid Tumor Cells in a Dose-Dependent Manner

Combination of Cold Atmospheric Plasma and Vitamin C Effectively Disrupts Bacterial Biofilms

Remineralizing effect of cold plasma and/or bioglass on demineralized enamel

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