Cold atmospheric plasma therapy in wound healing

Dubey, Sunil Kumar; Parab, Shraddha; Alexander, Amit; Agrawal, Mukta; Achalla, Pavan Kumar; Pal, Udit Narayan; Pandey, Murali Monohar; Kesharwani, Prashant

doi:10.1016/j.procbio.2021.11.017

Cited by 70 publications

(25 citation statements)

References 72 publications

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“…Cold atmospheric plasma (CAP) therapy serves as a safe, rapid, non-invasive, and painless therapeutic approach for accelerating wound healing. The beneficial roles of CAP treatment for wound care include the generation of ROS and RNS for reducing bacterial burden, stimulation of faster migration of cells, and rapid wound healing with shortening of the inflammation phase in case of chronic wounds [ 341 ]. Cold plasma treatment holds great potential in the future for controlling and preventing infectious skin diseases in addition to the promotion of wound healing.…”

Section: Challenges and Future Prospectivementioning

confidence: 99%

Innovative Treatment Strategies to Accelerate Wound Healing: Trajectory and Recent Advancements

Kolimi

Narala

Nyavanandi

et al. 2022

Cells

179

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Wound healing is highly specialized dynamic multiple phase process for the repair of damaged/injured tissues through an intricate mechanism. Any failure in the normal wound healing process results in abnormal scar formation, and chronic state which is more susceptible to infections. Chronic wounds affect patients’ quality of life along with increased morbidity and mortality and are huge financial burden to healthcare systems worldwide, and thus requires specialized biomedical intensive treatment for its management. The clinical assessment and management of chronic wounds remains challenging despite the development of various therapeutic regimens owing to its painstakingly long-term treatment requirement and complex wound healing mechanism. Various conventional approaches such as cell therapy, gene therapy, growth factor delivery, wound dressings, and skin grafts etc., are being utilized for promoting wound healing in different types of wounds. However, all these abovementioned therapies are not satisfactory for all wound types, therefore, there is an urgent demand for the development of competitive therapies. Therefore, there is a pertinent requirement to develop newer and innovative treatment modalities for multipart therapeutic regimens for chronic wounds. Recent developments in advanced wound care technology includes nanotherapeutics, stem cells therapy, bioengineered skin grafts, and 3D bioprinting-based strategies for improving therapeutic outcomes with a focus on skin regeneration with minimal side effects. The main objective of this review is to provide an updated overview of progress in therapeutic options in chronic wounds healing and management over the years using next generation innovative approaches. Herein, we have discussed the skin function and anatomy, wounds and wound healing processes, followed by conventional treatment modalities for wound healing and skin regeneration. Furthermore, various emerging and innovative strategies for promoting quality wound healing such as nanotherapeutics, stem cells therapy, 3D bioprinted skin, extracellular matrix-based approaches, platelet-rich plasma-based approaches, and cold plasma treatment therapy have been discussed with their benefits and shortcomings. Finally, challenges of these innovative strategies are reviewed with a note on future prospects.

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Section: Challenges and Future Prospectivementioning

confidence: 99%

Innovative Treatment Strategies to Accelerate Wound Healing: Trajectory and Recent Advancements

Kolimi

Narala

Nyavanandi

et al. 2022

Cells

179

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“…Atmospheric pressure plasma jets (APPJs) are widely used in material surface treatment, plasma biomedical applications, and many other scientific and technological fields [1][2][3][4][5][6]. A very promising application area is the treatment of chronic wounds to improve their healing [7][8][9]. During the treatment of chronic wounds, the APPJs are not always perpendicular to the skin [10], and the relative permittivity of the wound may differ depending on the state of the damage and whether the injury is wet or dry [11], which introduces the complexity of the treatment.…”

Section: Introductionmentioning

confidence: 99%

Interaction of atmospheric pressure helium plasma jet with tilted dielectric target: split and deviation of ionization waves

Liu

Xia

Liu

et al. 2023

J. Phys. D: Appl. Phys.

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Atmospheric pressure plasma jets (APPJs) are commonly used plasma sources in many biomedical applications. Typically, the APPJs are not always perpendicular to the target to be treated. In this paper, the effects of tilted angle (α), relative permittivity (εr) of the target, the target potential, the distance (d) and the discharge parameters on the interaction of a helium APPJ with the target are investigated. Spatio-temporal resolved images show that the ionization wave (IW) split into a surface ionization wave (SIW) and a continued propagate IW when it approaches the target. The split leads to a position deviation of the IW interaction with the target. The measurements show that the split and deviation of IWs are strongly dependent on α and εr. For εr ≥ 9, the split can be only observed with α < 60°. The deviation gradually decreases as α increases from 15° to 90° with εr = 9. With the increase of εr from 9 to 56, the split and deviation are more pronounced with α = 30°. The deviation gradually increases as applied voltage and d values increase from 5.5 to 10.0 kV and 19 to 24 mm, respectively. However, the deviation is independent of the gas flow rate of 400 to 2000 standard cubic centimeters per minute. The split of IW depends on the combined effect of enhanced electric field due to target polarization and mismatch between the propagation direction of IW and the direction of enhanced electric field caused by α variation. An increase in εr results in a stronger dielectric polarization effect. Changes in α cause a misalignment between the propagation direction of IW and the direction of enhanced electric field. Additionally, decreasing α shortens the perpendicular distance (dsinα) between IW and the target surface, further enhancing the electric field in the perpendicular direction. After the split, there is an interaction between the SIW and the IW. The propagation of the SIW is restricted to the local electric field of IW.

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“…The impact of reactive oxygen and nitrogen species (RONS) on cell signaling, immunology, and tissue homeostasis has been thoroughly explored by C A Ferreira et al [5]. Due to the advantage of CAPs, any types of cold plasma devices have been developed and investigated, using measurement and modeling, for biomedical applications such as the DBD operated using air for skin treatment [6] for treated on the water surface produced plasma-activated water to apoptosis the cancer cell [7], the plasma jet with noble background gas [8], S K Dubey et al also reported the mechanism to speed the wound healing processes [9].…”

Section: Introductionmentioning

confidence: 99%

Modeling simulation of nitric oxide and ozone generated by the Compact Air Plasma Jet: Nightingale^®

Palee,

Thana,

Wijaikham

et al. 2023

J. Phys.: Conf. Ser.

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This study aimed to model and investigate the distribution characteristics of NO and O3 produced by a Compact Air Plasma Jet device using 0D and 2D fluid models. The 0D global model was employed to calculate densities in the plasma volume before constructing the 2D model for the distribution of densities via boundary conditions. As the feeding gas flow rate increased from 3 to 11 slm, the NO and O3 densities predicted by the 0D model decreased from 10 ppm to 1 ppm and from approximately 12 ppm to 1 ppm. In comparison with the gas detector measurements, the NO densities exhibited the same values and trends with respect to the number of pulses and flow rate, but O3 concentrations from the 0D model simulations were higher than those measured by the gas detector. With a 20 ms simulation time, NO concentrations decreased along the axial length, whereas O3 concentrations increased. Additionally, O3 concentrations from both models were higher than the measurements from the gas detector, which did not align with the experimental results. The incorporation of dominant humidity reaction sets improved the alignment between the modeling results and specific experimental observations. The model equipped with these additional humidity reaction sets can be effectively employed to predict the NO and O3 density generated by the Compact Air Plasma Jet device.

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Cold atmospheric plasma therapy in wound healing

Cited by 70 publications

References 72 publications

Innovative Treatment Strategies to Accelerate Wound Healing: Trajectory and Recent Advancements

Innovative Treatment Strategies to Accelerate Wound Healing: Trajectory and Recent Advancements

Interaction of atmospheric pressure helium plasma jet with tilted dielectric target: split and deviation of ionization waves

Modeling simulation of nitric oxide and ozone generated by the Compact Air Plasma Jet: Nightingale^®

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Cold atmospheric plasma therapy in wound healing

Cited by 70 publications

References 72 publications

Innovative Treatment Strategies to Accelerate Wound Healing: Trajectory and Recent Advancements

Innovative Treatment Strategies to Accelerate Wound Healing: Trajectory and Recent Advancements

Interaction of atmospheric pressure helium plasma jet with tilted dielectric target: split and deviation of ionization waves

Modeling simulation of nitric oxide and ozone generated by the Compact Air Plasma Jet: Nightingale®

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Product

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Modeling simulation of nitric oxide and ozone generated by the Compact Air Plasma Jet: Nightingale^®