Cold atmospheric pressure plasmas in dermatology: Sources, reactive agents, and therapeutic effects

Liu, Dawei; Zhang, Yanzhe; Xu, Maoyuan; Chen, Hongxiang; Lü, Xinpei; Ostrikov, Kostya

doi:10.1002/ppap.201900218

Cited by 77 publications

(42 citation statements)

References 186 publications

(310 reference statements)

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“…[ 63 ] We here report a subtle, but significant, change in morphology in some zebrafish larvae hatching from plasma‐treated eggs. This may point to sublethal alterations in embryonal development, which may not only be related to plasma‐derived ROS but also other plasma components present during direct treatment such as electric fields and UV radiation [ 64 ] that could potentially disrupt embryonic development. Nevertheless, the embryos exposed to direct plasma treatment had a mild reduction in the hatching rate and length‐to‐width‐ratio, and most of the hatched larvae survived at 5 dpf.…”

Section: Discussionmentioning

confidence: 99%

Zebrafish larvae as a toxicity model in plasma medicine

Gandhirajan

Endlich

Bekeschus

2020

Plasma Processes & Polymers

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Plasma technology has emerged as a promising tool in medicine that, however, requires not only efficacy but also toxicological assessments. Traditional cell culture systems are fast and economical, but they lack in vivo relevance; however, rodent models are highly complex and necessitate extended facilities. Zebrafish larvae bridge this gap, and many larvae can be analyzed in well plates in a single run, giving results in 1–2 days. Using the kINPen, we found plasma exposure to reduce hedging rates and viability in a dose‐dependent manner, accompanied with an increase in reactive oxygen species and a decrease of glutathione in plasma‐treated fish. Modest growth alterations were also observed. Altogether, zebrafish larvae constitute a fast, reliable, and relevant model for testing the toxicity of plasma sources.

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Section: Discussionmentioning

confidence: 99%

Zebrafish larvae as a toxicity model in plasma medicine

Gandhirajan

Endlich

Bekeschus

2020

Plasma Processes & Polymers

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“…The humid air promotes the production of OH and H 2 O 2 by the plasma. The air flow lead aerosols through the plasma, and the aerosol with high surface-volume ratio absorb the reactive plasma species including OH, H 2 O 2 , O 3 , NO 3 À and so on efficiently ( Figure 11) [66]. The interaction between aerosols and plasma also produce lots of charged aerosols.…”

Section: Biomedical Application Of Charged Aerosolsmentioning

confidence: 99%

“…The plasma plume appears continuous to naked eyes, is actually made up of fast propagating plasma bullet, which is proved by using the fast imaging technology. The plasma bullet travels at a velocity of 1.5 � 10 5 ms À 1 , higher than drift velocity of electrons 1.1 � 10 4 ms À 1 at the corresponding electric field [66][67][68]. The streamer propagation based on the photoionization theory is used to explain the plasma bullet propagation.…”

Section: Plasma Jetmentioning

confidence: 99%

On the charged aerosols generated by atmospheric pressure non‐equilibrium plasma

Zhang

et al. 2020

High Voltage

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Recently, charged aerosols are used widely in many applications, such as fog elimination, inactivation of airborne viruses and so on. Atmospheric pressure nonequilibrium plasma (APNP) have become an efficient way to generate charged aerosols. Except the traditional pin-plate or wire-plate APNP sources, the new APNP sources such as large scale corona discharge system and air plasma jet array are introduced. These sources can increase the ion density in open air and generate adjustable large plasma plume, which are helpful in increasing the charging efficiency on aerosols. Although the interactions between plasma and aerosols is quite complicated, the preliminary study suggests that the diffusion charging dominates aerosols below 0.1 μm, field charging dominates aerosols larger than 1 μm, and the photo charging also contributes to aerosols charging. These reactive charged aerosols have shown their potential in the artificial rain enhancement, biomedicine, and material processing. Finally, challenges and opportunities for theoretical, experimental, and application research in related cross-disciplinary areas are presented to stimulate critical discussions and collaborations in the future. Yanzhe Zhang and He Cheng contributed equally to this work. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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“…In recent years atmospheric pressure plasma jets (APPJs) produced in open environments have received a lot of attention, not only because of their versatility and ease of use, but also due to the encouraging results achieved in the most diverse applications [1][2][3][4][5]. Special attention has been given to medical and biological applications of APPJs, whose beneficial effects have been attributed to the reactive oxygen and nitrogen species (RONS) produced by the plasma jets [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Effects of O2 Addition on the Discharge Parameters and Production of Reactive Species of a Transferred Atmospheric Pressure Plasma Jet

2021

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The therapeutic effects of atmospheric pressure plasma jets (APPJs) have been associated with the presence of reactive species, mainly the reactive oxygen and nitrogen ones, generated in this kind of plasmas. Due to that, many studies attempting to enhance the production of reactive species in APPJs have been performed. The employment of gas admixtures, usually mixing a noble gas with oxygen (O2) or water vapor, is one of the most common methods to achieve such goal. This work presents a study of how the addition of small amounts of O2 affects the electrical parameters and the production of reactive species in a transferred APPJ produced at the tip of a long and flexible plastic tube. The study was carried out employing helium (He) as the working gas and applying a high voltage (HV) in the form of amplitude-modulated sine waveform (burst mode). With this configuration it was possible to verify that the O2 addition reduces the discharge power and effective current, as a result of late ignition and shorter discharge duration. It was also found that the addition of O2 to a certain content in the gas admixture makes the light emission from oxygen atoms increase, indicating an increment in oxygen related reactive species in the plasma jet. However, at the same time the light emitted from hydroxyl (OH) and nitric oxide (NO) exhibits the opposite behavior, i.e., decrease, indicating a reduction of such species in the APPJ. For these reasons, the addition of O2 to the working gas seems to be useful for increasing the effectiveness of the plasma treatment only when the target modification effect is directly dependent on the content of atomic oxygen.

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Cold atmospheric pressure plasmas in dermatology: Sources, reactive agents, and therapeutic effects

Cited by 77 publications

References 186 publications

Zebrafish larvae as a toxicity model in plasma medicine

Zebrafish larvae as a toxicity model in plasma medicine

On the charged aerosols generated by atmospheric pressure non‐equilibrium plasma

Effects of O2 Addition on the Discharge Parameters and Production of Reactive Species of a Transferred Atmospheric Pressure Plasma Jet

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