Cold plasma: a novel approach to treat infected dentin—a combined ex vivo and in vitro study

Pierdzioch, Philipp; Härtwig, Sven; Herbst, Sascha Rudolf; Raguse, Jan Dirk; Dommisch, Henrik; Abu-Sirhan, Shady; Wirtz, Henrik Carl; Hertel, Moritz; Paris, Sebastian; Preissner, Saskia

doi:10.1007/s00784-016-1723-5

Cited by 11 publications

(5 citation statements)

References 41 publications

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“…Another important field of kINPen application with high practical potential is in dentistry. Besides wound healing, the disinfection of tooth root canals and bones [40,328,380,381], the treatment of teeth or dental implants, mainly to remove biofilms [25,38,60,63,[382][383][384][385], or to improve cell spreading on tooth or implant surfaces [326,[386][387][388][389][390], the enhancement of the bond strength of orthodontic brackets [311], and the therapy of intraoral infections [385], are particularly promising fields of future application. kINPen treatment has also shown to increase the integration of implants in bone tissue [391].…”

Section: Plasma Medicinementioning

confidence: 99%

The kINPen—a review on physics and chemistry of the atmospheric pressure plasma jet and its applications

Reuter

Woedtke

Weltmann

2018

J. Phys. D: Appl. Phys.

411

355

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The kINPen ®4,5 plasma jet was developed from laboratory prototype to commercially available non-equilibrium cold plasma jet for various applications in materials research, surface treatment and medicine. It has proven to be a valuable plasma source for industry as well as research and commercial use in plasma medicine, leading to very successful therapeutic results and its certification as a medical device. This topical review presents the different kINPen plasma sources available. Diagnostic techniques applied to the kINPen are introduced. The review summarizes the extensive studies of the physics and plasma chemistry of the kINPen performed by research groups across the world, and closes with a brief overview of the main application fields.

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Section: Plasma Medicinementioning

confidence: 99%

The kINPen—a review on physics and chemistry of the atmospheric pressure plasma jet and its applications

Reuter

Woedtke

Weltmann

2018

J. Phys. D: Appl. Phys.

411

355

View full text Add to dashboard Cite

show abstract

“…The device is currently undergoing clinical trials [ 28 ]. Additionally, Pierdzioch et al [ 29 ] evaluated the effect of cold plasma on infected dentin both in vitro and ex vivo, demonstrating positive effects of plasma for the disinfection of dentin.…”

Section: Sources Of Ros In Dentistrymentioning

confidence: 99%

Generation and Role of Reactive Oxygen and Nitrogen Species Induced by Plasma, Lasers, Chemical Agents, and Other Systems in Dentistry

Jha

Ryu

Choi

et al. 2017

Oxidative Medicine and Cellular Longevity

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The generation of reactive oxygen and nitrogen species (RONS) has been found to occur during inflammatory procedures, during cell ischemia, and in various crucial developmental processes such as cell differentiation and along cell signaling pathways. The most common sources of intracellular RONS are the mitochondrial electron transport system, NADH oxidase, and cytochrome P450. In this review, we analyzed the extracellular and intracellular sources of reactive species, their cell signaling pathways, the mechanisms of action, and their positive and negative effects in the dental field. In dentistry, ROS can be found—in lasers, photosensitizers, bleaching agents, cold plasma, and even resin cements, all of which contribute to the generation and prevalence of ROS. Nonthermal plasma has been used as a source of ROS for biomedical applications and has the potential for use with dental stem cells as well. There are different types of dental stem cells, but their therapeutic use remains largely untapped, with the focus currently on only periodontal ligament stem cells. More research is necessary in this area, including studies about ROS mechanisms with dental cells, along with the utilization of reactive species in redox medicine. Such studies will help to provide successful treatment modalities for various diseases.

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“…Patients with triple-negative disease have a lower three-year survival rate following chemotherapy than patients with breast cancers of other subtypes [4]. Cold atmospheric plasma (CAP) has been extensively studied for its biomedical use in various fields such as surface decontamination [5], wound healing [6,7], dental treatment [8], allergen destruction [9], HIV virus treatment [10] and among others [11]. In particular, the research of CAP as a potential oncotherapeutic approach has thrived over the past decade and the mechanism is been increasingly understood [12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Treatment of Triple-Negative Breast Cancer Cells with the Canady Cold Plasma Conversion System: Preliminary Results

Cheng¹,

Rowe²,

Ly³

et al. 2018

Plasma

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Triple-negative breast cancer is a phenotype of breast cancer where the expression level of estrogen, progesterone and human epidermal growth factor receptor 2 (HER2) receptors are low or absent. It is more frequently diagnosed in younger and premenopausal women, among which African and Hispanic have a higher rate. Cold atmospheric plasma has revealed its promising ant-cancer capacity over the past two decades. In this study, we report the first cold plasma jet delivered by the Canady Cold Plasma Conversion Unit and characterization of its electric and thermal parameters. The unit effectively reduced the viability of triple-negative breast cancer up to 80% without thermal damage, providing a starting point for future clinical trials.

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Cold plasma: a novel approach to treat infected dentin—a combined ex vivo and in vitro study

Abstract: It was shown that the combination of cold plasma with CHX is the best available option for the disinfection of root surfaces.

Cited by 11 publications

References 41 publications

The kINPen—a review on physics and chemistry of the atmospheric pressure plasma jet and its applications

The kINPen—a review on physics and chemistry of the atmospheric pressure plasma jet and its applications

Generation and Role of Reactive Oxygen and Nitrogen Species Induced by Plasma, Lasers, Chemical Agents, and Other Systems in Dentistry

Treatment of Triple-Negative Breast Cancer Cells with the Canady Cold Plasma Conversion System: Preliminary Results

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