Collagen abnormalities in idiopathic adolescent scoliosis

Serum Somatomedin a and Non-Dialyzable Urinary Hydroxyproline in Girls with Idiopathic Scoliosis

“…Even if Nordwall (1973) was unable to find any difference in elastic stiffness of tendons or ligaments between scoliotics and controls, the experimental results of Francis et al (1977) suggest an abnormal cross-link formation and maturation in the collagen of patients with adolescent IS. They suggested that the finding could be related to the reported growth abnormality of these patients (Willner 1972, 1974, Nordwall & Willner 1975.…”

“…Scoliosis is frequently observed in association with connective tissue disorders (James 1970, Nordwall 1973, Nachemson & Sahlstrand 1977 and it has been suggested that patients with IS might have a generalized collagen disease (Francis et al 1977, Bushel1 et al 1978. Even if Nordwall (1973) was unable to find any difference in elastic stiffness of tendons or ligaments between scoliotics and controls, the experimental results of Francis et al (1977) suggest an abnormal cross-link formation and maturation in the collagen of patients with adolescent IS.…”

Collagen-Induced Platelet Aggregation and Bleeding Time in Adolescent Idiopathic Scoliosis

“…Also in idiopathic scoliosis collagen abnormalities are on record. Francis et al (1977) tested the resistance of extracted polymeric skin collagen against depolymerization by NaOH. This resistance was decreased in most patients with adolescent idiopathic scoliosis as compared with non-scoliotic controls.…”

Bleeding Time and Scoliosis

“…When a vessel wall is damaged platelets adhere to the exposed subendothelial collagen, and this contact initiates a chain of reactions resulting in the formation of a platelet thrombus (Gordon 1979). Collagen abnormalities have been described in idiopathic scoliosis (Francis et al 1977, Bushel1 et al 1978, UdCn et al 1980a. In adolescent idiopathic scoliosis the platelet aggregating power of collagen is decreased and the bleeding time prolonged (Udtn et al 1980a).…”