Collagen-Based Hydrogels for the Eye: A Comprehensive Review

Desai, Nimeet; Salave, Sagar; Karunakaran, Bharathi; Giri, Jyotsnendu; Benival, Derajram; Gorantla, Srividya; Kommineni, Nagavendra

doi:10.3390/gels9080643

Cited by 15 publications

(6 citation statements)

References 119 publications

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“…In particular, collagen is the major component of the corneal stroma: Collagen types I, III, V form a complex network that provides considerable mechanical strength, which is difficult to replicate in the laboratory using collagen extracted from natural sources. Collagen is currently exploited for a wide range of biomedical applications in ophthalmology too [55]. In particular, collagen-based hydrogels are known to improve cornea regeneration because of their capacity to favor cell migration and colonization.…”

Section: Biomaterials For Cornea Replacement and Restorationmentioning

confidence: 99%

Replace or Regenerate? Diverse Approaches to Biomaterials for Treating Corneal Lesions

Bonato,

Bagno

2024

Biomimetics

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The inner structures of the eye are protected by the cornea, which is a transparent membrane exposed to the external environment and subjected to the risk of lesions and diseases, sometimes resulting in impaired vision and blindness. Several eye pathologies can be treated with a keratoplasty, a surgical procedure aimed at replacing the cornea with tissues from human donors. Even though the success rate is high (up to 90% for the first graft in low-risk patients at 5-year follow-up), this approach is limited by the insufficient number of donors and several clinically relevant drawbacks. Alternatively, keratoprosthesis can be applied in an attempt to restore minimal functions of the cornea: For this reason, it is used only for high-risk patients. Recently, many biomaterials of both natural and synthetic origin have been developed as corneal substitutes to restore and replace diseased or injured corneas in low-risk patients. After illustrating the traditional clinical approaches, the present paper aims to review the most innovative solutions that have been recently proposed to regenerate the cornea, avoiding the use of donor tissues. Finally, innovative approaches to biological tissue 3D printing and xenotransplantation will be mentioned.

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Section: Biomaterials For Cornea Replacement and Restorationmentioning

confidence: 99%

Replace or Regenerate? Diverse Approaches to Biomaterials for Treating Corneal Lesions

Bonato,

Bagno

2024

Biomimetics

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“…Collagen-based hydrogel emerges as a promising candidate for corneal wound healing, aiding in epithelial organization, preventing hypertrophic changes, supporting differentiation, and facilitating cell delivery and transplantation [ 68 ]. Its applications support wound healing and provide protection to other ocular tissues.…”

Section: Current Clinical Management Of Corneal Scarringmentioning

confidence: 99%

Regenerative Therapy for Corneal Scarring Disorders

Chandran,

Santra,

Rubin

et al. 2024

Biomedicines

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The cornea is a transparent and vitally multifaceted component of the eye, playing a pivotal role in vision and ocular health. It has primary refractive and protective functions. Typical corneal dysfunctions include opacities and deformities that result from injuries, infections, or other medical conditions. These can significantly impair vision. The conventional challenges in managing corneal ailments include the limited regenerative capacity (except corneal epithelium), immune response after donor tissue transplantation, a risk of long-term graft rejection, and the global shortage of transplantable donor materials. This review delves into the intricate composition of the cornea, the landscape of corneal regeneration, and the multifaceted repercussions of scar-related pathologies. It will elucidate the etiology and types of dysfunctions, assess current treatments and their limitations, and explore the potential of regenerative therapy that has emerged in both in vivo and clinical trials. This review will shed light on existing gaps in corneal disorder management and discuss the feasibility and challenges of advancing regenerative therapies for corneal stromal scarring.

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“…In addition, materials like collagen, gelatin, and hyaluronic acid (HA) have also been explored . Collagen is a natural protein found abundantly in the extracellular matrix of various tissues, including bone . NFMS fabricated from collagen offers excellent biocompatibility and bioactivity .…”

Section: Designing Nfmsmentioning

confidence: 99%

Nanofibrous Microspheres: A Biomimetic Platform for Bone Tissue Regeneration

Desai,

Pande,

Vora

et al. 2024

ACS Appl. Bio Mater.

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Bone, a fundamental constituent of the human body, is a vital scaffold for support, protection, and locomotion, underscoring its pivotal role in maintaining skeletal integrity and overall functionality. However, factors such as trauma, disease, or aging can compromise bone structure, necessitating effective strategies for regeneration. Traditional approaches often lack biomimetic environments conducive to efficient tissue repair. Nanofibrous microspheres (NFMS) present a promising biomimetic platform for bone regeneration by mimicking the native extracellular matrix architecture. Through optimized fabrication techniques and the incorporation of active biomolecular components, NFMS can precisely replicate the nanostructure and biochemical cues essential for osteogenesis promotion. Furthermore, NFMS exhibit versatile properties, including tunable morphology, mechanical strength, and controlled release kinetics, augmenting their suitability for tailored bone tissue engineering applications. NFMS enhance cell recruitment, attachment, and proliferation, while promoting osteogenic differentiation and mineralization, thereby accelerating bone healing. This review highlights the pivotal role of NFMS in bone tissue engineering, elucidating their design principles and key attributes. By examining recent preclinical applications, we assess their current clinical status and discuss critical considerations for potential clinical translation. This review offers crucial insights for researchers at the intersection of biomaterials and tissue engineering, highlighting developments in this expanding field.

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Collagen-Based Hydrogels for the Eye: A Comprehensive Review

Cited by 15 publications

References 119 publications

Replace or Regenerate? Diverse Approaches to Biomaterials for Treating Corneal Lesions

Replace or Regenerate? Diverse Approaches to Biomaterials for Treating Corneal Lesions

Regenerative Therapy for Corneal Scarring Disorders

Nanofibrous Microspheres: A Biomimetic Platform for Bone Tissue Regeneration

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