Collagen/Chitosan Complexes: Preparation, Antioxidant Activity, Tyrosinase Inhibition Activity, and Melanin Synthesis

Vitiligo is an acquired disfiguring dermatosis characterized by patchy depigmentation due to the selective loss of functioning melanocytes. The incidence rate of vitiligo is approximately 0.5%-1.0% of the world's population. 1 At present, the aetiology of vitiligo remains unclear. Multiple studies demonstrated that massive oxidative stress may lead to vitiligo. Oxidation pathway is regarded as the important steps in the development of vitiligo. 2 In human skin, each melanocyte forms an epidermal melanin unit with 36 keratinocytes, which play an important role in maintaining melanocyte homeostasis. 3 Various growth factors produced by keratinocytes affect melanocyte proliferation and differentiation, such as endothelin-1, stem cell factor and basic fibroblast growth factor. 4-6 Additionally, keratinocyte-derived soluble factors regulate the melanogenesis of neighbouring melanocytes. 7 Moreover, various hormonal and peptide factors produced

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“…N refers to the number of melanocytes in the VLK group or the NHEK group. N C refers to the number of melanocytes in the control group 22 …”

Section: Methodsmentioning

confidence: 99%

Down‐regulation of exosomal miR‐200c derived from keratinocytes in vitiligo lesions suppresses melanogenesis

Zhao

Wang

et al. 2020

J Cellular Molecular Medi

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“…It has been found that ASC, salt soluble collagen, and pepsin-hydrolysed collagen showed both radical scavenger activity and ferric-reducing antioxidant power. Hua and collaborators [ 89 ] prepared a bioactive collagen/chitosan complex using fish skin collagen and chitosan solution as raw materials. The bioactive complex possessed antioxidant activity when tested in vivo in mice model, it reduced malonic dialdehyde content and increased SOD activity in mice serum [ 89 ].…”

Section: Fish Byproducts As Source Of High Added-value Compoundsmentioning

confidence: 99%

“…Hua and collaborators [ 89 ] prepared a bioactive collagen/chitosan complex using fish skin collagen and chitosan solution as raw materials. The bioactive complex possessed antioxidant activity when tested in vivo in mice model, it reduced malonic dialdehyde content and increased SOD activity in mice serum [ 89 ]. Moreover, collagen/gelatin/chitosan novel porous scaffolds fabricated using blends of collagen and gelatin obtained from the marine big eye snapper Priacanthus hamrur skin showed both antioxidant (maximum activity in both DPPH and ABTS assay at 1mg/mL) and antibacterial (maximum activity at 200 µg by disc diffusion assay) activity against E. coli and S. aureus [ 90 ].…”

Section: Fish Byproducts As Source Of High Added-value Compoundsmentioning

confidence: 99%

“… Wound healing Not specified [ 85 ] Collagen Scale Ctenopharyngodon idellus Wound healing Not specified [ 86 ] Collagen Skin Lophius litulon Antioxidant, wound healing 1–8 mg/mL4 g/day [ 87 ] Collagen Skin Oreochromis sp. Antioxidant 2–7 mg/mL [ 88 ] Collagen/chitosan Skin Not specified Antioxidant 12–100 μg/mL [ 89 ] Collagen/gelatin Skin Priacanthus hamrur Antioxidant, antibacterial DPPH and ABTS 1 mg/mL Antibacterial 200 μg [ 90 ] Collagen Swim bladders Nibea japonica Antioxidant 12.5–50μg/mL [ …”

Section: Fish Byproducts As Source Of High Added-value Compoundsmentioning

confidence: 99%

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Fish Waste: From Problem to Valuable Resource

et al. 2021

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Following the growth of the global population and the subsequent rapid increase in urbanization and industrialization, the fisheries and aquaculture production has seen a massive increase driven mainly by the development of fishing technologies. Accordingly, a remarkable increase in the amount of fish waste has been produced around the world; it has been estimated that about two-thirds of the total amount of fish is discarded as waste, creating huge economic and environmental concerns. For this reason, the disposal and recycling of these wastes has become a key issue to be resolved. With the growing attention of the circular economy, the exploitation of underused or discarded marine material can represent a sustainable strategy for the realization of a circular bioeconomy, with the production of materials with high added value. In this study, we underline the enormous role that fish waste can have in the socio-economic sector. This review presents the different compounds with high commercial value obtained by fish byproducts, including collagen, enzymes, and bioactive peptides, and lists their possible applications in different fields.

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“…An in vivo study on aged mice investigated the antioxidant action of chitosan, collagen, and the collagen/chitosan complex on superoxide dismutase and malonic dialdehyde. The test results showed that the collagen/chitosan complex had a greater ability to reduce the concentration of malonic dialdehyde and increase the activity of superoxide dismutase; in conclusion, when combining the two substances, a synergistic effect is obtained [ 88 ]. The same synergistic effect is obtained by linking chitosan with amino acids, which have their own free amino groups and thus increase the ability to clean free radicals [ 83 ].…”

Section: Properties Of Chitosan and Its Derivativesmentioning

confidence: 99%

New Opportunity to Formulate Intranasal Vaccines and Drug Delivery Systems Based on Chitosan

Popescu

Ghica

Dinu-Pîrvu

et al. 2020

IJMS

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In an attempt to develop drug delivery systems that bypass the blood–brain barrier (BBB) and prevent liver and intestinal degradation, it was concluded that nasal medication meets these criteria and can be used for drugs that have these drawbacks. The aim of this review is to present the influence of the properties of chitosan and its derivatives (mucoadhesion, permeability enhancement, surface tension, and zeta potential) on the development of suitable nasal drug delivery systems and on the nasal bioavailability of various active pharmaceutical ingredients. Interactions between chitosan and proteins, lipids, antigens, and other molecules lead to complexes that have their own applications or to changing characteristics of the substances involved in the bond (conformational changes, increased stability or solubility, etc.). Chitosan and its derivatives have their own actions (antibacterial, antifungal, immunostimulant, antioxidant, etc.) and can be used as such or in combination with other molecules from the same class to achieve a synergistic effect. The applicability of the properties is set out in the second part of the paper, where nasal formulations based on chitosan are described (vaccines, hydrogels, nanoparticles, nanostructured lipid carriers (NLC), powders, emulsions, etc.).

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Collagen/Chitosan Complexes: Preparation, Antioxidant Activity, Tyrosinase Inhibition Activity, and Melanin Synthesis

Cited by 42 publications

References 47 publications

Down‐regulation of exosomal miR‐200c derived from keratinocytes in vitiligo lesions suppresses melanogenesis

Down‐regulation of exosomal miR‐200c derived from keratinocytes in vitiligo lesions suppresses melanogenesis

Fish Waste: From Problem to Valuable Resource

New Opportunity to Formulate Intranasal Vaccines and Drug Delivery Systems Based on Chitosan

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