Collagen-derived matricryptins promote inhibitory nerve terminal formation in the developing neocortex

Su, Jianmin; Jiang, Chen; Lippold, Kumiko; Monavarfeshani, Aboozar; Carrillo, Gabriela L.; Jenkins, R; Fox, Michael A.

doi:10.1084/jem.2134oia29

Cited by 16 publications

(61 citation statements)

References 58 publications

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“…In Situ Hybridization. ISH was performed on 16-μm sections prepared as described previously (63,100). Slides were air dried for 30 min at room temperature and washed with PBS for 5 min to remove OTC.…”

Section: Methodsmentioning

confidence: 99%

“…At present, it is unclear how migrating thalamic GABAergic interneurons cross these CSPG-rich boundaries; however, neurotrophin or α3β1 integrin signaling are both sufficient to promote growth on inhibitory CSPGs in other brain regions (61,62). Cortical interneurons labeled in these Gad67-GFP mice are known to express neurotrophin receptors and α3β1 integrin (33,(63)(64)(65); therefore, it is possible that migratory thalamic GABAergic neurons also express these receptors.…”

Section: Thalamic Interneurons Migrate Through Growth Inhibitory Ecmmentioning

confidence: 99%

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Retinal inputs signal astrocytes to recruit interneurons into visual thalamus

Charalambakis

Sabbagh

et al. 2020

Proc. Natl. Acad. Sci. U.S.A.

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Inhibitory interneurons comprise a fraction of the total neurons in the visual thalamus but are essential for sharpening receptive field properties and improving contrast-gain of retinogeniculate transmission. During early development, these interneurons undergo long-range migration from germinal zones, a process regulated by the innervation of the visual thalamus by retinal ganglion cells. Here, using transcriptomic approaches, we identified a motogenic cue, fibroblast growth factor 15 (FGF15), whose expression in the visual thalamus is regulated by retinal input. Targeted deletion of functional FGF15 in mice led to a reduction in thalamic GABAergic interneurons similar to that observed in the absence of retinal input. This loss may be attributed, at least in part, to misrouting of interneurons into nonvisual thalamic nuclei. Unexpectedly, expression analysis revealed that FGF15 is generated by thalamic astrocytes and not retino-recipient neurons. Thus, these data show that retinal inputs signal through astrocytes to direct the long-range recruitment of interneurons into the visual thalamus.

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Section: Methodsmentioning

confidence: 99%

Section: Thalamic Interneurons Migrate Through Growth Inhibitory Ecmmentioning

confidence: 99%

Retinal inputs signal astrocytes to recruit interneurons into visual thalamus

Charalambakis

Sabbagh

et al. 2020

Proc. Natl. Acad. Sci. U.S.A.

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“…of ECM molecules, including collagens and glycoproteins are modified by proteases to yield novel matrikines, which are ECM molecule fragments that act as trophic and growth factors. Proteolytic modification of ECM molecules can also yield novel binding sites for integrins and other EM receptors called matricryptins (Ricard-Blum & Salza, 2014;Su, et al, 2016). If CD26 itself is not cleaving these ECM molecules directly it may be interacting with other proteases in regulating the creation of these molecules.…”

Section: Dpp4 Activitymentioning

confidence: 99%

What doesn't kill you makes you stranger: Dipeptidyl peptidase-4 (CD26) proteolysis differentially modulates the activity of many peptide hormones and cytokines generating novel cryptic bioactive ligands

Elmansi

Awad

Eisa

et al. 2019

Pharmacology & Therapeutics

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“…Taken together, the above observations suggest an essential function of Chodl at the neuromuscular junction. Interestingly, Chodl- (Zeng and Sanes, 2017) and Col19a1-expressing neurons also exist in the cortex, and Col19a1 mutant mice show synaptic defects (Su et al, 2016). This opens the perspective of more widespread roles of this ligand/receptor pair in synaptogenesis in other CNS regions.…”

Section: Chodl Acts Primarily In Synaptogenesismentioning

confidence: 91%