Collagen-modified chitosan microsphere as a novel hemoperfusion adsorbent for efficient removal of bilirubin from human plasma

Zhou, Wan; Zhang, Minjun; Liu, Xinjie; Hussain, Wajid; Zhu, Baoan; Yu, Huibin; Wang, Shenqi; Zhou, Lei

doi:10.1016/j.seppur.2024.126303

Cited by 8 publications

(2 citation statements)

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“…Hyperbilirubinemia can lead to jaundice, hepatitis, brain damage, and in severe cases, death. Meanwhile, other complications in patients have been clinically found to be accompanied by a massive accumulation of bilirubin in the human body [ 2 , 3 ]. How to quickly and effectively remove excess bilirubin from blood is an urgent issue that needs to be solved.…”

Section: Introductionmentioning

confidence: 99%

“…In the past few decades, various adsorbents, including activated carbons [ 7 ], polymer resins [ 8 ], natural polymers [ 2 ], inorganic mesoporous materials [ 5 ], etc., have been widely studied in hemoperfusion therapy to remove bilirubin. However, most of them have problems such as low adsorption performance, complex separation, high cost, and poor blood compatibility.…”

Section: Introductionmentioning

confidence: 99%

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Theory-Driven Tailoring of the Microenvironment of Quaternary Ammonium Binding Sites on Electrospun Nanofibers for Efficient Bilirubin Removal in Hemoperfusion

Fu,

Shi,

Chen

et al. 2024

Polymers

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Efficient adsorbents for excess bilirubin removal are extremely important for the treatment of hyperbilirubinemia. However, traditional adsorbents, such as activated carbons and ion-exchange resins, still suffer from dissatisfactory adsorption performance and poor blood compatibility. Herein, we adopted a rational design strategy guided by density functional theory (DFT) calculations to prepare blood-compatible quaternary ammonium group grafted electrospun polyacrylonitrile nanofiber adsorbents. The calculation analysis and adsorption experiments were used to investigate the structure–function relationship between group types and bilirubin adsorption, both indicating that quaternary ammonium groups with suitable configurations played a crucial role in bilirubin binding. The obtained nanofiber adsorbents showed the bilirubin removal efficiency above 90% even at a coexisting BSA concentration of 50 g L−1. The maximum adsorption capacities were 818.9 mg g−1 in free bilirubin solution and 163.7 mg g−1 in albumin bound bilirubin solution. The nanofiber adsorbents also showed considerable bilirubin removal in dynamic adsorption to reduce the bilirubin concentration to a normal level, which was better than commercial activated carbons. Our study demonstrates the high feasibility of a theory-driven design method for the development of grafted electrospun nanofibers, which have good potential as bilirubin adsorbents in hemoperfusion applications.

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Section: Introductionmentioning

confidence: 99%