Collagen Nerve Conduits and Processed Nerve Allografts for the Reconstruction of Digital Nerve Gaps: A Single-Institution Case Series and Review of the Literature

Rbia, Nadia; Bulstra, Liselotte F.; Saffari, Tiam M.; Hovius, Steven E.R.; Shin, Alexander Y.

doi:10.1016/j.wneu.2019.04.087

Cited by 40 publications

(48 citation statements)

References 31 publications

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“…Artificial nerve conduits have recently become used for peripheral nerve damage with a long nerve defect and damage of multiple peripheral nerves in which the nerve stumps cannot be directly sutured (1)(2)(3). However, there are several problems with artificial nerve conduits.…”

Section: Introductionmentioning

confidence: 99%

Influence of aging on the peripheral nerve repair process using an artificial nerve conduit

et al. 2020

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Section: Introductionmentioning

confidence: 99%

Influence of aging on the peripheral nerve repair process using an artificial nerve conduit

et al. 2020

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“…-Low grade of resistance to mechanical stress and weak manipulability (Schmidt et al, 2011). -Some scar neuroma cases in patients (Liodaki et al, 2013;Rbia et al, 2019).…”

Section: Collagenmentioning

confidence: 99%

“…There are few collagen nerve conduits approved by the Food and Drug Administration (FDA) and Conformity Europe (CE). NeuraGen ® , a nerve conduit made of type I bovine collagen derived from the Achilles tendon ( Di Summa et al, 2014 ), reported overlapped results compared to allograft 12 months post-surgery in patients with the reconstruction of a digital nerve gap inferior to 2.5 cm ( Rbia et al, 2019 ). However, some scar neuroma cases, with and without foreign bodies, imposed conduit removal ( Liodaki et al, 2013 ; Rbia et al, 2019 ).…”

Section: Natural-based Biomaterialsmentioning

confidence: 99%

“…NeuraGen ® , a nerve conduit made of type I bovine collagen derived from the Achilles tendon ( Di Summa et al, 2014 ), reported overlapped results compared to allograft 12 months post-surgery in patients with the reconstruction of a digital nerve gap inferior to 2.5 cm ( Rbia et al, 2019 ). However, some scar neuroma cases, with and without foreign bodies, imposed conduit removal ( Liodaki et al, 2013 ; Rbia et al, 2019 ). Maybe due to the tube high stiffness and high cost, it is not so popular among surgeons ( Arslantunali et al, 2014 ; Sedaghati et al, 2014 ).…”

Section: Natural-based Biomaterialsmentioning

confidence: 99%

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Natural-Based Biomaterials for Peripheral Nerve Injury Repair

Fornasari

Carta

Gambarotta

et al. 2020

Front. Bioeng. Biotechnol.

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Peripheral nerve injury treatment is a relevant problem because of nerve lesion high incidence and because of unsatisfactory regeneration after severe injuries, thus resulting in a reduced patient's life quality. To repair severe nerve injuries characterized by substance loss and to improve the regeneration outcome at both motor and sensory level, different strategies have been investigated. Although autograft remains the gold standard technique, a growing number of research articles concerning nerve conduit use has been reported in the last years. Nerve conduits aim to overcome autograft disadvantages, but they must satisfy some requirements to be suitable for nerve repair. A universal ideal conduit does not exist, since conduit properties have to be evaluated case by case; nevertheless, because of their high biocompatibility and biodegradability, natural-based biomaterials have great potentiality to be used to produce nerve guides. Although they share many characteristics with synthetic biomaterials, natural-based biomaterials should also be preferable because of their extraction sources; indeed, these biomaterials are obtained from different renewable sources or food waste, thus reducing environmental impact and enhancing sustainability in comparison to synthetic ones. This review reports the strengths and weaknesses of natural-based biomaterials used for manufacturing peripheral nerve conduits, analyzing the interactions between natural-based biomaterials and biological environment. Particular attention was paid to the description of the preclinical outcome of nerve regeneration in injury repaired with the different natural-based conduits.

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“…Although they lack cells, they typically maintain a highly organized extracellular matrix scaffold, which can induce axon regeneration. Acellular nerve allografts, also called processed nerve allografts, are now increasingly used instead of autografts [124,[127][128][129][130][131].…”

Section: Allograftsmentioning

confidence: 99%

Restoration of Neurological Function Following Peripheral Nerve Trauma

Kuffler

Foy

2020

IJMS

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Following peripheral nerve trauma that damages a length of the nerve, recovery of function is generally limited. This is because no material tested for bridging nerve gaps promotes good axon regeneration across the gap under conditions associated with common nerve traumas. While many materials have been tested, sensory nerve grafts remain the clinical “gold standard” technique. This is despite the significant limitations in the conditions under which they restore function. Thus, they induce reliable and good recovery only for patients < 25 years old, when gaps are <2 cm in length, and when repairs are performed <2–3 months post trauma. Repairs performed when these values are larger result in a precipitous decrease in neurological recovery. Further, when patients have more than one parameter larger than these values, there is normally no functional recovery. Clinically, there has been little progress in developing new techniques that increase the level of functional recovery following peripheral nerve injury. This paper examines the efficacies and limitations of sensory nerve grafts and various other techniques used to induce functional neurological recovery, and how these might be improved to induce more extensive functional recovery. It also discusses preliminary data from the clinical application of a novel technique that restores neurological function across long nerve gaps, when repairs are performed at long times post-trauma, and in older patients, even under all three of these conditions. Thus, it appears that function can be restored under conditions where sensory nerve grafts are not effective.

show abstract

Collagen Nerve Conduits and Processed Nerve Allografts for the Reconstruction of Digital Nerve Gaps: A Single-Institution Case Series and Review of the Literature

Cited by 40 publications

References 31 publications

Influence of aging on the peripheral nerve repair process using an artificial nerve conduit

Influence of aging on the peripheral nerve repair process using an artificial nerve conduit

Natural-Based Biomaterials for Peripheral Nerve Injury Repair

Restoration of Neurological Function Following Peripheral Nerve Trauma

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