Collagen particles with collagen-binding bone morphogenetic protein-2 promote vertebral laminar regeneration in infant rabbits

Cui, Yi; Bai, Xu; Yin, Yanyun; Chen, Bing; Zhao, Yannan; Xiao, Zhifeng; Yang, Bin; Shi, Yang; Fang, Yongxiang; Ma, Xu

doi:10.1088/1748-605x/ab9fce

Cited by 6 publications

(4 citation statements)

References 29 publications

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“…The integration of stem cells with BMP-2 to promote healthy bone regeneration has demonstrated great new bone formation, fast healing, and callus remodeling [2]. The therapeutic effect of collagen particles combined with BMP-2 with the collagen-binding domain has been shown to reconstruct vertebral laminar defects [38]. That being said, BMP-GFs have an osteoinductive potential for orthopedic clinical practice for the treatment of bone tissue regeneration.…”

Section: Growth Factors Roles In Bone Tissue Engineeringmentioning

confidence: 99%

Advances in Growth Factor Delivery for Bone Tissue Engineering

Oliveira

Nie

Podstawczyk

et al. 2021

IJMS

136

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Shortcomings related to the treatment of bone diseases and consequent tissue regeneration such as transplants have been addressed to some extent by tissue engineering and regenerative medicine. Tissue engineering has promoted structures that can simulate the extracellular matrix and are capable of guiding natural bone repair using signaling molecules to promote osteoinduction and angiogenesis essential in the formation of new bone tissues. Although recent studies on developing novel growth factor delivery systems for bone repair have attracted great attention, taking into account the complexity of the extracellular matrix, scaffolding and growth factors should not be explored independently. Consequently, systems that combine both concepts have great potential to promote the effectiveness of bone regeneration methods. In this review, recent developments in bone regeneration that simultaneously consider scaffolding and growth factors are covered in detail. The main emphasis in this overview is on delivery strategies that employ polymer-based scaffolds for spatiotemporal-controlled delivery of both single and multiple growth factors in bone-regeneration approaches. From clinical applications to creating alternative structural materials, bone tissue engineering has been advancing constantly, and it is relevant to regularly update related topics.

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Section: Growth Factors Roles In Bone Tissue Engineeringmentioning

confidence: 99%

Advances in Growth Factor Delivery for Bone Tissue Engineering

Oliveira

Nie

Podstawczyk

et al. 2021

IJMS

136

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“…At the same time, this temperature level causes normal tissue cells to synthesize certain proteins or release cytokines, such as HSP47, 72 HSP70, HSP90, 73–75 BMP2, BMP7, and so on. BMPs are considered a crucial pathway in osteoblast differentiation 76–78 . By adding some specific ions (like CO 3 2− ), the expression of MMP2 and MMP9 79 can also be increased, which can degrade the extracellular matrix and plays an important role in keratinocyte migration, granulation tissue remodeling, and angiogenesis.…”

Section: Biomedical Applications Of Temperature‐dependent Pttmentioning

confidence: 99%

“…BMPs are considered a crucial pathway in osteoblast differentiation. [76][77][78] By adding some specific ions (like CO 3 2− ), the expression of MMP2 and MMP9 79 can also be increased, which can degrade the extracellular matrix and plays an important role in keratinocyte migration, granulation tissue remodeling, and angiogenesis.…”

Section: The Temperature Of 40-42°c For Tissue Regenerationmentioning

confidence: 99%

Biomedical applications and prospects of temperature‐orchestrated photothermal therapy

Zhang

et al. 2022

MedComm – Biomaterials and Applications

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Photothermal therapy (PTT) has been regarded as a promising strategy considering its advantages of high inherent specificity and a lower invasive burden. Since the photothermal killing of cells/bacteria showed different patterns of death depending on the varying temperature in PTT, the temperature change of PTT is vital to cell/tissue response in scientific research and clinical application. On one hand, mild PTT has received substantial attention in the treatment of cancer and soft/hard tissue repair. On the other hand, the high temperature induced by PTT is capable of antibacterial capacity, which is better than conventional antibiotic therapy with drug resistance. Herein, we summarize the recent developments in the application of temperature-dependent photothermal biomaterials, mainly covering the temperature ranges of 40-42°C, 43-50°C, and over 50°C. We highlight the biological mechanism of PTT and the latest progress in the treatment of different diseases. Finally, we conclude by discussing the challenges and perspectives of biomaterials in addressing temperatureorchestrated PTT. Given a deep understanding of the interaction between temperature and biology, rationally designed biomaterials with sophisticated photothermal responsiveness will benefit the outcomes of personalized PTT toward various diseases.

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“…Collagen is the main component of the extracellular matrix, and has received continuous attention in biomedical and tissue engineering fields due to its advantages of excellent biocompatibility, biodegradation and low immunogenicity [1][2][3]. Normally, highly ordered collagen fibers are present in vivo and provide the soft tissue of biological organisms with various tissue-specific functions such as elasticity, resilience and other mechanical properties [4].…”

Section: Introductionmentioning

confidence: 99%

Electro-deposition synthesis of tube-like collagen–chitosan hydrogels and their biological performance

Li¹,

He²,

Li³

et al. 2021

Biomed. Mater.

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Electro-deposition is a smart, safe and efficient method for biomaterial manufacturing. Collagen, a functional protein with excellent biocompatibility and biosafety, is a promising candidate for tissue engineering and biomedical applications. However, there are few reports on electro-deposition of biomaterials using collagen without electrically or magnetically active nanoparticles. In this study, electro-deposition was employed to swiftly fabricate tube-like collagen–chitosan hydrogels in a mild environment. Fourier transform infrared spectroscopy was employed to analyze the ingredients of the tube-like hydrogels. The result showed that the hydrogels contained both collagen and chitosan. The distribution and content of collagen in the hydrogels was further measured by hematoxylin–eosin staining and hydroxyproline titration. Collagen was distributed homogeneously and its content was related to the initial collagen:chitosan ratio. The tension resistance of the composite gels and the thermal stability of collagen in the composites were obviously enhanced by the chitosan doping. Meanwhile, the tube-like hydrogels retained a good ability to promote cell proliferation of collagen. This method offers a convenient approach to the design and fabrication of collagen-based materials, which could effectively retain the bioactivity and biosafety of collagen and furnish a new way to enhance the stability of collagen and the tensile strength of collagen-based materials.

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Collagen particles with collagen-binding bone morphogenetic protein-2 promote vertebral laminar regeneration in infant rabbits

Cited by 6 publications

References 29 publications

Advances in Growth Factor Delivery for Bone Tissue Engineering

Advances in Growth Factor Delivery for Bone Tissue Engineering

Biomedical applications and prospects of temperature‐orchestrated photothermal therapy

Electro-deposition synthesis of tube-like collagen–chitosan hydrogels and their biological performance

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