Collagenase Versus Placebo in the Treatment of Peyronie’s Disease: A Double-blind Study

Gelbard, Martin K.; James, Kathleen; Riach, Pamela; Dorey, Frederick J.

doi:10.1016/s0022-5347(17)35998-0

Cited by 197 publications

(135 citation statements)

References 5 publications

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“…27 In this study of 49 men, a statistically significant improvement in plaque size was found following collagenase treatment as compared to placebo control. The patients were stratified according to the severity of their disease and a modified Kelami system was used for classification.…”

Section: Intralesional Therapymentioning

confidence: 60%

Review of current nonsurgical management of Peyronie's disease

Levine

2003

Int J Impot Res

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The current nonsurgical treatment options for men with Peyronie's disease is reviewed. The treatments currently employed and published in the English literature are discussed. A wide variety of nonsurgical treatment options are available to the practicing physician, including oral and topical medications, intralesional injection therapy, as well as employing external energy sources to drive medicine into the tunica albuginea by iontophoresis or direct stimulation of plaque change by shock wave therapy. Nonsurgical treatment of Peyronie's disease clearly has a place in the armamentarium of the practicing urologist. Oral therapy appears to have little therapeutic benefit. Injection and topical approaches deserve further attention. Yet, no single treatment stands out as the most effective remedy for all men with Peyronie's disease. Further controlled, large-scale studies are necessary to establish the benefits of these nonsurgical approaches. In the meantime, combination therapy appears to make sense in the nonsurgical treatment of men with Peyronie's disease.

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Section: Intralesional Therapymentioning

confidence: 60%

Review of current nonsurgical management of Peyronie's disease

Levine

2003

Int J Impot Res

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“…46 Initial trials of intra-plaque injection with collagenase have been disappointing. 47 Intralesional injection of either alpha 2A or alpha 2B interferon have also been reported with mixed results. 48,49 Oral tamoxifen has been tested as a therapeutic agent to treat Peyronie's disease.…”

Section: Molecular Mechanisms: Oxidative Damage and The Role Of Free mentioning

confidence: 99%

Pathophysiology of Peyronie's disease

Moreland

Nehra

2002

Int J Impot Res

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“…Adverse events occurred in 20 (80%) patients, with edema, penile pain and ecchymosis as the most common. A double-blind, placebocontrolled trial by Gelbard et al 59 in 1993, composed of 49 men, showed a statistically significant improvement in vacuum-induced curvature in the treatment group when compared with placebo; however, maximal improvement ranged from 151 to 201 and was only seen in the patients with curvature of less than 301 and plaques of less than 2 cm in length. Currently, this agent is in a large scale, multicenter, multination, randomized, placebo-controlled trial, 60 which may become the first FDA-approved treatment for PD.…”

Section: Collagenasementioning

confidence: 99%