Collagenous Gastritis

Abstract

This report reviews the literature pertaining to collagenous gastritis and describes the clinicopathologic evolution of this disease in a patient during a 12-year period. We examined 109 biopsy specimens of gastric mucosa from 19 different endoscopic procedures for the severity and distribution of collagenous gastritis in a single patient. Assessments were undertaken for the presence of endocrine and gastrin cell hyperplasias and dysplastic epithelial changes. Relative to biopsy specimens from age- and sex-matched control subjects, the patient's biopsy specimens showed a significantly lower number of antral gastrin cells, along with a significant corpus endocrine cell hyperplasia, suggesting an increased risk of endocrine neoplasia. Gastric corpus biopsy specimens revealed an active, chronic gastritis, subepithelial collagen deposition, smooth muscle hyperplasia, and mild to moderate glandular atrophy. Additional findings of intestinal metaplasia and reactive epithelial changes indeterminate for dysplasia raise concerns about the potential for adenocarcinoma.

Collagenous Gastritis in Children: Incidence, Disease Course, and Associations With Autoimmunity and Inflammatory Markers

“…The current literature on childhood-onset CG consists mainly of case reports ( 15 – 20 , 27 – 37 , 42 , 43 , 51 ), apart from 6 small case series ( 21 , 22 , 38 – 41 ) and 3 histopathologic studies with limited clinical information and follow-up data ( 23 , 24 , 45 ). Consequently, the knowledge regarding the evolution of the clinical, endoscopic, and histologic features of the disease over time is sparse.…”

Collagenous Gastritis, a Rare Cause of Dyspepsia Resistant to Treatment; A Case Report

“…Colletti and colleagues firstly discovered this condition in a 15-year-old girl in 1989. 5,6 The patient was suffering from recurrent abdominal pain and gastrointestinal bleeding.…”

Collagenous Gastritis a Rare Disorder in Search of a Disease

“…Winslow et al performed a continuous 24-hour gastric pH monitoring. It demonstrated a pH less than 2 and appropriate inhibition by ranitidine (namely, pH > 4, 45% of the time) [ 15 ]. It implies that patients with collagenous gastritis do not have achlorhydria as seen in atrophic gastritis.…”

“…Winslow et al describes the clinicopathologic evolution of collagenous gastritis in a single patient during a 12-year period [ 15 ]. A hundred and nine gastric biopsy specimens from 19 different endoscopic procedures were evaluated for severity and distribution of collagenous gastritis in this patient.…”