Given the growing global emphasis on sustainable transportation systems, this research presents a comprehensive approach to achieving economic, social, and environmental efficiency in transport within the waste management sector. To address the different challenges of sustainable transportation issues, this paper presents a hybrid multi-criteria decision-making (MCDM) approach that incorporates the analytic hierarchy process (AHP) along with data envelopment analysis (DEA) for sustainable route selection. By leveraging the strengths of both methods, this approach reconciles conflicting requirements and diverse perspectives, facilitating effective decision making. This paper involves identifying relevant criteria for route evaluation, engaging waste management company experts and stakeholders in pairwise comparisons using AHP. Furthermore, DEA is used to calculate route efficiency based on the inputs and outputs of the system. These evaluations enable the identification of the most effective and sustainable routes. This proposed methodology empowers decision makers and transportation policymakers to develop an effective decision-making tool for addressing waste transportation challenges in developing countries. The study contributes to the growing body of research on sustainable waste management practices and provides insights for waste management companies and decision makers on how to optimize waste transportation routes while reducing economic, social, and environmental impacts.