Collective cell migration: guidance principles and hierarchies

Haeger, Anna; Wolf, Katarina; Zegers, Mirjam M.; Friedl, Peter

doi:10.1016/j.tcb.2015.06.003

Cited by 383 publications

(361 citation statements)

References 142 publications

(212 reference statements)

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“…growth, migration, invasion and angiogenesis (23,24). As acknowledged, cell migration and invasion serve pivotal roles in angiogenesis, tissue repair and immune response, which are all deregulated in cancer cells (25,26). In the present study, the influence of miR-766-5p inhibitor on SW480 cell proliferation, apoptosis, migration and invasion was investigated.…”

Section: Discussionmentioning

confidence: 90%

The role of miR-766-5p in cell migration and invasion in colorectal cancer

2018

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Abstract. Colorectal cancer (CRC) develops from the colon or rectum and is the fourth highest inducer of cancer mortality. In the present study, cancer tissues and normal tissues were extracted from patients with CRC who were treated in the Affiliated Hospital of Shandong University of Traditional Chinese Medicine (Jinan, China). Reverse transcription-quantitative polymerase chain reaction demonstrated that the expression level of miR-766-5p was significantly higher (P<0.01) in cancer tissue than that in normal tissue. SW480 cells were used for in vitro study and randomly separated into the miR-negative control (NC) inhibitor treatment group and miR-766-5p inhibitor treatment group. SW480 cell behaviors were evaluated. Results demonstrated that in the miR-766-5p inhibitor group, there was a decreased level of cell proliferation/migration/invasion and higher cell apoptosis compared with that in the miR-NC inhibitor group. miR-766-5p was predicted and verified to target the 3' untranslated region of suppressor of cancer cell invasion (SCAI) in SW480 cells. Protein expression levels of matrix metalloproteinase-2/phosphoinositide 3-kinase/AKT were decreased and SCAI was increased following miR-766-5p inhibitor treatment. In conclusion, the present study indicated that miR-766-5p inhibitor repressed the process of CRC by targeting SCAI.

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Section: Discussionmentioning

confidence: 90%

The role of miR-766-5p in cell migration and invasion in colorectal cancer

2018

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“…We hope that this perspective may facilitate the understanding of multicellular dynamics with mixed phenotypes, which are frequently observed in wet-laboratory experiments and also in mathematical modeling . By modulating the composition of cellcell adhesions, collective movements are adaptive in time and space in response to soluble and structural tissue-derived signals, as well as geometric tissue properties (Haeger et al 2015;. Thus, similar to singlecell migration modes, which can switch between different types of mesenchymal and amoeboid movements, collective migration modes can interconvert and adapt to local and global signals.…”

Section: Discussionmentioning

confidence: 99%

Tuning Collective Cell Migration by Cell–Cell Junction Regulation

Friedl

Mayor

2017

Cold Spring Harb Perspect Biol

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307

253

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Collective cell migration critically depends on cell -cell interactions coupled to a dynamic actin cytoskeleton. Important cell-cell adhesion receptor systems implicated in controlling collective movements include cadherins, immunoglobulin superfamily members (L1CAM, NCAM, ALCAM), Ephrin/Eph receptors, Slit/Robo, connexins and integrins, and an adaptive array of intracellular adapter and signaling proteins. Depending on molecular composition and signaling context, cell -cell junctions adapt their shape and stability, and this gradual junction plasticity enables different types of collective cell movements such as epithelial sheet and cluster migration, branching morphogenesis and sprouting, collective network migration, as well as coordinated individual-cell migration and streaming. Thereby, plasticity of cell -cell junction composition and turnover defines the type of collective movements in epithelial, mesenchymal, neuronal, and immune cells, and defines migration coordination, anchorage, and cell dissociation. We here review cell -cell adhesion systems and their functions in different types of collective cell migration as key regulators of collective plasticity.

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“…43). Collective migration may be the rule rather than the exception in metastasis, despite the physical challenges posed by squeezing groups of cells into blood and lymphatic vessels (44).…”

Section: Discussionmentioning

confidence: 99%

Modeling and analysis of collective cell migration in an in vivo three-dimensional environment

Cai

Dai

Prasad

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

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A long-standing question in collective cell migration has been what might be the relative advantage of forming a cluster over migrating individually. Does an increase in the size of a collectively migrating group of cells enable them to sample the chemical gradient over a greater distance because the difference between front and rear of a cluster would be greater than for single cells? We combined theoretical modeling with experiments to study collective migration of the border cells in-between nurse cells in the Drosophila egg chamber. We discovered that cluster size is positively correlated with migration speed, up to a particular point above which speed plummets. This may be due to the effect of viscous drag from surrounding nurse cells together with confinement of all of the cells within a stiff extracellular matrix. The model predicts no relationship between cluster size and velocity for cells moving on a flat surface, in contrast to movement within a 3D environment. Our analyses also suggest that the overall chemoattractant profile in the egg chamber is likely to be exponential, with the highest concentration in the oocyte. These findings provide insights into collective chemotaxis by combining theoretical modeling with experimentation.cell migration | theoretical modeling | three-dimensional | chemotaxis

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Collective cell migration: guidance principles and hierarchies

Cited by 383 publications

References 142 publications

The role of miR-766-5p in cell migration and invasion in colorectal cancer

The role of miR-766-5p in cell migration and invasion in colorectal cancer

Tuning Collective Cell Migration by Cell–Cell Junction Regulation

Modeling and analysis of collective cell migration in an in vivo three-dimensional environment

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