The main goal of science/chemistry education is achieving scientific literacy for all students. For this purpose, there are some competencies and skills need to be developed in a supporting learning environment. This study aimed to examine students' perceptions on learning environment in the POGIL -SSI instruction in the chemistry solution topic. A quasi experiment with posttest only was designed. The subject consisted of 85 high school students who divided into Experiment group 1 (N = 28), Experiment group 2 (N = 29), and Contol group (N = 28) and were teached using POGIL-SSI, POGIL, and conventional instructions, respectively. Data of students' perceptions was collected using WIHIC instrument (Cronbach Apha = 0.943) and analized using One-Way ANOVA and Post-Hoc LSD test. The result shows that there is a significant difference on students' perceptions among the three groups. However, Experiment group 1 is not significantly different from Experiment gorup 2.