BackgroundCoronavirus disease 2019 is an emerging respiratory disease that is caused by a novel coronavirus and was first detected in December 2019 in Wuhan, China. The world is affected by the Corona Virus Disease in 2019. In sub-Saharan Africa Including Ethiopia there is no study conducted on level of Knowledge, Attitude and Associated Factors toward Coronavirus disease in 2019 among Health care workers Specifically Nurses.ObjectiveThis study aims to assess the level of Knowledge, Attitude and Associated Factors toward Coronavirus disease in 2019 among Nurses Who Work in South Gondar Zone, Hospitals, Northwest Ethiopia, 2020.MethodsAn Institution-based cross-sectional study was conducted among 166 Nurses in South Gondar Zone, Ethiopia, From June 1st -30/2020. To select study participants after proportional allocation of study subjects to each Hospital, simple random sampling technique were to be used. The Data was entered into Epi info version 7.2.0.1, and exported to Statistical Package for Social Sciences window version 24 for analysis. Binary and Multivariable logistic regression wasl used to see the association between dependent and independent variables. Adjusted odds ratio with 95% confidence interval was computed. P-value < 0.05 was used to declare association. Finally; the result is presented in the form of texts, tables, and graphs.ResultsOf 166 Nurses, 166 (100% response rate) responded to the online interview questionnaire. From 166 nurses, 57.2% of the participants were Females and 42.8% were males, 41.6 % of the respondents were between the ages of 20 and 29 years. About 84.9 % had good knowledge and 63.3% favorable attitude of COVID-19. Wearing general medical masks can prevent one from acquiring infection by the co vid-19 virus (AOR = 0.44, 95% CI =0.005-0.362 were factors of knowledge about COVID-19. Whereas, strongly agree Medical staffs are ready to participate in antiepidemic in the community (AOR =0.08, 95% CI = (0.003-1.76 Were factors of attitude about COVID-19.ConclusionIn this study, most of the nurses had good knowledge and favorable attitude regarding COVID-19. Wearing general medical masks can prevent one from acquiring infection by the covid-19 virus were the factors in association with knowledge OF nurses on COVID-19. Similarly, Medical staffs are ready to participate in antiepidemic in the community factors association with attitudes of nurses on COVID-19.