Collision sellar lesions: experience with eight cases and review of the literature

Koutourousiou, Maria; Kontogeorgos, George; Wesseling, Pieter; Grotenhuis, André; Seretis, Andreas

doi:10.1007/s11102-009-0190-2

Cited by 113 publications

(110 citation statements)

References 62 publications

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“…Two neighboring neoplasms must invade one another to be called "collision tumors". Extending this definition, collision lesions refer to histologically different pathological conditions found in combination and may include neoplastic, vascular, congenital, or infectious/ inflammatory lesions (75). However, according to Campbell et al, tumor-to-tumor metastasis should include certain strict criteria.…”

Section: Santral Sinir Sisteminde Tümörden Tümöre Metastazmentioning

confidence: 99%

Tumor-to-tumor metastasis of the central nervous system

Erdoğan¹,

Aydin²,

Taşdemiroğlu³

2014

Turkish Neurosurgery

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Tumor-to-tumor metastasis is a well recognized phenomenon. Although any tumor may be potential recipient of metastasis, renal cell carcinoma and meningioma are the most common malignant and benign recipients, respectively, whereas the lung and breast are the most common metastatic donors respectively, in both settings. Patients with hereditary cancer syndromes may be at higher risk for the development of tumor-to-tumor metastases. The most common pattern of tumor-to-tumor metastasis for intracranial neoplasms is the type in which an aggressive high-grade malignancy serves as the source of tumor and a more indolent neoplasm serves as the recipient tumor. The development of tumor metastasis from a second primary malignancy is uncommon and remains biologically puzzling. Its low incidence has made its full biological characterization evasive. Although rare, neurosurgeons should be aware of the entity of tumor-to-tumor metastasis. KeywoRds: Tumor, Metastasis, Central nervous system ÖZTümörden tümöre metastaz, iyi bilinen bir fenomendir. Herhangi bir tümör, metastazlar için potansiyel hedef olsa da en sık yayıldıkları malign ve benign tümörler sırasıyla renal hücreli karsinom ve menenjiyomlardır, en sık kaynaklandıkları bölgeler ise akciğer ve memedir. Herediter kanser sendromlarına sahip olan hastalar tümörden tümöre metastaz gelişimi açısından daha fazla risk taşıyabilirler. İntrakranial neoplazilerde tümörden tümöre metastazların en sık görülen şekli, saldırgan ve yüksek evreli bir tümörün daha iyi huylu bir tümöre metastazı ile olandır. Tümör metastazının ikinci bir primer malign tümörden gelişmesi az görülür ve biyolojik olarak halen şaşırtıcıdır. Bu durumun insidansının düşük olması biyolojik tanımlamanın tam olarak yapılmasını da zorlaştırmaktadır. Nadir olsa bile nöroşirürjiyenler, bir antite olarak tümörden tümöre metastaz hakkında bilgi sahibi olmalıdırlar.

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Section: Santral Sinir Sisteminde Tümörden Tümöre Metastazmentioning

confidence: 99%

Tumor-to-tumor metastasis of the central nervous system

Erdoğan¹,

Aydin²,

Taşdemiroğlu³

2014

Turkish Neurosurgery

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“…To our knowledge, approximately less than 80 cases of pituitary adenomas containing ganglions have been reported (9,11,12). The other synonyms are mixed pituitary adenomagangliocytoma, gangliocytoma with pituitary adenoma, pituitary adenoma with neuronal metaplasia (gangliocytoma), and pituitary adenoma with neuronal choristoma (PANCH).…”

Section: Discussionmentioning

confidence: 99%

“…The pathogenesis of these rare lesions is still unknown. Most combinations include the coexistence of a pituitary adenoma and a cystic tumor, particularly a Rathke cleft cyst (9,12).…”

Section: Introductionmentioning

confidence: 99%

Acromegaly associated with mixed pituitary adenoma-gangliocytoma and rathke's cleft cyst

Azarpira¹,

Pakbaz²,

Torabineghad³

et al. 2012

Turkish Neurosurgery

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Gangliocytoma of the pituitary gland is a rare lesion that often occurs in combination with pituitary adenomas and the exact origin is the subject of discussion. We report a rare case of an intrasellar mass of combined gangliocytoma/ pituitary adenoma coexistent with Rathke's cleft cyst. A 50-year-old female was admitted to our hospital with headache, mild acromegaly, and bitemporal hemianopsia. Histologically the tumor was composed of triphasic component of pituitary adenoma, clusters of ganglion cells and small cysts embedded in a variably dense neuropil substrate. Immunohistochemical analysis revealed the ganglion cells and adenoma cells were positive for synaptophysin and neurofilament. The lining of Rathke's cleft cyst was immunoreactive for cytokeratin 8. The exact pathogenesis of combined sellar pathology is not clear yet. However, a common stem/progenitor cell origin of both the adenomatous and neuronal component of these lesions has been suggested. KeywOrds: Sella, Gangliocytomas, Rathke's cleft cyst, Pituitary adenoma ÖZHipofiz bezi gangliositomu sıklıkla hipofiz adenomlarıyla kombinasyon halinde görülen nadir bir lezyondur ve kesin kökeni belli değildir. Rathke yarığı kistiyle birlikte görülen kombine gangliositom/hipofiz adenomundan oluşan nadir bir intrasellar kitle bildiriyoruz. 50 yaşında bir kadın hastanemize baş ağrısı, hafif akromegali ve bitemporal hemianopsiyle yatırıldı. Histolojik olarak tümör, hipofiz adenomunun trifazik bileşeni, gangliyon hücreleri kümeleri ve değişken şekilde yoğun nöropil substratına gömülü küçük kistlerden oluşmaktaydı. İmmünohistokimyasal analiz gangliyon hücreleri ve adenom hücrelerinin sinaptofizin ve nörofilament için pozitif olduğunu gösterdi. Rathke yarığı kistini döşeyen tabaka sitokeratin 8 için immünoreaktifti. Kombine sellar patolojinin tam patolojisi henüz kesin değildir. Ancak bu lezyonlarda hem adenomatöz hem nöronal bileşenin ortak bir kök/progenitor hücre kökeni düşünülmektedir.

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“…Between 1978 and 2014, only 115 cases of double or multiple pituitary adenomas, including clearly separated and contiguous adenomas, were reported in the literature (1)(2)(3)(4)(5)(6)(7). Furthermore, the diagnostic criteria for double or multiple pituitary adenomas vary between pathologists and clinical doctors.…”

Section: Introductionmentioning

confidence: 99%

“…The doctor making the diagnosis of double or multiple pituitary adenomas should correlate the patient's symptoms with the type of hormone produced by the tumor, since, in the majority of cases, the diagnosis of double or multiple pituitary adenomas is made only on the basis of immunohistochemical staining results. Only a few, clear cases of multiple adenomas have been confirmed by pre-and intraoperative evaluations (6,(9)(10)(11)(12). If clinicians considered the presence of ≥2 separated tumors in the same pituitary gland or the patient's clinical characteristics pre-and intraoperatively, surgical failure could be prevented to a greater extent.…”

Section: Introductionmentioning

confidence: 99%

Isolated double adrenocorticotropic hormone-secreting pituitary adenomas: A case report and review of the literature

Wang

Zhou

et al. 2016

Oncology Letters

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Abstract. Only a few cases of double or multiple pituitary adenomas have previously been reported in the literature; however, isolated double adrenocorticotropic hormone (ACTH)-secreting pituitary adenomas are even more rare. The present study reports a rare case of a 50-year-old female patient who presented with typical clinical features of Cushing's disease and was diagnosed with isolated double ACTH-secreting pituitary adenomas. Endocrinological examination revealed an ACTH-producing pituitary adenoma, and preoperative magnetic resonance imaging (MRI) demonstrated a microadenoma with a lower intensity on the right side of the pituitary gland. The patient underwent endoscopic endonasal transsphenoidal surgery, which revealed another pituitary tumor in the left side of the pituitary gland. The two, clearly separated, pituitary adenomas identified in the same gland were completely resected. Immunohistochemistry and pathology revealed that the clearly separated double pituitary adenomas were positive for ACTH, thyroid-stimulating, growth and prolactin hormones. Postoperatively, the levels of ACTH and cortisol hormone decreased rapidly. The case reported in the present study is considerably rare, due to the presence of a second pituitary adenoma in the same gland, which was not detected by preoperative MRI scan, but was noticed during surgery. Intraoperative evaluation may be important in the identification of double or multiple pituitary adenomas.

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Collision sellar lesions: experience with eight cases and review of the literature

Cited by 113 publications

References 62 publications

Tumor-to-tumor metastasis of the central nervous system

Tumor-to-tumor metastasis of the central nervous system

Acromegaly associated with mixed pituitary adenoma-gangliocytoma and rathke's cleft cyst

Isolated double adrenocorticotropic hormone-secreting pituitary adenomas: A case report and review of the literature

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