Collodion baby syndrome is a rare congenital autosomal recessive type of ichthyosis. It is a skin disorder characterised by parchment-like taut membrane which is present during birth. Collodion syndrome responds best to medical and nursing measures and may improve or resolve with the treatment of underlying condition. The nurse needs to provide emotional support to the family and impart knowledge to the care provider regarding the treatment choices and resources available. The disease process, common investigations and nursing management of collodion baby are explicated in this article. A case history is briefed with the specific nursing care provided by the community health nurse at the primary healthcare setting.