Colloidal quantum dots conjugated with human serum albumin – interactions and bioimaging properties

Non-toxic Polymeric Dots with the Strong Protein-Driven Enhancement of One- and Two-Photon Excited Emission for Sensitive and Non-destructive Albumin Sensing

“…As the carrier proteins with multiple binding centers, serum albumins play a crucial role in the versatile transport and distribution of a variety of endogenous and exogenous chemical species, such as small organic compounds, long-chain fatty acids, metal ions, and others. − Moreover, serum albumins account for the displacement of water molecules in the bloodstream, which influences the colloid osmotic pressure . The anomalies in the contents of albumins in the blood plasma (e.g., hypo- or hyperalbuminemia) can cause significant health issues, for instance, diabetes and cirrhosis, whose diagnosis is essential for the implementation of effective treatment. − The most representative blood plasma proteins, human serum albumin (HSA) and bovine serum albumin (BSA), have been therefore extensively studied in terms of biochemical and pharmaceutical assays, including bioimaging, − biosensing, , and drug delivery systems …”