Colon Targeted Delivery Systems: Review of Polysaccharides for Encapsulation and Delivery

Abstract

Colon-targeted delivery of bioactives has recently gained importance in addressing specific needs in the therapy of colon-based diseases. Many approaches have been attempted for the development of colon-specific delivery systems, with not much success in the past. Recent research into the utilization of the metabolic activity and the colonic microenvironment in the lower gastrointestinal tract has attained great value in the design of novel colon-targeted delivery systems based on natural biodegradable polymers. In the current article, special emphasis has been placed on polysaccharide systems, with minimal chemical modification, that have been exploitedfor colon targeting. These polysaccharide based encapsulation and targeted delivery systems are envisaged to have an immense potential for the development of food/nutraceutical formulations for colon-based diseases, including colorectal cancer.

Polysaccharides in Oral Drug Delivery — Recent Applications and Future Perspectives

“…In the last decades various strategies have been described for this purpose. Amongst those, various polysaccharide-based systems can be found 11,12 . One approach is the use of pHand time-dependent systems which have already been established for the treatment of colon-related diseases such as ulcerative colitis, Crohn´s disease or colorectal cancer.…”

Targeting Colon Drug Delivery by Natural Products

“…In the current articles, special emphasis has been placed on polysaccharide systems, with minimal chemical modification, that have been exploitedfor colon targeting. These polysaccharide based encapsulation and targeted delivery systems are envisaged to have an immense potential for the development of food/nutraceutical formulations for colon-based diseases, including colorectal cancer [118].Pectin-ketoprofen (PT-KP) prodrug with the potential for colon targeted delivery has been evaluated and showed KP distributes mainly in stomach, proximal small intestine and distal small intestine. However, KP released from PT-KP mainly distributes in cecum and colon.…”

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“…Single intratumoral injections of GA-AuNP resulted in X-ray contrast change of −26 HU in the tumor region after 1 h post-injection period. [126] Similarly, natural biodegradable polymers mainly polysaccharide systems are made with minimal chemical modification. These colon-targeted delivery systems contain bioactives and are used for therapy of colon-based diseases.…”