Colonic Lymphoid Nodular Hyperplasia in Children: Relationship to Food Hypersensitivity

Iacono, Giuseppe; Ravelli, A; Prima, Lidia Di; Scalici, C.; Bolognini, Stefania; Chiappa, S; Pirrone, Giuseppe; Licastri, Giuseppina; Carroccio, Antonio

doi:10.1016/j.cgh.2006.12.010

Cited by 67 publications

(63 citation statements)

References 26 publications

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“…The mucosa histology of the adults with LNH and FH strongly confirmed the data observed in children with the same clinical picture; there was an increase in the number of intraepithelial and of the lamina propria eosinophils 3,9 and in the number of lymphoid follicles. 20 The aspect of the rectal mucosa (erythema, bleeding after touching) suggests that proctitis is always present in these patients, and we suggest the rectal mucosa as the source of bleeding, with mechanisms similar to the picture of food-induced proctocolitis in infancy.…”

Section: Discussionsupporting

confidence: 78%

“…1,2 Furthermore, it can occur in school-age children, 3,5,12 who frequently exhibited LNH of the colon, which is now considered a possible marker of FH in children. [3][4][5][6][7][8] On this basis, we performed a study in adults to search for a possible relation between FH, proctitis, and LNH.…”

Section: Discussionmentioning

confidence: 99%

“…LNH was defined as a cluster of Ն10 extruding lymphoid nodules as previously described. 3 Biopsies were taken from the terminal ileum, from each segment of the colon, and from areas where endoscopic lesions were noted. Histologic examination was performed by a pathologist unaware of the clinical and laboratory data of the patients.…”

Section: Endoscopy and Histologymentioning

confidence: 99%

“…1,2 However, in a recent article we showed that rectal bleeding related to a condition of FH can occur also in school-age children. 3 In these older children the main endoscopic characteristic was the presence of lymphonodular hyperplasia (LNH) of the colon and/or the ileum. 3 Others described LNH as an endoscopic marker of cow's milk allergy in children.…”

mentioning

confidence: 99%

“…3 In these older children the main endoscopic characteristic was the presence of lymphonodular hyperplasia (LNH) of the colon and/or the ileum. 3 Others described LNH as an endoscopic marker of cow's milk allergy in children. [4][5][6][7][8] This prospective study showed that rectal bleeding and intestinal LNH can be caused by FH in adult patients.…”

mentioning

confidence: 99%

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