Colonization factor CS30 from enterotoxigenic <i>Escherichia coli</i> binds to sulfatide in human and porcine small intestine

Mentzer, Astrid von; Zalem, Dani; Chrienová, Žofia; Teneberg, Susann

doi:10.1080/21505594.2020.1749497

Cited by 9 publications

(3 citation statements)

References 41 publications

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“…Colonizing factors facilitate attachment of the organism to intestinal surfaces through adherence to specific receptors, 29,30 thereby being considered relevant virulence factors and key targets for the development of vaccine candidates. 12,16 The prevalence of specific CFs varies according to the geographic origin of the isolates, with CFA/I, CSI, CS2, CS3, CS6, CS14, and CS21 ranking among the most widely described.…”

Section: Discussionmentioning

confidence: 99%

Colonizing and Virulence Factors in Enterotoxigenic Escherichia coli from Peru

Rivera

Medina

Riveros

et al. 2023

The American Journal of Tropical Medicine and Hygiene

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Enterotoxigenic Escherichia coli (ETEC) ranks among the most relevant diarrheagenic pathogens. Efforts to design vaccines to fight ETEC have been focused on colonizing factors (CFs) and atypical virulence factors (AVF). An effective vaccine must account for differences in the regional prevalence of these CFs and AVFs to be truly effective in a given area. In the present study, the presence of 16 CFs and 9 AVFs, as well as the heat-stable (ST) variants (STh or STp), was established by polymerase chain reaction in 205 Peruvian ETEC isolates (120 from diarrhea cases and 85 from healthy controls). Ninety-nine (48.3%) isolates were heat-labile, 63 (30.7%) ST, and 43 (21.0%) presented both toxins. Of ST isolates, 59 (28.8%) possessed STh, 30 (14.6%) STp, five (2.4%) both STh and STp, and 12 (5.8%) were not amplified for any variant tested. The presence of CFs was associated with diarrhea (P < 0.0001). The presence of eatA as well as concomitant presence of CSI, CS3, and CS21 and of C5 and C6 was statistically related to diarrhea cases. The present results suggests that, if effective, a vaccine considering CS6, CS20, and CS21, together with EtpA, would provide protection against 64.4% of the isolates analyzed, whereas the addition of CS12 and EAST1 would lead to 83.9% coverage. Large studies are needed to establish both the ideal candidates to be considered to develop a vaccine effective in the area, and continuous surveillance is needed to detect displacement of circulating isolates that may compromise future vaccines.

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Section: Discussionmentioning

confidence: 99%

Colonizing and Virulence Factors in Enterotoxigenic Escherichia coli from Peru

Rivera

Medina

Riveros

et al. 2023

The American Journal of Tropical Medicine and Hygiene

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“…PLoS One 2020; 15:e0234906. Microbiome analysis in 42 patients with SIBO found a 7 3. fold lower ratio of Firmicutes to Proteobacteria than in controls.…”

mentioning

confidence: 86%

“…Produced enterotoxin is partially related to Cholera toxin. ETEC adhere via various mechanisms to the SB including colonization factors [3].…”

Section: Bacterial Infectionsmentioning

confidence: 99%

Infectious diseases affecting the small bowel – what not to miss

Keuchel

Bota²,

Baltes³

2021

Current Opinion in Gastroenterology

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Purpose of review This review summarizes infectious diseases involving the small bowel (SB) with a focus on recent literature related to diagnosis and pathophysiology. Recent findings Typical symptom for SB infections is diarrhea, mostly self-limiting. Pathogens include bacteria, viruses, fungi, protozoan parasites, and helminths. Host–pathogen interaction is of special interest in infections with potentially severe or prolonged course. Research uses increasingly enterocyte cell culture systems. SARS-CoV2 can also infect enterocytes via angiotensin converting enzyme 2 (ACE2) receptor and causes gastrointestinal complaints in some patients. Chronic SB infections as tuberculosis, Cytomegalovirus, or Epstein–Barr virus have to be differentiated from Crohn's and other diseases. Severe rare fungal and protozoan parasitic infections can cause relevant morbidity in immunocompromised patients. Soil-transmitted helminthic infections are a special issue in endemic areas. Summary Many infections involve the SB, typically causing mild and self-limiting diarrhea. Symptomatic therapy, hygiene, and isolation are the mainstay of management. However, some patients develop severe or chronic disease. Immunosuppression is a major cause for severe, but also for rare opportunistic systemic infections that can also affect the SB.

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Recent Progress on Enterotoxigenic E. coli (ETEC) and Antibiotic Resistance in Pathogenic E. coli

Joffré

Zurita

Toledo

et al. 2023

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Colonization factor CS30 from enterotoxigenic Escherichia coli binds to sulfatide in human and porcine small intestine

Cited by 9 publications

References 41 publications

Colonizing and Virulence Factors in Enterotoxigenic Escherichia coli from Peru

Colonizing and Virulence Factors in Enterotoxigenic Escherichia coli from Peru

Infectious diseases affecting the small bowel – what not to miss

Recent Progress on Enterotoxigenic E. coli (ETEC) and Antibiotic Resistance in Pathogenic E. coli

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