Color reflectance fiber bundle endomicroscopy without back-reflections

Hughes, Michael; Γιαταγάνας, Πέτρος; Yang, Guang‐Zhong

doi:10.1117/1.jbo.19.3.030501

Cited by 14 publications

(11 citation statements)

References 14 publications

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“…They show this by acquiring quasi-simultaneous endocytoscopy and fluorescence confocal endomicroscopy images through a single fiber bundle [54]. Recently, Hughes et al [55] proposed an approach that is specific to widefield endomicroscopy in which light is injected into a leached fiber bundle near the distal end, thereby avoiding reflections from the proximal face. They use this method to demonstrate color Magnification level of up to 1400-fold Quinn et al [53] Revealing changes in nuclear to cytoplasmic area ratio Hughes et al [54] White light Mahéet al [48] Tackle the problem of mosaic Reconstruction with weak a priori on the trajectory Rosa et al [60] Generate a mosaic with consideration of tissue deformation Vyas et al [61] Mosaicing by electromagnetic tracking Mountney et al [63] Using SLAM for creating a 3D roadmap of the biopsy sites Dwyer et al [64] Integration of endomicroscopy and ultrasound imaging High-resolution Imaging Yang et al [65] Learning prior information by example or parsimony…”

Section: Instrumentationmentioning

confidence: 99%

“…It can be used to interrogate clinically suspicious areas with subcellular spatial resolution, revealing changes in nuclear to cytoplasmic area ratio. A low-cost white light endomicroscopy techniques and high frame rate endomicroscopy were developed by [54][55][56]. An alternative design that instead relays images to an external camera via a coherent fiber bundle has been developed.…”

Section: Instrumentationmentioning

confidence: 99%

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Endomicroscopy for Computer and Robot Assisted Intervention

Zuo

Yang

2017

IEEE Rev. Biomed. Eng.

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Abstract-Endomicroscopy is a new technique that allows human tissue to be characterized in vivo, and in situ, circumventing the need for conventional biopsy and histology. Despite increased application and growing research interests in this area, the clinical application of endomicroscopy, however, is limited by difficulties in ergonomic control, consistent probe-tissue contact, large area surveillance and retargeting. Recently, advances in high-speed imaging, mosaicing and robotics have aimed to address these difficulties. The development of robot-assisted devices in particular has shown great promises in extending the clinical potential of endomicroscopy. Issues related to miniaturization, adaptation to tissue deformation, control stability, force and position compensation, cost and sterility are being pursued by both research and commercial communities. In this paper, recent clinical and technical developments in different aspects of computer and robotic assisted endomicroscopy interventions including instrumentation, multiscale integration, and high-speed imaging techniques are presented. We further address emerging trends and new research opportunities towards more widespread clinical acceptance of robotically assisted endomicroscopy technologies.

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Section: Instrumentationmentioning

confidence: 99%

Section: Instrumentationmentioning

confidence: 99%

Endomicroscopy for Computer and Robot Assisted Intervention

Zuo

Yang

2017

IEEE Rev. Biomed. Eng.

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“…Previously, a fiber-bundle reflectance imaging system using illumination through the imaging fiber itself without any additional illumination system has been introduced. [7][8][9]. Applying these techniques into a multipositional illumination scheme would be desirable for future study.…”

Section: Discussionmentioning

confidence: 99%

Reflectance imaging by fiber bundle endoscope: Vertical reconstruction by multipositional illumination

Ando¹,

Koida²,

Sawahata³

et al. 2016

AIP Conference Proceedings

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“…Leached fiber bundles are suitable for compatibility with clinical endoscopes because the MBR of the imaging scope is not larger than 50.8 mm [10]. To insert into the biopsy channel of commercial clinical endoscopes, we constructed our probe using a leached fiber bundle [11].…”

Section: Introductionmentioning

confidence: 99%

Clinically compatible flexible wide-field multi-color fluorescence endoscopy with a porcine colon model

Park

Yoo

et al. 2017

Biomed. Opt. Express

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Early detection of structural or molecular changes in dysplastic epithelial tissues is crucial for cancer screening and surveillance. Multi-targeting molecular endoscopic fluorescence imaging may improve noninvasive detection of precancerous lesions in the colon. Here, we report the first clinically compatible, wide-field-of-view, multi-color fluorescence endoscopy with a leached fiber bundle scope using a porcine model. A porcine colon model that resembles the human colon is used for the detection of surrogate tumors composed of multiple biocompatible fluorophores (FITC, ICG, and heavy metal-free quantum dots (hfQDs)). With an ex vivo porcine colon tumor model, molecular imaging with hfQDs conjugated with MMP14 antibody was achieved by spraying molecular probes on a mucosa layer that contains xenograft tumors. With an in vivo porcine colon embedded with surrogate tumors, target-to-background ratios of 3.36 ± 0.43, 2.70 ± 0.72, and 2.10 ± 0.13 were achieved for FITC, ICG, and hfQD probes, respectively. This promising endoscopic technology with molecular contrast shows the capacity to reveal hidden tumors and guide treatment strategy decisions. Sharma, "Comparison of the yield and miss rate of narrow band imaging and white light endoscopy in patients undergoing screening or surveillance colonoscopy: a meta-analysis," Am. J. Gastroenterol. 107(3), 363-371 (2012). 2. Sturm, M.B. and T.D. Wang," Emerging optical methods for surveillance of Barrett's oesophagus, " Gut, gutjnl-2013" Gut, gutjnl- -306706 (2015. Rat, P. Roignot, J. Faivre, P. Laurent-Puig, and F. Piard, "Mutations in the RAS-MAPK, PI (3) K (phosphatidylinositol-3-OH kinase) signaling network correlate with poor survival in a population-based series of colon cancers," Int.

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Color reflectance fiber bundle endomicroscopy without back-reflections

Cited by 14 publications

References 14 publications

Endomicroscopy for Computer and Robot Assisted Intervention

Endomicroscopy for Computer and Robot Assisted Intervention

Reflectance imaging by fiber bundle endoscope: Vertical reconstruction by multipositional illumination

Clinically compatible flexible wide-field multi-color fluorescence endoscopy with a porcine colon model

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