Colorectal cancer: does early detection matter?

Rozen, Paul

doi:10.1136/pmj.77.907.289

Cited by 6 publications

(1 citation statement)

References 9 publications

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“…Colorectal cancer is a leading cause of cancer mortality in many Western countries. This is also true for Singapore, Malaysia and certain parts of southern China, such as Hong Kong 1 . For this reason, colorectal cancer is rapidly becoming a major medical and economic burden in China.…”

Section: Introductionmentioning

confidence: 96%

A sensitive guaiac faecal occult blood test is less useful than an immunochemical test for colorectal cancer screening in a Chinese population

Wong

Cheung

et al. 2003

Aliment Pharmacol Ther

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SUMMARYBackground: Colorectal cancer screening by guaiac faecal occult blood test has been shown to reduce the incidence and mortality of colorectal cancer in Western populations. The optimal faecal occult blood test, whether guaiac or immunochemical, for colorectal cancer screening in the Chinese population remains to be defined. Aim: To compare the performance characteristics of a sensitive guaiac-based faecal occult blood test (Hemoccult SENSA) and an immunochemical faecal occult blood test (FlexSure OBT) in a Chinese population referred for colonoscopy. Methods: One hundred and thirty-five consecutive patients who were referred for colonoscopy and who met the study inclusion criteria took samples for the two faecal occult blood tests simultaneously from three successive stool specimens, with no dietary restrictions. All tests were developed and interpreted by a single experienced technician who was blind to the clinical

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Section: Introductionmentioning

confidence: 96%

A sensitive guaiac faecal occult blood test is less useful than an immunochemical test for colorectal cancer screening in a Chinese population

Wong

Cheung

et al. 2003

Aliment Pharmacol Ther

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Evaluation of an automated immunochemical fecal occult blood test for colorectal neoplasia detection in a Chinese population

Wong

Lam

Cheung

et al. 2003

Cancer

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BACKGROUNDMost commercial fecal occult blood tests (FOBT) used for colorectal carcinoma screening of Western populations are guaiac‐based, manually developed, subjective, and sensitive to dietary components. Preliminary studies demonstrated the unsuitability of these tests for screening a Chinese population. The goal of the current study was to evaluate the performance characteristics of a human hemoglobin–specific automated immunochemical FOBT, the Magstream 1000/Hem SP (Fujirebio, Inc., Tokyo, Japan), in a Chinese population referred for colonoscopy.METHODSTwo hundred fifty consecutive patients who were referred for colonoscopy and met the study inclusion criteria provided samples for the immunochemical FOBT (without dietary restrictions) from two successive stool specimens. Tests were developed with an automated instrument that had an adjustable sensitivity threshold. The sensitivity, specificity, and positive predictive value for detecting colorectal adenomas and carcinomas were calculated according to the manufacturer's instructions over a range of sensitivity levels.RESULTSAt the optimal threshold level, the sensitivity, specificity, and positive predictive value for detection of significant colorectal neoplasia (adenomas ≥ 1.0 cm and carcinomas) were 62%, 93%, and 44%, respectively. The test was easy to use, and results did not depend on operator experience.CONCLUSIONSThe automated immunochemical FOBT used in the current study was a robust, convenient, and useful tool for colorectal carcinoma screening in the study population. Cancer 2003;10:2420–4. © 2003 American Cancer Society.DOI 10.1002/cncr.11369

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Dépistage des sujets à risque moyen de cancer colorectal à Singapour par le test IFOBT

Win

Yeoh

2007

Acta Endosc

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Colorectal cancer: does early detection matter?

Cited by 6 publications

References 9 publications

A sensitive guaiac faecal occult blood test is less useful than an immunochemical test for colorectal cancer screening in a Chinese population

A sensitive guaiac faecal occult blood test is less useful than an immunochemical test for colorectal cancer screening in a Chinese population

Evaluation of an automated immunochemical fecal occult blood test for colorectal neoplasia detection in a Chinese population

Dépistage des sujets à risque moyen de cancer colorectal à Singapour par le test IFOBT

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