Colorectal cancer stem cells: a review of targeted drug delivery by gold nanoparticles

Mohd-Zahid, Manali Haniti; Mohamud, Rohimah; Abdullah, Che Azurahanim Che; Lim, JitKang; Alem, Halima; Hanaffi, Wan Nurhidayah Wan; Iskandar, Zakyyah

doi:10.1039/c9ra08192e

Cited by 47 publications

(38 citation statements)

References 120 publications

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“…Furthermore, the Anti-CD133 conjugate efficiently guides the PS to the overexpressed CD133 markers at the tumor site, where the PS is internalized via endocytosis [55]. Upon Anti-CD133 ligand-receptor docking or receptor-mediated internalization, the process is followed by fusion with lysosomes [56]. The PS can then be released by photodynamic permeabilization of the lysosomal membrane re-localizing from the lysosomes to the cytoplasm in general and more specifically the nucleus [57].…”

Section: Localization Of the Nbc In Lung Cscs-fluorescence And Differmentioning

confidence: 99%

Effective Gold Nanoparticle-Antibody-Mediated Drug Delivery for Photodynamic Therapy of Lung Cancer Stem Cells

Crous

Abrahamse

2020

IJMS

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Cancer stem cells (CSCs) are a leading contributor to lung cancer mortality rates. CSCs are responsible for tumor growth and recurrence through inhibition of drug-induced cell death, decreasing the effect of traditional cancer therapy and photodynamic therapy (PDT). PDT can be improved to successfully treat lung cancer by using gold nanoparticles (AuNPs), due to their size and shape, which have been shown to facilitate drug delivery and retention, along with the targeted antibody (Ab) mediated selection of CSCs. In this study, a nanobioconjugate (NBC) was constructed, using a photosensitizer (PS) (AlPcS4Cl), AuNPs and Abs. The NBC was characterized, using spectroscopy techniques. Photodynamic effects of the NBC on lung CSCs was evaluated, using biochemical assays 24 h post-irradiation, in order to establish its anticancer effect. Results showed successful conjugation of the nanocomposite. Localization of the NBC was seen to be in integral organelles involved in cell homeostasis. Biochemical responses of lung CSCs treated using AlPcS4Cl-AuNP and AlPcS4Cl-AuNP-Ab showed significant cell toxicity and cell death, compared to free AlPcS4Cl. The PDT effects were enhanced when using the NBC, showing significant lung CSC destruction to the point of eradication.

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Section: Localization Of the Nbc In Lung Cscs-fluorescence And Differmentioning

confidence: 99%

Effective Gold Nanoparticle-Antibody-Mediated Drug Delivery for Photodynamic Therapy of Lung Cancer Stem Cells

Crous

Abrahamse

2020

IJMS

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“…Recently, in addition to drug molecules, the attachment of peptides and polysaccharides was found to be excellent for the targeted and efficient delivery of drugs to the desired sites. [291][292][293][294] GNPs are also examined for the cellular delivery of DNA and small interfering RNA (siRNA). 209,295 In the case of nucleic acid conjugation, the electrostatic interactions between the nucleic acid and GNPs have been explored most.…”

Section: Nanoscale Advancesmentioning

confidence: 99%

Role of gold nanoparticles in advanced biomedical applications

et al. 2020

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“…Gold nanoparticles as drug delivery agents to targeted cancer cells: GNPs are the best nanocarriers for therapeutic due to their ease of synthesis, functionalization and biocompatibility [56]. In cancer therapy, GNPs are corrently used as potential drug delivery mediators for introduction into tumor cells [57]. The cells take up colloidal gold nanoparticles of different sizes and shapes [58] through ligandreceptor interaction or nonspecifi c means.…”

Section: General Applications Of Gold Naoparticlesmentioning

confidence: 99%

A Review on Gold Nanoparticles (GNPs) and their Advancement in Cancer Therapy

Shabbir¹,

Muhammad²

2021

Int J Nanomater Nanotechnol Nanomed

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nano-tubes. Different nanoparticles that are used in the treatment of targeted cancer shown in Figure 1. Innovations in nanotechnology assure to renovate synthesis of drugs, drug delivery, and clinical trials. By knowing how the materials work perversely at a particular cell or component, investigators are exposing the huge therapeutic potential of nanoscale approaches [4]. Though the plentiful study is quiet in its initial periods, researchers and investigators are producing innovative tools and evolving novel approaches for fundamental study areas for the synthesis of

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Colorectal cancer stem cells: a review of targeted drug delivery by gold nanoparticles

Abstract: The proposed schematic mechanism via which 5-fluorouracil-loaded gold nanoparticles conjugated with CD133 antibody target colorectal cancer stem cells.

Cited by 47 publications

References 120 publications

Effective Gold Nanoparticle-Antibody-Mediated Drug Delivery for Photodynamic Therapy of Lung Cancer Stem Cells

Effective Gold Nanoparticle-Antibody-Mediated Drug Delivery for Photodynamic Therapy of Lung Cancer Stem Cells

Role of gold nanoparticles in advanced biomedical applications

A Review on Gold Nanoparticles (GNPs) and their Advancement in Cancer Therapy

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