Colorimetric test-systems for creatinine detection based on composite molecularly imprinted polymer membranes

Sergeyeva, Т.А.; Gorbach, L.A.; Piletska, Elena; Piletsky, Sergey A.; Brovko, О.O.; Honcharova, L.A.; Lutsyk, А. D.; Sergeeva, L. M.; Зінченко, О. А.; El'skaya, A. V.

doi:10.1016/j.aca.2013.01.048

Cited by 57 publications

(38 citation statements)

References 31 publications

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“…In the meantime, the synthesis of MIP membranes based on the formation of colored complexes is a good method to develop colorimetric test systems. Sergeyeva et al 621 designed and synthesized new MIP membranes based on the formation of colored complexes of creatinine with picrates, capable of selective creatinine recognition. The MIP membranes were created on the surface of microfiltration polyvinylidene fluoride (PVDF) membranes using photo-initiated grafting polymerization, and then they were applied to easy-to-use colorimetric test systems for reliable detection of creatinine in analyzed samples.…”

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confidence: 99%

Molecular imprinting: perspectives and applications

et al. 2016

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a Molecular imprinting technology (MIT), often described as a method of making a molecular lock to match a molecular key, is a technique for the creation of molecularly imprinted polymers (MIPs) with tailor-made binding sites complementary to the template molecules in shape, size and functional groups. Owing to their unique features of structure predictability, recognition specificity and application universality, MIPs have found a wide range of applications in various fields. Herein, we propose to comprehensively review the recent advances in molecular imprinting including versatile perspectives and applications, concerning novel preparation technologies and strategies of MIT, and highlight the applications of MIPs. The fundamentals of MIPs involving essential elements, preparation procedures and characterization methods are briefly outlined.Smart MIT for MIPs is especially highlighted including ingenious MIT (surface imprinting, nanoimprinting, etc.), special strategies of MIT (dummy imprinting, segment imprinting, etc.) and stimuli-responsive MIT (single/dual/ multi-responsive technology). By virtue of smart MIT, new formatted MIPs gain popularity for versatile applications, including sample pretreatment/chromatographic separation (solid phase extraction, monolithic column chromatography, etc.) and chemical/biological sensing (electrochemical sensing, fluorescence sensing, etc.). Finally, we propose the remaining challenges and future perspectives to accelerate the development of MIT, and to utilize it for further developing versatile MIPs with a wide range of applications (650 references).

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Molecular imprinting: perspectives and applications

et al. 2016

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“…Thus, optimization polymerization conditions suggested that 0.3 mmol of sulpiride, 1.2 mmol of ITA, 4.5 mmol of EGDMA, 60 mg of AIBN and 6 mL of methanol for a MIP formulation, corresponding to the molar ratio of 1:4:15 for template-sulpiride/monomer-ITA/crosslinker-EGDMA, achieving a best value of specific adsorption. Recent publications frequently used the molar ratio of 1:4 although monomer could be ranging from 1 to 10 times the template in mole [25,26,27,28,29,30,31,32,33,34,35]. …”

Section: Resultsmentioning

confidence: 99%

Preparation, Characterization and Application of a Molecularly Imprinted Polymer for Selective Recognition of Sulpiride

et al. 2017

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A novel molecular imprinting polymer (MIP) was prepared by bulk polymerization using sulpiride as the template molecule, itaconic acid (ITA) as the functional monomer and ethylene glycol dimethacrylate (EGDMA) as the crosslinker. The formation of the MIP was determined as the molar ratio of sulpiride-ITA-EGDMA of 1:4:15 by single-factor experiments. The MIP showed good adsorption property with imprinting factor α of 5.36 and maximum adsorption capacity of 61.13 μmol/g, and was characterized by scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR) and surface area analysis. With the structural analogs (amisulpride, tiapride, lidocaine and cisapride) and small molecules containing a mono-functional group (p-toluenesulfonamide, formamide and 1-methylpyrrolidine) as substrates, static adsorption, kinetic adsorption, and rebinding experiments were also performed to investigate the selective adsorption ability, kinetic characteristic, and recognition mechanism of the MIP. A serial study suggested that the highly selective recognition ability of the MIP mainly depended on binding sites provided by N-functional groups of amide and amine. Moreover, the MIP as solid-phase extractant was successfully applied to extraction of sulpiride from the mixed solution (consisted of p-toluenesulfonamide, sulfamethoxazole, sulfanilamide, p-nitroaniline, acetanilide and trimethoprim) and serum sample, and extraction recoveries ranged from 81.57% to 86.63%. The tentative tests of drug release in stimulated intestinal fluid (pH 6.8) demonstrated that the tablet with the MIP–sulpiride could obviously inhibit sulpiride release rate. Thus, ITA-based MIP is an efficient and promising alternative to solid-phase adsorbent for extraction of sulpiride and removal of interferences in biosample analysis, and could be used as a potential carrier for controlled drug release.

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“…Different other substrates have been used in combination with imprinted polymers and for different purposes including dynamic (membrane and filter) and static extraction (Table S2, Table S3, and Figure S1). Among them, only MIP‐modified polyvinylidene fluoride microfiltration and commercial porous polypropylene membranes were used for “fast filtration” of 10 mL of water samples at 10 mL•min −1 . In these studies, either a thin MIP layer was created on the surface of the substrate or the substrate was immersed in a prepolymerization mixture and continued by polymerization processes.…”

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confidence: 99%

A new strategy for accelerated extraction of target compounds using molecularly imprinted polymer particles embedded in a paper‐based disk

Zarejousheghani

Schrader

Möder

et al. 2017

J of Molecular Recognition

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In this study, a general simple and inexpensive method is introduced for the preparation of a paper-based selective disk-type solid phase extraction (SPE) technique, appropriate for fast and high throughput monitoring of target compounds. An ion exchange molecularly imprinted polymer (MIP) was synthesized for the extraction and analysis of acesulfame, an anthropogenic water quality marker. Acesulfame imprinting was used as an example for demonstrating the benefits of a nanosized, swellable MIP extraction sorbents integrated in an on-site compatible concept for water quality monitoring. Compared with an 8 mL standard SPE cartridge, the paper-based MIP disk (47 mm ø) format allowed (1) high sample flow rates up to 30 mL•min without losing extraction efficiency (2) extracting sample volumes up to 500 mL in much shorter times than with standard SPE, (3) the reuse of the disks (up to 3 times more than SPE cartridge) due to high robustness and an efficient post-cleaning, and (4) reducing the sampling time from 100 minutes (using the standard SPE format) to about 2 minutes with the MIP paper disk for 50 mL water sample. Different parameters like cellulose fiber/polymer ratios, sample volume, sample flow-rate, washing, and elution conditions were evaluated and optimized. Using developed extraction technique with high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS-MS) analysis, a new protocol was established that provides detection and quantification limits of 0.015 μg•L and 0.05 μg•L , respectively. The developed paper disks were used in-field for the selective extraction of target compounds and transferred to the laboratory for further analysis.

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Colorimetric test-systems for creatinine detection based on composite molecularly imprinted polymer membranes

Cited by 57 publications

References 31 publications

Molecular imprinting: perspectives and applications

Molecular imprinting: perspectives and applications

Preparation, Characterization and Application of a Molecularly Imprinted Polymer for Selective Recognition of Sulpiride

A new strategy for accelerated extraction of target compounds using molecularly imprinted polymer particles embedded in a paper‐based disk

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